diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM20151101-109diaendo-6835Research ArticleДискуссияDiscussionДесять новых мишеней для разработки лекарственных средств для лечения СД2 и метаболического синдромаDrug discovery for type 2 diabetes mellitus and metabolic syndrome: ten novel biological targetsТюренковИван НиколаевичTyurenkovIvan Nikolaevich

MD, PhD, Professor, correspondence member of Russian Academy of Sciences

fibfuv@mail.ruКуркинДенис ВладимировичKurkinDenis Vladimirovich

PhD, teaching assistant

strannik986@mail.ruВолотоваЕлена ВладимировнаVolotovaElena Vladimirovna

MD, PhD, teaching assistant

a-zlato@mail.ruБакулинДмитрий АлександровичBakulinDmitriy Alexandrovich

MD, teaching assistant

mbfdoc@gmail.comЛомкинаЕлена МихайловнаLomkinaElena Michailovna

MD, teaching assistant

elenalomkina@gmail.comГБОУ ВПО "Волгоградский государственный медицинский университет", ВолгоградРоссияVolgograd State Medical University, VolgogradRussian Federation201518032015181101109Copyright © Тюренков И.Н., Куркин Д.В., Волотова Е.В., Бакулин Д.А., Ломкина Е.М., 20152015Тюренков И.Н., Куркин Д.В., Волотова Е.В., Бакулин Д.А., Ломкина Е.М.Tyurenkov I.N., Kurkin D.V., Volotova E.V., Bakulin D.A., Lomkina E.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/6835

В обзоре представлена характеристика десяти мишеней, перспективных для поиска и создания новых лекарственных средств, терапии сахарного диабета 2 типа (СД2), ожирения и метаболического синдрома. Приведены экспериментальные и клинические данные о разработке соединений, проявляющих активность в отношении SGLT2, 11b-HSD1, PTP1B, SCD1, ИЛ-1?. , фруктозо-1,6-бисфосфатазы, гликогенфосфорилазы, SIRT1, DGAT-1 и GPR119. Представленные данные свидетельствуют о перспективности фармакологического воздействия на перечисленные мишени с целью создания противодиабетических средств.

In this review we discuss ten promising biological targets of interest for treating type 2 diabetes mellitus, obesity and metabolic syndrome. Namely, we address current experimental and clinical data on several new compounds that affect SGLT2, 11b-HSD1, PTP1B, SCD1, Il-1?. , fructose-1,6-bisphosphatase, glycogen phosphorylase, SIRT1, DGAT-1 and GPR119. The body of data shows potential of these substances to become effective antidiabetic agents.

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The authors declare that there are no conflicts of interest present.