diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM9590diaendo-9590Research ArticleОригинальные исследованияOriginal StudiesИзучение влияния повышенного содержания мочевой кислоты в сыворотке крови на вероятность возникновения диабетической периферической нейропатии у пациентов с сахарным диабетом 2 типа в госпитале SoetomoCorrelation between High Serum Uric Acid Levels with Occurrence of Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus in Soetomo General HospitalSukarnoDeasy Putri

MD, Resident in Department of Neurology

dputrisukarno@gmail.comHamdanMuhammad

MD, Neurologist; Staff of Department of Neurology

mhamdan035@outlook.comFidianaFidiana

MD., Neurologist, Staff of Department of Neurology

fidiana99@yahoo.frFadilFadil

MD., Neurologist, Staff of Department of Neurology

fadil.neuro@gmail.comBasukiMudjiani

MD, Neurologist, Staff of Department of Neurology

mudjianibasuki038@outlook.com<p>Soetomo General Hospital;&nbsp;Universitas Airlangga</p>Indonesia201810102018214277282Copyright &#x00A9; Sukarno D.P., Hamdan M., Fidiana F., Fadil F., Basuki M., 20182018Sukarno D.P., Hamdan M., Fidiana F., Fadil F., Basuki M.Sukarno D.P., Hamdan M., Fidiana F., Fadil F., Basuki M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/9590Актуальность

Актуальность. Повышенное содержание мочевой кислоты (МК) в сыворотке крови при сахарном диабете 2 типа ассоциировано с высокой вероятностью макрососудистых осложнений. Однако зависимость между уровнем МК в сыворотке и риском развития диабетической периферической нейропатиии до сих пор полностью не изучена.

Цель

Цель. Целью данного исследования было изучение корреляции между повышенной концентрацией МК в сыворотке и диабетической периферической нейропатией.

Методы

Методы. В данное исследование, спланированное по типу «случай-контроль», включались последовательные пациенты в соответствии с принятыми критериями включения/исключения. Диагностику диабетической периферической нейропатии проводили с помощью электронейромиографии (ЭНМГ). Также выполняли определение уровня МК в сыворотке крови. Для оценки корреляции использовали критерий χ2 Пирсона.

Результаты

Результаты. В исследование были включены 30 пациентов, 15 из которых вошли в экспериментальную группу, а остальные 15 составили контрольную группу. Достоверной зависимости между повышенной концентрацией МК в сыворотке и диабетической периферической нейропатией выявлено не было (отношение шансов (ОШ) = 3,143; 95% доверительный интервал (ДИ) 0,681–14,503; p=0,136).

Заключение

Заключение. Нами не было установлено корреляции между высоким уровнем МК в сыворотке и диабетической периферической нейропатией.

Background

Background: The increased serum uric acid (SUA) levels have been linked to macro vascular disease in Type 2 Diabetes Melitus. The correlation between serum uric acid levels and diabetic peripheral neuropathy has not been addressed properly.

Objective

Objective: The aim of this study was to determine the correlation between high serum uric acid levels and diabetic peripheral neuropathy.

Methods

Methods: This was a case-control design study and the sampling was done consecutively by following the inclusion and the exclusion criteria. The diabetic peripheral neuropathy was evaluated using Electroneuromyography (EMNG) and the serum were taken for uric acid level examination. Chi square test was used for the correlation analysis.

Result

Result: Thirty subjects were enrolled and divided into an experimental group of 15 subjects and a control group of 15 subjects as well. We found that the diabetic peripheral neuropathy did not show a significant correlation with high serum uric acid levels, p=0,136 and OR 3,143 (CI 95% 0,681-14,503).

Conclusions

Conclusions: There was no correlation between high serum uric acid levels with diabetic peripheral neuropathy.

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The authors declare that there are no conflicts of interest present.