diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM2015346-50diaendo-6856Research ArticleГенетикаGeneticsПолиморфизм гена UBE2E2 и риск развития сахарного диабета 2 типаPolymorphism of gene UBE2E2 and the risk of developing diabetes type 2КазаковаЕлена ВладимировнаKazakovaElena Vladimirovna

M.D., степень магистра, сотрудник отделения эндокринологии, ассистент профессора, второй госпиталь Хабринского университета, пров. Хэйлунцзян.

M.D.,employee of the Department of endocrinology, assistant Professor

ELEN-84@list.ruWuYanhuiWuYanhui

M.D., степень магистра, сотрудник отделения эндокринологии, Вторая больница при Харбинском медицинском университете

M.D.,employee of the Department of endocrinology

Yanhui.wu@mail.ruChenMeijunChenMeijun

M.D., степень магистра. сотрудник отделения эндокринологии, Вторая больница при Харбинском медицинском университете

M.D., employee of the Department of endocrinology

Meijun.Chen@mail.ruWangTongtongWangTongtong

M.D., степень магистра, сотрудник отделения эндокринологии, Вторая больница при Харбинском медицинском университете

M.D., employee of the Department of endocrinology

726191320@qq.comSunLuluSunLulu

M.D.  - степень магистра. сотрудник отделения эндокринологии

M.D., employee of the Department of endocrinology

726191320@qq.comQiaoHongQiaoHong

M.D., Ph.D.

qiaoh0823@sina.comХарбинский медицинский университетКитайthe Second Affiliated Hospital, Harbin Medical University, Harbin, HeilongjiangChina2015170720151834650Copyright © Казакова Е.В., Wu Y., Chen M., Wang T., Sun L., Qiao H., 20152015Казакова Е.В., Wu Y., Chen M., Wang T., Sun L., Qiao H.Kazakova E.V., Wu Y., Chen M., Wang T., Sun L., Qiao H.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/6856

В последние годы убиквитин-протеасомный путь стал рассматриваться в качестве ключевого механизма белкового обмена. Ученые установили, что данный механизм играет важную роль в синтезе инсулина, имеет огромное значение для β-клеток поджелудочной железы и связан с возникновением инсулино-зависимых заболеваний, наиболее значимым из которых является сахарный диабет 2 типа (СД2), а также такими метаболическими заболеваниями, как ожирение и атеросклероз. Ген UBE2E2 кодирует убиквитин-связанный белок E2E2, который играет важную роль в синтезе и секреции инсулина. Ген UBE2E2 экспрессируется в поджелудочной железе, печени, жировой ткани и в инсулин-секретирующих клетках. Согласно ряду исследований, однонуклеотидные полиморфизмы гена UBE2E2 (rs6780569, rs7612463, rs9812056) связаны с повышенным риском развития СД2 у жителей Японии, Кореи и Китая. Интерес ученых к гену UBE2E2 обусловлен недавними результатами исследований, свидетельствующими о его взаимосвязи с различными заболеваниями.

Recently, the ubiquitin–proteasome pathway has emerged as a crucial pathway for protein turnover, and it has also been identified as an important factor for insulin synthesis. This pathway plays a critical role inside β cells; therefore, it has naturally been linked with various insulin-related diseases, most notably type 2 diabetes mellitus (T2DM), but also other metabolic diseases and symptoms such as obesity and atherosclerotic plaques. The UBE2E2 gene encodes ubiquitin-conjugating enzyme E2 E2 (UBE2E2), which plays an important role in the synthesis and secretion of insulin. UBE2E2  is a protein expressed in the pancreas, liver, and adipose tissue, as well as in an insulin-secreting cell line . The results of some studies have indicated that single nucleotide polymorphisms on UBE2E2 (rs6780569, rs7612463, rs9812056) are associated with T2DM risk in Japanese, Korean and Chinese populations. Therefore, the UBE2E2 gene has started to draw interest from researchers because of its newly discovered relationships with various diseases.

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The authors declare that there are no conflicts of interest present.