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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/DM2002332-34</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-7532</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>О комбинированной терапии сахарного диабета типа 2</article-title><trans-title-group xml:lang="en"><trans-title>O kombinirovannoy terapii sakharnogo diabeta tipa 2</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мкртумян</surname><given-names>Ашот Мусаелович</given-names></name><name name-style="western" xml:lang="en"><surname>Mkrtumyan</surname><given-names>Ashot Musaelovich</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Московская медицинская академия им. И.М. Сеченова МЗ РФ</institution></aff><pub-date pub-type="collection"><year>2002</year></pub-date><pub-date pub-type="epub"><day>15</day><month>09</month><year>2002</year></pub-date><volume>5</volume><issue>3</issue><issue-title>№3 (2002)</issue-title><fpage>32</fpage><lpage>34</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мкртумян А.М., 2002</copyright-statement><copyright-year>2002</copyright-year><copyright-holder xml:lang="ru">Мкртумян А.М.</copyright-holder><copyright-holder xml:lang="en">Mkrtumyan A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/7532">https://www.dia-endojournals.ru/jour/article/view/7532</self-uri><abstract><p>Статистические данные свидетельствуют о неуклонном росте числа больных сахарным диабетом (СД), который приобрел эпидемический характер. Характер глобальной эпидемии заболеванию придает СД типа 2. которым в настоящее время болеет 150 млн. человек и, по прогнозам, в 2010 г. будет 221 млн. В РФ в 2000 г. зарегистрировано 300 тыс. больных СД типа 1 и 1 млн. 800 тыс . больных СД типа 2, а всего в РФ в 2000 г. бы-ло более 8 млн. больных СД типа 2 и к 2025 г. это число возрастет до 12 млн. Медико-социальная значимость заболеваемости СД определяется его поздними осложнениями. Сохраняется высокая летальность от кардиоваскулярных и цереброваскулярных осложнений, гангрены конечностей, ХПН. При СД типа 2 летальность от инфаркта миокарда (ИМ) в 3-4 раза, от инсульта в 2-3 раза выше, чем в популяции. Риск развития гангрены конечностей в 40 раз превышает показатели обшей популяции. Для предупреждения и/или отсрочки поздних сосудистых осложнений необходимо достижение стабильной, хорошей компенсации углеводного обмена.</p></abstract><kwd-group xml:lang="ru"><kwd>кардиоваскулярные осложнения</kwd><kwd>цереброваскулярные осложнения</kwd><kwd>целевые показатели гликемии</kwd><kwd>инсулинорезистентность</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Amos A, McCarty D, Zimmet P.//Diabetic Med. 1 997, 1 4{suppl. 5), p. 81-85</mixed-citation><mixed-citation xml:lang="en">Amos A, McCarty D, Zimmet P.//Diabetic Med. 1 997, 1 4{suppl. 5), p. 81-85</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">UKPDS//Lancet 1998, 352, P. 837-853.</mixed-citation><mixed-citation xml:lang="en">UKPDS//Lancet 1998, 352, P. 837-853.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Балаболкин М.И.//Диабетология, М., 2000, с.</mixed-citation><mixed-citation xml:lang="en">Балаболкин М.И.//Диабетология, М., 2000, с.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Haffner S.М.//Diabetes Care. 1 999, 22, 562-568.</mixed-citation><mixed-citation xml:lang="en">Haffner S.М.//Diabetes Care. 1 999, 22, 562-568.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Turner N.C., Clapham J.C.//Prog Drug Res. 1998, 51, 33-94.</mixed-citation><mixed-citation xml:lang="en">Turner N.C., Clapham J.C.//Prog Drug Res. 1998, 51, 33-94.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">De Fronzo R.A.//Neth J Med. 1997, 50, 191-197.</mixed-citation><mixed-citation xml:lang="en">De Fronzo R.A.//Neth J Med. 1997, 50, 191-197.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">De Fronzo R.A, Goodman A.M.//N Engl J Med. 1 995, 333, 541 -549.</mixed-citation><mixed-citation xml:lang="en">De Fronzo R.A, Goodman A.M.//N Engl J Med. 1 995, 333, 541 -549.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">King H, Rewers M.//Diabetes Care. 1993, 16, 157-177.</mixed-citation><mixed-citation xml:lang="en">King H, Rewers M.//Diabetes Care. 1993, 16, 157-177.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Trischitta V, Italia S, Raimondo M, Guardabasso V. et al.//J Endocrinol Invest, 1998, 21(11), 744-747.</mixed-citation><mixed-citation xml:lang="en">Trischitta V, Italia S, Raimondo M, Guardabasso V. et al.//J Endocrinol Invest, 1998, 21(11), 744-747.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Turner R, Millns H, NeilHAW et al//BMJ, 1 998, 31 6, 823828.</mixed-citation><mixed-citation xml:lang="en">Turner R, Millns H, NeilHAW et al//BMJ, 1 998, 31 6, 823828.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kenneth Си si, De Fronzo R.A.//Diabetes Reviews. 1998, 6, 89-131.</mixed-citation><mixed-citation xml:lang="en">Kenneth Си si, De Fronzo R.A.//Diabetes Reviews. 1998, 6, 89-131.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Robinson A.C, Burke T, Robinson S, Tohnston D.G.//TDiabetes Care, 1998, 21, 701-705.</mixed-citation><mixed-citation xml:lang="en">Robinson A.C, Burke T, Robinson S, Tohnston D.G.//TDiabetes Care, 1998, 21, 701-705.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Edelman S.V, Henry R.R.//Diagnosis and management of type II diabetes, 1 998, PCI, chapter 7: Oral agens.</mixed-citation><mixed-citation xml:lang="en">Edelman S.V, Henry R.R.//Diagnosis and management of type II diabetes, 1 998, PCI, chapter 7: Oral agens.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Charles M, Clark J.//Diabetes spectrum, 1 998, 1 1 (4), 21 1 -221.</mixed-citation><mixed-citation xml:lang="en">Charles M, Clark J.//Diabetes spectrum, 1 998, 1 1 (4), 21 1 -221.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
