diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/2072-0351-815diaendo-815Research ArticleВопросы патогенезаPathogenesisГлюкагон и альфа-клетки - новая терапевтическая мишень в лечении сахарного диабетаGlucagon and alpha-cells as a novel therapeutic target in the management of diabetes mellitusПетунинаНина АлександровнаPetuninaNina Alexandrovnanapetunina@mail.ruТрухинаЛюбовь ВалентиновнаTrukhinaLyubov' Valentinovnanapetunina@mail.ruСиницынаЕлена ИгоревнаSinicynaElena Igorevnanapetunina@mail.ruШестаковаМарина ВладимировнаShestakovaMarina Vladimirovnanephro@endocrincentr.ruГБОУ ВПО Первый МГМУ им. И.М. СеченоваРоссияI.M. Sechenov First Moscow State Medical University, MoscowRussian FederationГБОУ ВПО Первый МГМУ им. И.М. Сеченова; ФГБУ Эндокринологический научный центрРоссияI.M. Sechenov First Moscow State Medical University, Moscow; Endocrinology Research Centre, MoscowRussian Federation201305112013163Сахарный диабет3540Copyright © Петунина Н.А., Трухина Л.В., Синицына Е.И., Шестакова М.В., 20132013Петунина Н.А., Трухина Л.В., Синицына Е.И., Шестакова М.В.Petunina N.A., Trukhina L.V., Sinicyna E.I., Shestakova M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/815

Десятки исследований последних лет посвящены глюкагону, его физиологическому действию в поддержании нормального уровня глюкозы и роли в патогенезе диабета. В настоящем обзоре представлены данные, раскрывающие основные этапы образования и дифференцировки эндокринных клеток поджелудочной железы. Основное внимание уделено альфа-клеткам и основным механизмам действия глюкагона. Представлены новые направления и перспективы коррекции углеводного обмена у больных сахарным диабетом, основанные на коррекции секреции глюкагона.

For the past several years, a number of studies addressed glucagon and its role in glycemic homeostasis and the development of diabetes mellitus. Current review discusses basic developmental stages of pancreatic islets with special regard for the role of beta-cells and basic mechanisms of glucagon function. We also highlight promising approaches to diabetes compensation based on adjustment of glucagon secretion.

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The authors declare that there are no conflicts of interest present.