diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM2014339-50diaendo-6735Research ArticleВопросы патогенезаPathogenesisПовреждение подоцитов при сахарном диабетеPodocyte injury in diabetes mellitusБобковаИрина НиколаевнаBobkovaIrina Nikolaevna

доктор медицинских наук, профессор кафедры нефрологии и гемодиализа института профессионального образования

MD, PhD, Professor, Department of nephrology and hemodialysis of the Institute of professional education

irbo.mma@mail.ruШестаковаМарина ВладимировнаShestakovaMarina Vladimirovna

доктор медицинских наук, профессор, член-корреспондент РАН

Директор института диабета, Заместитель директора ФГБУ Эндокринологический научный центр по научной работе

Заведующая кафедрой эндокринологии и диабетологии педиатрического факультета Первого МГМУ им. И.М. Сеченова

MD, PhD, Member of Russian Academy of Sciences

Head of the Diabetes Institute, Endocrinology Research Centre

nephro@endocrincentr.ruЩукинаАнна АлександровнаShchukinaAnna Alexandrovna

аспирант кафедры нефрологии и гемодиализа института профессионального образования

Graduate student, department of nephrology and hemodialysis of Institute of professional education

irbo.mma@mail.ruГБОУ ВПО Первый МГМУ им. И.М.СеченоваРоссияSechenov First Moscow State Medical University, MoscowRussian FederationФГБУ "Эндокринологический научный центр" Минзрава РоссииРоссияEndocrinology Research Centre, MoscowRussian Federation2014290820141733950Copyright © Бобкова И.Н., Шестакова М.В., Щукина А.А., 20142014Бобкова И.Н., Шестакова М.В., Щукина А.А.Bobkova I.N., Shestakova M.V., Shchukina A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/6735

В настоящем обзоре подробно рассмотрены механизмы повреждения подоцитов при сахарном диабете, их взаимосвязь с метаболическими и гемодинамическими нарушениями, представлены результаты последних экспериментальных и клинических исследований по данным вопросам. Авторами освещены биомаркеры, отражающие выраженность подоцитарной дисфункции и структурно-функциональных изменений в нефроне при диабетической нефропатии, обсуждены современные возможности коррекции данных нарушений с целью предупреждения прогрессирования поражения почек.

The mechanisms of podocyte injury and their correlation with metabolic and haemodynamic disorders in diabetes mellitus are considered in detail; the results of the last experimental and clinical studies on this problem are presented in this review. Authors shined the biomarkers, reflecting expressiveness of podocytopathy and structural and functional glomerular changes at diabetic nephropathy. Modern possibilities of treatment for their correction to prevent diabetic nephropathy progression are discussed.

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The authors declare that there are no conflicts of interest present.