diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM2003436-40diaendo-7758Research ArticleВопросы патогенезаPathogenesisМеханизмы транскрипционного контроля обмена глюкозы в печениMechanisms of transcriptional control of glucose metabolism in hepatocyteshttps://orcid.org/0000-0001-6954-5787КулебякинКонстантин ЮрьевичKulebyakinKonstantin Y.konstantin-kuleb@mail.ruhttps://orcid.org/0000-0002-0989-7825АкопянЖанна АлексеевнаAkopyanZhanna A.

к.м.н., доцент

MD, PhD, assistant professor

zhanna.fbm@gmail.comhttps://orcid.org/0000-0002-4869-4051КочегураТатьяна НиколаевнаKocheguraTatiana N.

к.м.н.

t_kochegur@mail.ruhttps://orcid.org/0000-0002-3741-1060ПеньковДмитрий НиколаевичPenkovDmitry N.

к.ф-м.н.

PhD

dmitry.penkov@ifom.euГБОУ ВПО Московский государственный университет имени М.В. ЛомоносоваРоссияLomonosov Moscow State UniversityRussian Federation201608072016193190198Copyright © Кулебякин К.Ю., Акопян Ж.А., Кочегура Т.Н., Пеньков Д.Н., 20162016Кулебякин К.Ю., Акопян Ж.А., Кочегура Т.Н., Пеньков Д.Н.Kulebyakin K.Y., Akopyan Z.A., Kochegura T.N., Penkov D.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/7758

Ключевую роль в регуляции и поддержании стабильного уровня глюкозы в крови играет печеночная ткань. В связи с этим именно печень как основной орган глюконеогенеза находится под постоянным гормональным контролем, определяющим метаболическую программу в гепатоцитах. Хотя гормональные сигналы и запускают множественные посттрансляционные регуляторные механизмы, изменяющие активность ключевых ферментов обмена глюкозы, важнейшую роль в долговременном контроле процессов продукции и распада глюкозы играет претрансляционная регуляция на уровне экспрессии генов метаболических ферментов. Появляется все больше данных, что именно эта регуляция, реализуемая через контроль активности транскрипционных факторов, обеспечивает постоянную подстройку организма под меняющиеся внешние условия, и именно ее нарушение приводит к развитию метаболических заболеваний, связанных с инсулиновой резистентностью. Таким образом, изучение транскрипционных факторов, регулирующих обмен глюкозы в печени, и поиски механизмов их контроля приобретают важное биомедицинское значение в контексте поиска путей лечения метаболических заболеваний.

The hepatic tissue plays a key role in the regulation and maintenance of stable blood glucose levels. The liver is the main gluconeogenesis organ of the body and is under constant hormonal control to determine the metabolic activity of hepatocytes. Hormonal signals trigger multiple post-translational regulatory mechanisms that alter the activity of key enzymes of glucose metabolism. A crucial role in the long-term control of glucose production and metabolism is played by pre-translational regulation at the level of gene expression of metabolic enzymes. There is growing evidence that this regulation, which is realised via control of the activity of transcription factors, provides constant adjustment of the body to changing environmental conditions and that its disruption leads to the development of metabolic diseases associated with insulin resistance. Therefore, the study of transcription factors that regulate glucose metabolism in the liver and the search for mechanisms to control them is of great biomedical importance in the context of metabolic disease treatment research.

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The authors declare that there are no conflicts of interest present.