diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM2004138-45diaendo-7111Research ArticleГенетикаGeneticsАнализ ассоциаций полиморфного маркера rs7903146 гена TCF7L2 с сахарным диабетом 2 типа в татарской этнической группе, проживающей в БашкортостанеThe association of TCF7L2 rs7903146 polymorphism with type 2 diabetes mellitus among Tatars of Bashkortostanhttps://orcid.org/0000-0002-1590-6433АвзалетдиноваДиана ШамилевнаAvzaletdinovaDiana S.

кандидат медицинских наук, доцент кафедры эндокринологии

MD, Ph.D., Senior lecturer of Endocrinology department

hyppocrat@mail.ruШариповаЛейсан ФаритовнаSharipovaLeisan F.

аспирант

MD, Postgraduate student of Endocrinology department

nauruzovaleisan@mail.ruhttps://orcid.org/0000-0002-2944-4428КочетоваОльга ВладимировнаKochetovaOlga V.

кандидат биологических наук, научный сотрудник

Ph.D. in Biology, Research associate

olga_mk78@mail.ruМоруговаТатьяна ВячеславовнаMorugovaTatyana Vyacheslavovna

доктор медицинских наук, профессор, заведующая кафедрой эндокринологии

MD, PhD, Professor, Chief of Endocrinology department

tmorugova@yandex.ruЭрдманВера ВикторовнаErdmanVera V.

кандидат биологических наук

PhD in Biology

СомоваРегина ШамилевнаSomovaRegina S.

кандидат биологических наук, научный сотрудник

PhD in Biology, Reseach associate

remuscom@mail.ruhttps://orcid.org/0000-0002-5118-6533МустафинаОльга ЕвгеньевнаMustafinaOlga E.

доктор биологических наук, заведующая лабораторией

PhD in Biology, Chief of laboratory

anmareg@mail.ruГБОУ ВПО Башкирский государственный медицинский университетРоссияBashkir State Medical University, UfaRussian FederationФГБУН Институт биохимии и генетики Уфимского научного центра РАНРоссияInstitute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of Sciences, UfaRussian Federation201607122015192119124Copyright © Авзалетдинова Д.Ш., Шарипова Л.Ф., Кочетова О.В., Моругова Т.В., Эрдман В.В., Сомова Р.Ш., Мустафина О.Е., 20162016Авзалетдинова Д.Ш., Шарипова Л.Ф., Кочетова О.В., Моругова Т.В., Эрдман В.В., Сомова Р.Ш., Мустафина О.Е.Avzaletdinova D.S., Sharipova L.F., Kochetova O.V., Morugova T.V., Erdman V.V., Somova R.S., Mustafina O.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/7111Цель

Цель. Провести анализ ассоциаций полиморфизма rs7903146 гена TCF7L2 (англ. Transcription factor 7-like 2 – транскрипционный фактор 7, подобный второму) с сахарным диабетом 2 типа (СД2) у жителей Башкортостана татарской этнической принадлежности. 

Материалы и методы

Материалы и методы. Обследованы 169 пациентов с СД2 и 286 лиц без клинических и лабораторных признаков диабета, а также без наследственной отягощенности по диабету . Амплификацию участков ДНК проводили с помощью полимеразной цепной реакции (ПЦР) в режиме реального времени с использованием TaqMan-зондов. 

Результаты

Результаты. Выявлена более высокая частота генотипа СТ и аллеля Т в группе пациентов с СД2 при сопоставлении со здоровыми лицами (46,7% против 36,4%, Р=0,030; 41,7% против 30,8%, P=0,001 соответственно). У обладателей генотипа ТТ диабет манифестировал позже (в среднем в 59,5 лет), чем у пациентов с генотипами СТ и СС (56,1 лет, Р=0,044). Уровень базального С-пептида, показатели липидного обмена, а также индекс массы тела не отличались в зависимости от генотипов rs7903146 TCF7L2. 

Заключение

Заключение. Полиморфизм rs7903146 гена TCF7L2 ассоциирован с СД2 у жителей Башкортостана татарской этнической принадлежности. Аллелем риска является аллель T (OR=1,61), протективным – аллель С (OR=0,62), Р=0,001. 

Aim

Aim. To perform the analysis of the association of transcription factor 7-like 2 (TCF7L2) gene rs7903146 polymorphism with type 2 diabetes mellitus (T2DM) among Tatars of Bashkortostan. 

Materials and methods

Materials and methods. In this study, 169 patients with T2DM and 286 controls without clinical symptoms and laboratory signs of diabetes and without diabetes relatives were examined. Amplification of the DNA fragments was performed using real-time polymerase chain reaction (PCR) and TaqMan technique. 

Results

Results. Genotype CT and allele T ratios were higher in the T2DM group than in controls (46. 7% vs. 36. 4%, p = 0. 030; 41. 7% vs. 30. 8%, p = 0. 001 respectively). There was a positive association between allele T and T2DM (OR = 1. 61), and allele C had a protective effect (OR = 0. 62, p = 0,001). Carriers of the ТТ genotype had later onset of T2DM (mean = 59. 5 years old) compared with carriers of the CT and CC genotypes (56. 1 years old, p = 0. 044). Basal C-peptide concentration, lipid levels and body mass index were not associated with TCF7L2 rs7903146 polymorphism. 

Conclusion

Conclusion. TCF7L2 rs7903146 polymorphism is associated with T2DM among Tatars of Bashkortostan. 

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The authors declare that there are no conflicts of interest present.