diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM2015178-86diaendo-6714Research ArticleРепродуктивное здоровьеReproductive healthГормональные, электролитные нарушения и особенности гемостаза у доношенных новорожденных детей от матерей с гестационным сахарным диабетомHormonal, electrolyte disturbances and features of hemostasis in term newborn infants of mothers with gestational diabetes mellitus.МихалевЕвгений ВикторовичMikhalevEvgeny Viktorovich

доктор медицинских наук, профессор, заведующий кафедры педиатрии ФПК и ППС

MD, Professor, Head of the Department of Pediatrics CPP and PPP

mikhalev-ev@yandex.ruШанинаОльга МихайловнаShaninaOlga Michailovna

аспирант кафедры педиатрии ФПК и ППС

graduate student of the Department of Pediatrics CPP and PPP

shaninao@inbox.ruСапринаТатьяна ВладимировнаSaprinaTatiana Vladimirovna

кандидат медицинских наук, доцент кафедры диабетологии и эндокринологии

PhD, Associate Professor of Diabetology and Endocrinology

tanja.v.saprina@mail.ruГБОУ ВПО "Сибирский государственный медицинский университет", ТомскРоссияSiberian State Medical University, TomskRussian Federation2015190320151817886Copyright © Михалев Е.В., Шанина О.М., Саприна Т.В., 20152015Михалев Е.В., Шанина О.М., Саприна Т.В.Mikhalev E.V., Shanina O.M., Saprina T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/6714

В статье представлены имеющиеся в мировой литературе данные о результатах исследований в области электролитных (кальций, магний), гормональных (инсулин, лептин) нарушений и особенностей гемостаза у доношенных новорожденных детей от матерей с гестационным сахарным диабетом (ГСД), а также гипотез и механизмов их развития. В данном обзоре описаны изменения в содержании глюкозы в крови у доношенных новорожденных детей от матерей с ГСД и их влияние на состояние ребенка. Кроме известных факторов, ведущих к развитию макросомии и другим метаболическим нарушениям у доношенных новорожденных, рассматривается вопрос о роли лептина ? пептидного гормона, регулирующего энергетический обмен. Снижение концентрации лептина ведет к развитию ожирения. Лептин влияет на развитие мозга новорожденного, что может привести к позднему дефициту познавательной функции у детей от матерей с ГСД. Данный обзор обобщает и систематизирует имеющиеся в мировой литературе данные о результатах исследований в области электролитных и гормональных нарушений и особенностей гемостаза у доношенных детей от матерей с ГСД, а также гипотез и механизмов их развития. Обсуждаются протоколы обследования новорожденных, родившихся у матерей с ГСД, а также своевременной и патогенетически обоснованной комплексной терапии для снижения риска развития заболеваний у ребенка в будущем.

The article reviews the available data on investigations in the field of electrolyte (calcium, magnesium), hormonal (insulin, leptin) and hemostasis disturbances in term newborns from women with gestational diabetes; possible mechanisms of their development are also highlighted. The review describes changes in blood glucose concentration in term newborns from women with gestational diabetes, and their impact on the child's condition. In addition to already known factors causing macrosomia and other metabolic disorders in term neonates, the role of leptin (peptide hormone that regulates energy metabolism) is quite discussable. Low leptin levels lead to the development of obesity. It is also confirmed, that leptin influences brain development of the newborn, leading to later cognitive deficits in children from women with GDM. The aim of the review is to summarize the available data on investigations in the field of electrolyte (calcium, magnesium), hormonal (insulin, leptin) and hemostasis disturbances in term newborns from women with gestational diabetes.

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The authors declare that there are no conflicts of interest present.