diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM8014diaendo-8014Research ArticleДиагностика, контроль, лечениеDiagnosis, control, treatmentПерспективы использования лазерной допплеровской флоуметрии в оценке кожной микроциркуляции крови при сахарном диабетеProspects of Laser Doppler flowmetry application in assessment of skin microcirculation in diabeteshttps://orcid.org/0000-0002-4273-8295КуликовДмитрий АлександровичKulikovDmitry A.

к.м.н.

MD, PhD

zdolsk2@gmail.comhttps://orcid.org/0000-0001-6122-0638ГлазковАлексей АндреевичGlazkovAlexey A.

младший научный сотрудник

MD

staaglz@gmail.comhttps://orcid.org/0000-0001-7327-2486КовалеваЮлия АлександровнаKovalevaYulia A.

к.м.н., старший научный сотрудник отделения терапевтической эндокринологии

MD, PhD

yulia.kovaleva@mail.ruhttps://orcid.org/0000-0002-0548-3414БалашоваНаталья ВалерьевнаBalashovaNatalia V.

к.б.н., научный сотрудник биохимической лаборатории

MD, PhD in Biology

balashovan77@mail.ruhttps://orcid.org/0000-0003-1434-0615КуликовАлександр ВладимировичKulikovAlexander V.

д.б.н., заведующий лабораторией клеточно-тканевых механизмов компенсации функций биообъектов

PhD in Biology

kulikov@iteb.ru<p>ГБУЗ МО Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского</p>Россия<p>Moscow Regional Research and Clinical Institute (MONIKI)</p>Russian Federation<p>ФГБУН Институт теоретической и экспериментальной биофизики РАН</p>Россия<p>Institute of Theoretical and Experimental Biophysics of Russian Academy of Sciences</p>Russian Federation201725102017204279285Copyright &#x00A9; Куликов Д.А., Глазков А.А., Ковалева Ю.А., Балашова Н.В., Куликов А.В., 20172017Куликов Д.А., Глазков А.А., Ковалева Ю.А., Балашова Н.В., Куликов А.В.Kulikov D.A., Glazkov A.A., Kovaleva Y.A., Balashova N.V., Kulikov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/8014

В обзоре рассматриваются научные и клинические аспекты применения лазерной допплеровской флоуметрии (ЛДФ) в изучении и диагностике состояния микроциркуляторного русла при сахарном диабете (СД). ЛДФ является неинвазивным количественным методом оценки микроциркуляции, его возможности включают анализ микроциркуляторных ритмов и проведение функциональных проб с различными видами провокационных воздействий, что позволяет исследовать состояние регуляторных механизмов микроциркуляции.

Использование ЛДФ в научных исследованиях позволило выявить характерные для СД изменения функционирования микроциркуляторного русла. Результаты части работ позволяют говорить о том, что микроциркуляторные нарушения не только являются патогенетическим звеном развития осложнений, но и наблюдаются у пациентов с ранними нарушениями углеводного обмена и могут предшествовать манифестации диабета. Однако метод до сих пор не получил распространения в клинической практике. В обзоре проанализированы факторы, ограничивающие внедрение ЛДФ в практическую медицину, предложены пути повышения ее клинической значимости.

This review includes results of scientific and clinical use of laser Doppler flowmetry (LDF) in patients with diabetes mellitus. LDF is a non-invasive method for the quantitative evaluation of microcirculation, which can assess microcirculatory rhythms and conduct functional tests with various impacts, allowing the exploration of regulatory mechanisms of microcirculation.

LDF reveals specific diabetes changes in the regulatory function of microcirculation. Microcirculation disturbances, which are traditionally associated with the pathogenesis of complications, also occur in patients with early disorders of carbohydrate metabolism and may precede the manifestation of diabetes. However, this method is still not applied in clinical practice. In this review, we analysed factors limiting the implementation of LDF in practical medicine and suggest ways to improve its clinical significance.

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The authors declare that there are no conflicts of interest present.