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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/DM2015170-77</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-6755</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Диагностика, контроль, лечение</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Diagnosis, control, treatment</subject></subj-group></article-categories><title-group><article-title>Соотношение дозы инсулина и массы тела как предиктор эффективности помповой инсулинотерапии у пациентов с сахарным диабетом 2 типа: пилотное исследование</article-title><trans-title-group xml:lang="en"><trans-title>Insulin/weight ratio may serve as a predictor of success during insulin pump therapy in type 2 diabetes patients: a proof-of-concept study</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0406-8021</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Левит</surname><given-names>Шмуэль</given-names></name><name name-style="western" xml:lang="en"><surname>Levit</surname><given-names>Shmuel</given-names></name></name-alternatives><bio xml:lang="ru"><p>MD, PhD,</p></bio><bio xml:lang="en"><p>MD, PhD</p></bio><email xlink:type="simple">shlevit@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филиппов</surname><given-names>Юрий Иванович</given-names></name><name name-style="western" xml:lang="en"><surname>Filippov</surname><given-names>Yury Ivanovich</given-names></name></name-alternatives><bio xml:lang="ru"><p>научный сотрудник отделения програмного обучения и лечения Института диабета ФГБУ ЭНЦ</p></bio><bio xml:lang="en"><p>MD, Assistance Researcher in Program Education and Therapy Department of the Diabetes Institute</p></bio><email xlink:type="simple">yuriyivanovich@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4337-1795</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Cohen</surname><given-names>Ohad</given-names></name><name name-style="western" xml:lang="en"><surname>Cohen</surname><given-names>Ohad</given-names></name></name-alternatives><bio xml:lang="ru"><p>профессор</p></bio><bio xml:lang="en"/><email xlink:type="simple">ohad.cohen@sheba.health.gov.il</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Weichman</surname><given-names>Мария</given-names></name><name name-style="western" xml:lang="en"><surname>Weichman</surname><given-names>Maria</given-names></name></name-alternatives><bio xml:lang="ru"><p>сотрудник Института диабета</p></bio><email xlink:type="simple">mariahdiet@gmail.com</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Azuri</surname><given-names>Joseph</given-names></name><name name-style="western" xml:lang="en"><surname>Azuri</surname><given-names>Joseph</given-names></name></name-alternatives><bio xml:lang="ru"><p>MD</p></bio><bio xml:lang="en"><p>MD</p></bio><email xlink:type="simple">azuri_yo@mac.org.il</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Manisteski</surname><given-names>Yossi</given-names></name><name name-style="western" xml:lang="en"><surname>Manisteski</surname><given-names>Yossi</given-names></name></name-alternatives><bio xml:lang="ru"><p>MD</p></bio><bio xml:lang="en"><p>MD</p></bio><email xlink:type="simple">manister_y@mac.org.il</email><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Левит</surname><given-names>Вячеслав Моисеевич</given-names></name><name name-style="western" xml:lang="en"><surname>Levit</surname><given-names>Vyacheslav Moiseevich</given-names></name></name-alternatives><bio xml:lang="ru"><p>Заведующий отделением профилактики</p></bio><bio xml:lang="en"><p>Head of the Disease prophylaxis department</p></bio><email xlink:type="simple">slava_levit@mail.ru</email><xref ref-type="aff" rid="aff-7"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт диабета, Больничная касса Маккаби, Петах-Тиква; Институт эндокринологии, диабета и метаболизма Медицинского Центра Ассута, Тель Авив</institution><country>Израиль</country></aff><aff xml:lang="en"><institution>Institute of Endocrinology and Metabolism, Sheba medical center, Tel-Aviv</institution><country>Israel</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ "Эндокринологический научный центр" Минздрава России, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Endocrinology Research Centre, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Институт эндокринологии и метаболизма, Медицинский центр Шеба, Тель-Авив</institution><country>Израиль</country></aff><aff xml:lang="en"><institution>Institute of Endocrinology, Diabetes &amp; Metabolism, Chaim Sheba Medical Center, Tel Hashomer</institution><country>Israel</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Больничная касса Маккаби, Петах-Тиква</institution><country>Израиль</country></aff><aff xml:lang="en"><institution>Institute of Diabetes, Maccabi health Fund, Petah Tiqwa</institution><country>Israel</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Отдел научных исследований, Больничная касса Маккаби, Тель-Авив</institution><country>Израиль</country></aff><aff xml:lang="en"><institution>Maccabi Health Fund, department of research, Tel Aviv</institution><country>Israel</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>Институт диабета, Больничная касса Маккаби, Петах-Тиква</institution><country>Израиль</country></aff><aff xml:lang="en"><institution>Institute of Diabetes, Maccabi health Fund, Petah Tiqwa</institution><country>Israel</country></aff></aff-alternatives><aff-alternatives id="aff-7"><aff xml:lang="ru"><institution>МБУЗ Городская Клиническая больница №8, Челябинск</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Clinical Hospital №8, Chelyabinsk</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>18</day><month>03</month><year>2015</year></pub-date><volume>18</volume><issue>1</issue><fpage>70</fpage><lpage>77</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Левит Ш., Филиппов Ю.И., Cohen O., Weichman М., Azuri J., Manisteski Y., Левит В.М., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Левит Ш., Филиппов Ю.И., Cohen O., Weichman М., Azuri J., Manisteski Y., Левит В.М.</copyright-holder><copyright-holder xml:lang="en">Levit S., Filippov Y.I., Cohen O., Weichman M., Azuri J., Manisteski Y., Levit V.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/6755">https://www.dia-endojournals.ru/jour/article/view/6755</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>инсулин</kwd><kwd>масса тела</kwd><kwd>ожирение</kwd><kwd>инсулиновая помпа</kwd><kwd>сахарный диабет 2 типа</kwd><kwd>пилотное исследование</kwd></kwd-group><kwd-group xml:lang="en"><kwd>insulin</kwd><kwd>weight</kwd><kwd>obese</kwd><kwd>pump</kwd><kwd>Type 2 diabetes</kwd><kwd>concept</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Currie CJ, Poole CD, Evans M, et al. Mortality and Other Important Diabetes-Related Outcomes With Insulin vs Other Antihyperglycemic Therapies in Type 2 Diabetes. The Journal of Clinical Endocrinology &amp; Metabolism. 2013;98(2):668–677. doi: 10.1210/jc.2012-3042.</mixed-citation><mixed-citation xml:lang="en">Currie CJ, Poole CD, Evans M, et al. Mortality and Other Important Diabetes-Related Outcomes With Insulin vs Other Antihyperglycemic Therapies in Type 2 Diabetes. The Journal of Clinical Endocrinology &amp; Metabolism. 2013;98(2):668–677. doi: 10.1210/jc.2012-3042.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Левит Ш., Филиппов Ю.И., Горелышев А.С. Сахарный диабет 2 типа: время изменить концепцию. // Сахарный диабет. – 2013. – №1 – С. 91–102. [Levit S, Phillipov YI, Gorelyshev AS. Type 2 Diabetes Mellitus: Time to change the concept. Diabetes Mellitus. 2013;16(1):91–102.] doi: 10.14341/2072-0351-3603</mixed-citation><mixed-citation xml:lang="en">Левит Ш., Филиппов Ю.И., Горелышев А.С. Сахарный диабет 2 типа: время изменить концепцию. // Сахарный диабет. – 2013. – №1 – С. 91–102. [Levit S, Phillipov YI, Gorelyshev AS. Type 2 Diabetes Mellitus: Time to change the concept. Diabetes Mellitus. 2013;16(1):91–102.] doi: 10.14341/2072-0351-3603</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Labrousse-Lhermine F, Cazals L, Ruidavets JB, Hanaire H. Long-term treatment combining continuous subcutaneous insulin infusion with oral hypoglycaemic agents is effective in type 2 diabetes. Diabetes Metab. 2007;33(4):253–260. doi: 10.1016/j.diabet.2007.01.007.</mixed-citation><mixed-citation xml:lang="en">Labrousse-Lhermine F, Cazals L, Ruidavets JB, Hanaire H. Long-term treatment combining continuous subcutaneous insulin infusion with oral hypoglycaemic agents is effective in type 2 diabetes. Diabetes Metab. 2007;33(4):253–260. doi: 10.1016/j.diabet.2007.01.007.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Herman WH, Ilag LL, Johnson SL, et al. A Clinical Trial of Continuous Subcutaneous Insulin Infusion Versus Multiple Daily Injections in Older Adults With Type 2 Diabetes. Diabetes Care. 2005;28(7):1568–1573. doi: 10.2337/diacare.28.7.1568.</mixed-citation><mixed-citation xml:lang="en">Herman WH, Ilag LL, Johnson SL, et al. A Clinical Trial of Continuous Subcutaneous Insulin Infusion Versus Multiple Daily Injections in Older Adults With Type 2 Diabetes. Diabetes Care. 2005;28(7):1568–1573. doi: 10.2337/diacare.28.7.1568.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Raskin P, Bode BW, Marks JB, et al. Continuous Subcutaneous Insulin Infusion and Multiple Daily Injection Therapy Are Equally Effective in Type 2 Diabetes: A randomized, parallel-group, 24-week study. Diabetes Care. 2003;26(9):2598–2603. doi: 10.2337/diacare.26.9.2598.</mixed-citation><mixed-citation xml:lang="en">Raskin P, Bode BW, Marks JB, et al. Continuous Subcutaneous Insulin Infusion and Multiple Daily Injection Therapy Are Equally Effective in Type 2 Diabetes: A randomized, parallel-group, 24-week study. Diabetes Care. 2003;26(9):2598–2603. doi: 10.2337/diacare.26.9.2598.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Bode BW. Insulin Pump Use in Type 2 Diabetes. Diabetes Technol. Ther. 2010;12(S1):S-17-S-21. doi: 10.1089/dia.2009.0192.</mixed-citation><mixed-citation xml:lang="en">Bode BW. Insulin Pump Use in Type 2 Diabetes. Diabetes Technol. Ther. 2010;12(S1):S-17-S-21. doi: 10.1089/dia.2009.0192.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Testa MA, Turner RR, Hayes JF, Simonson DC. Patient acceptance and satisfaction with intensive insulin therapy in type 2 diabetes: A randomized trial of the insulin pen vs. pump. Diabetes 2001; 50(Suppl 2):A428.</mixed-citation><mixed-citation xml:lang="en">Testa MA, Turner RR, Hayes JF, Simonson DC. Patient acceptance and satisfaction with intensive insulin therapy in type 2 diabetes: A randomized trial of the insulin pen vs. pump. Diabetes 2001; 50(Suppl 2):A428.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Peyrot M, Rubin RR, Chen X, Frias JP. Associations Between Improved Glucose Control and Patient-Reported Outcomes After Initiation of Insulin Pump Therapy in Patients with Type 2 Diabetes Mellitus. Diabetes Technol. Ther. 2011;13(4):471–476. doi: 10.1089/dia.2010.0167.</mixed-citation><mixed-citation xml:lang="en">Peyrot M, Rubin RR, Chen X, Frias JP. Associations Between Improved Glucose Control and Patient-Reported Outcomes After Initiation of Insulin Pump Therapy in Patients with Type 2 Diabetes Mellitus. Diabetes Technol. Ther. 2011;13(4):471–476. doi: 10.1089/dia.2010.0167.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Levit S, Toledano Y, Wainstein J. Improved glycaemic control with reduced hypoglycaemic episodes and without weight gain using long-term modern premixed insulins in type 2 diabetes. Int. J. Clin. Pract. 2011;65(2):165–171. doi: 10.1111/j.1742-1241.2010.02513.x.</mixed-citation><mixed-citation xml:lang="en">Levit S, Toledano Y, Wainstein J. Improved glycaemic control with reduced hypoglycaemic episodes and without weight gain using long-term modern premixed insulins in type 2 diabetes. Int. J. Clin. Pract. 2011;65(2):165–171. doi: 10.1111/j.1742-1241.2010.02513.x.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Pickup J. Glycaemic control with continuous subcutaneous insulin infusion compared with intensive insulin injections in patients with type 1 diabetes: meta-analysis of randomised controlled trials. BMJ. 2002;324(7339):705–705. doi: 10.1136/bmj.324.7339.705.</mixed-citation><mixed-citation xml:lang="en">Pickup J. Glycaemic control with continuous subcutaneous insulin infusion compared with intensive insulin injections in patients with type 1 diabetes: meta-analysis of randomised controlled trials. BMJ. 2002;324(7339):705–705. doi: 10.1136/bmj.324.7339.705.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Frias JP, Bode BW, Bailey TS, et al. A 16-Week Open-Label, Multicenter Pilot Study Assessing Insulin Pump Therapy in Patients with Type 2 Diabetes Suboptimally Controlled with Multiple Daily Injections. J Diabetes Sci Technol. 2011;5(4):887–893. doi: 10.1177/193229681100500410.</mixed-citation><mixed-citation xml:lang="en">Frias JP, Bode BW, Bailey TS, et al. A 16-Week Open-Label, Multicenter Pilot Study Assessing Insulin Pump Therapy in Patients with Type 2 Diabetes Suboptimally Controlled with Multiple Daily Injections. J Diabetes Sci Technol. 2011;5(4):887–893. doi: 10.1177/193229681100500410.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Lenhard MJ, Reeves GD. Continuous Subcutaneous Insulin Infusion. Arch. Intern. Med. 2001;161(19):2293. doi: 10.1001/archinte.161.19.2293.</mixed-citation><mixed-citation xml:lang="en">Lenhard MJ, Reeves GD. Continuous Subcutaneous Insulin Infusion. Arch. Intern. Med. 2001;161(19):2293. doi: 10.1001/archinte.161.19.2293.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Saudek CD, Duckworth WC, Giobbie-Hurder A, et al. Implantable Insulin Pump vs Multiple-Dose Insulin for Non—Insulin-Dependent Diabetes Mellitus. JAMA. 1996;276(16):1322. doi: 10.1001/jama.1996.03540160044031.</mixed-citation><mixed-citation xml:lang="en">Saudek CD, Duckworth WC, Giobbie-Hurder A, et al. Implantable Insulin Pump vs Multiple-Dose Insulin for Non—Insulin-Dependent Diabetes Mellitus. JAMA. 1996;276(16):1322. doi: 10.1001/jama.1996.03540160044031.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Reznik Y, Morera J, Rod A, et al. Efficacy of Continuous Subcutaneous Insulin Infusion in Type 2 Diabetes Mellitus: A Survey on a Cohort of 102 Patients with Prolonged Follow-Up. Diabetes Technol. Ther. 2010;12(12):931–936. doi: 10.1089/dia.2010.0110.</mixed-citation><mixed-citation xml:lang="en">Reznik Y, Morera J, Rod A, et al. Efficacy of Continuous Subcutaneous Insulin Infusion in Type 2 Diabetes Mellitus: A Survey on a Cohort of 102 Patients with Prolonged Follow-Up. Diabetes Technol. Ther. 2010;12(12):931–936. doi: 10.1089/dia.2010.0110.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Rubin DJ, Rybin D, Doros G, McDonnell ME. Weight-Based, Insulin Dose-Related Hypoglycemia in Hospitalized Patients With Diabetes. Diabetes Care. 2011;34(8):1723–1728. doi: 10.2337/dc10-2434.</mixed-citation><mixed-citation xml:lang="en">Rubin DJ, Rybin D, Doros G, McDonnell ME. Weight-Based, Insulin Dose-Related Hypoglycemia in Hospitalized Patients With Diabetes. Diabetes Care. 2011;34(8):1723–1728. doi: 10.2337/dc10-2434.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Leinung MC, Thompson S, Luo M, et al. Use of Insulin Pump Therapy in Patients with Type 2 Diabetes After Failure of Multiple Daily Injections. Endocr. Pract. 2013;19(1):9–13. doi: 10.4158/ep12104.or.</mixed-citation><mixed-citation xml:lang="en">Leinung MC, Thompson S, Luo M, et al. Use of Insulin Pump Therapy in Patients with Type 2 Diabetes After Failure of Multiple Daily Injections. Endocr. Pract. 2013;19(1):9–13. doi: 10.4158/ep12104.or.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Wainstein J, Metzger M, Boaz M, et al. Insulin pump therapy vs. multiple daily injections in obese Type 2 diabetic patients. Diabet. Med. 2005;22(8):1037–1046. doi: 10.1111/j.1464-5491.2005.01597.x.</mixed-citation><mixed-citation xml:lang="en">Wainstein J, Metzger M, Boaz M, et al. Insulin pump therapy vs. multiple daily injections in obese Type 2 diabetic patients. Diabet. Med. 2005;22(8):1037–1046. doi: 10.1111/j.1464-5491.2005.01597.x.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Левит Ш., Дзеранова Л.К., Филиппов Ю.И. Алгоритм лечения сахарного диабета 2 типа в свете «гравицентрической концепции». // Ожирение и метаболизм. – 2013. – №3 – С. 50–54. [Levit S, Dzeranova lK, Philippov YI. The gravicentric Concept in type 2 Diabetes: practical implementation. Obesity and metabolism. 2013;(3):50–54.] doi: 10.14341/2071-8713-3865.</mixed-citation><mixed-citation xml:lang="en">Левит Ш., Дзеранова Л.К., Филиппов Ю.И. Алгоритм лечения сахарного диабета 2 типа в свете «гравицентрической концепции». // Ожирение и метаболизм. – 2013. – №3 – С. 50–54. [Levit S, Dzeranova lK, Philippov YI. The gravicentric Concept in type 2 Diabetes: practical implementation. Obesity and metabolism. 2013;(3):50–54.] doi: 10.14341/2071-8713-3865.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
