diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM20143113-121diaendo-6612Research ArticleСиндром диабетической стопыDiabetic footВлияние терапии отрицательным давлением на репаративные процессы в мягких тканях нижних конечностей у пациентов с нейропатической и нейроишемической формами синдрома диабетической стопыEffect of negative pressure therapy on repair of soft tissues of the lower extremities in patients with neuropathic and neuroischaemic forms of diabetic foot syndromeЗайцеваЕкатерина ЛеонидовнаZaytsevaEkaterina Leonidovna

клинический аспирант

PhD Student

zai.kate@gmail.comДоронинаЛюдмила ПетровнаDoroninaLudmila Petrovna

кандидат медицинских наук, старший научный сотрудник отделения диабетической стопы

MD, PhD Senior Scientist

doronina.l@mail.ruМолчковРоман ВахтанговичMolchkovRoman Vakhtangovich

научный сотрудник отделения патоморфологии

Scientist, Department of Pathology, Institute of Clinical Endocrinology

romanweschapuri@rambler.ruВоронковаИя АлександровнаVoronkovaIya Alexandrovna

научный сотрудник отделения патоморфологии

Scientist, Department of Pathology, Institute of Clinical Endocrinology

iya-v@yandex.ruМитишВалерий АфанасьевичMitishValeriy Afanasievich

кандидат медицинских наук, заведующий отделением ран и раневых инфекций

MD, PhD, Head of the Wound and Wound Infections Department

doronina.l@mail.ruТокмаковаАлла ЮрьевнаTokmakovaAlla Yur'evna

доктор медицинских наук

Главный научный сотрудник отделения диабетической стопы ФГБУ ЭНЦ

Доцент кафедры эндокринологии и диабетологии педиатрического факультета Первого МГМУ им. И.М. Сеченова

MD, PhD

Lead Researcher, Diabetic Podiatry Department, Endocrinology Research Centre

Assistant professor, Endocrinology and Diabetology Department of the Pediatric Faculty, Sechenov First Moscow State Medical University

alla-tokmakova@yandex.ruФГБУ "Эндокринологический научный центр" Минздрава России, МоскваРоссияEndocrinology Research Centre, MoscowRussian FederationФГБУ Институт хирургии им.Вишневского, МоскваРоссияThe A.V. Vishnevsky Institute of surgery, MoscowRussian FederationФГБУ "Эндокринологический научный центр" Минздрава России; ГБОУ ВПО Первый МГМУ им. И.М. Сеченова, МоскваРоссияEndocrinology Research Centre, Moscow; Sechenov First Moscow State Medical University, MoscowRussian Federation201414062014173113121Copyright © Зайцева Е.Л., Доронина Л.П., Молчков Р.В., Воронкова И.А., Митиш В.А., Токмакова А.Ю., 20142014Зайцева Е.Л., Доронина Л.П., Молчков Р.В., Воронкова И.А., Митиш В.А., Токмакова А.Ю.Zaytseva E.L., Doronina L.P., Molchkov R.V., Voronkova I.A., Mitish V.A., Tokmakova A.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/6612сахарный диабетхронические раныместное лечениетерапия отрицательным давлениемрепарацияиммуногистохимические маркерыгистологияdiabetes mellituschronic woundslocal treatmentnegative pressure therapytissue repairimmunohistochemical markershistologyФГБУ "Эндокринологический научный центр" Минздрава России, МоскваEndocrinology Research Centre, MoscowReferencesSingh N, Armstrong DG, Lipsky BA. Preventing foot ulcers in patients with diabetes. JAMA 2005;293(2):217-228. doi: 10.1001/jama.293.2.217.Singh N, Armstrong DG, Lipsky BA. Preventing foot ulcers in patients with diabetes. JAMA 2005;293(2):217-228. doi: 10.1001/jama.293.2.217.Зайцева ЕЛ, Токмакова АЮ. Роль факторов роста и цитокинов в репаративных процессах в мягких тканях у больных сахарным диабетом. Сахарный диабет. 2014; (1): 57-62. [Zaytseva EL, Tokmakova AY. Effects of growth factors and cytokins on soft tissue regeneration in patients with diabetes mellitus. Diabetes mellitus 2014; (1):57-62. doi: 10.14341/DM2014157-62]Зайцева ЕЛ, Токмакова АЮ. Роль факторов роста и цитокинов в репаративных процессах в мягких тканях у больных сахарным диабетом. Сахарный диабет. 2014; (1): 57-62. [Zaytseva EL, Tokmakova AY. Effects of growth factors and cytokins on soft tissue regeneration in patients with diabetes mellitus. Diabetes mellitus 2014; (1):57-62. doi: 10.14341/DM2014157-62]Galkowska H, Wojewodzka U, Olszewski WL. Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in margin of chronic diabetic foot ulcers. Wound repair and Regen. 2006. 14(5):558-565. doi: 10.1111/j.1743-6109.2006.00155.xGalkowska H, Wojewodzka U, Olszewski WL. Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in margin of chronic diabetic foot ulcers. Wound repair and Regen. 2006. 14(5):558-565. doi: 10.1111/j.1743-6109.2006.00155.xFalanga V. Wound healing and its impairment in the diabetic foot. Lancet 2005;366(9498):1736-1743. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0140673605677008 PubMed PMID: 16291068. doi: 10.1016/S0140-6736(05)67700-8.Falanga V. Wound healing and its impairment in the diabetic foot. Lancet 2005;366(9498):1736-1743. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0140673605677008 PubMed PMID: 16291068. doi: 10.1016/S0140-6736(05)67700-8.Maruyama K, Asai J, Ii M, Thorne T, Losordo DW, D'Amore PA. Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. Am J Pathol. 2007;170(4):1178-1191.doi: 10.2353/ajpath.2007.060018Maruyama K, Asai J, Ii M, Thorne T, Losordo DW, D'Amore PA. Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. Am J Pathol. 2007;170(4):1178-1191.doi: 10.2353/ajpath.2007.060018Gibran NS, Jang YC, Isik FF, Greenhalgh DG, Muffley LA, Underwood RA, et al. Diminished neuropeptide levels contribute to the impaired cutaneous healing response associated with diabetes mellitus.J Surg Res. 2002;108(1):122-128. doi:10.1006/jsre.2002.652Gibran NS, Jang YC, Isik FF, Greenhalgh DG, Muffley LA, Underwood RA, et al. Diminished neuropeptide levels contribute to the impaired cutaneous healing response associated with diabetes mellitus.J Surg Res. 2002;108(1):122-128. doi:10.1006/jsre.2002.652Boulton A, Cavanagh P, Raymann G. New and alternative treatments for diabetic foot ulcers: hormones and growth factors. The foot in diabetes, 4th edition. John Willey& Sons, Ltd, 2006. pp. 214-221.Boulton A, Cavanagh P, Raymann G. New and alternative treatments for diabetic foot ulcers: hormones and growth factors. The foot in diabetes, 4th edition. John Willey& Sons, Ltd, 2006. pp. 214-221.Werner S, Grose R.Regulation of wound healing by growth factors and cytokines. Physiol Rev. 2003;83(3):835-870. PMid:12843410Werner S, Grose R.Regulation of wound healing by growth factors and cytokines. Physiol Rev. 2003;83(3):835-870. PMid:12843410Liu Y, Min D, Bolton T, Nubé V, Twigg SM, Yue DK, et al. Increased matrix metalloproteinase-9 predicts poor wound healing in diabetic foot ulcers.Diabetes Care. 2009;32(1):117-119. doi: 10.2337/dc08-0763Liu Y, Min D, Bolton T, Nubé V, Twigg SM, Yue DK, et al. Increased matrix metalloproteinase-9 predicts poor wound healing in diabetic foot ulcers.Diabetes Care. 2009;32(1):117-119. doi: 10.2337/dc08-0763Muller M, Trocme C, Lardy B, Morel F, Halimi S, Benhamou PY. Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing.Diabet Med. 2008;25(4):419-426. doi: 10.1111/j.1464-5491.2008.02414.x.Muller M, Trocme C, Lardy B, Morel F, Halimi S, Benhamou PY. Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing.Diabet Med. 2008;25(4):419-426. doi: 10.1111/j.1464-5491.2008.02414.x.Li Z, Guo S, Yao F, Zhang Y, Li T. Increased ratio of serum matrix metalloproteinase-9 against TIMP-1 predicts poor wound healing in diabetic foot ulcers. J Diabetes Complications. 2013;27(4):380-382. doi: 10.1016/j.jdiacomp.2012.12.007Li Z, Guo S, Yao F, Zhang Y, Li T. Increased ratio of serum matrix metalloproteinase-9 against TIMP-1 predicts poor wound healing in diabetic foot ulcers. J Diabetes Complications. 2013;27(4):380-382. doi: 10.1016/j.jdiacomp.2012.12.007Morykwas MJ, Simpson J, Punger K, Argenta A, Kremers L, Argenta J.Vacuum-assisted closure: state of basic research and physiologic foundation. Plast Reconstr Surg. 2006 Jun;117(7 Suppl):121S-126S. doi: 10.1097/01.prs.0000225450.12593.12 PMid:16799379Morykwas MJ, Simpson J, Punger K, Argenta A, Kremers L, Argenta J.Vacuum-assisted closure: state of basic research and physiologic foundation. Plast Reconstr Surg. 2006 Jun;117(7 Suppl):121S-126S. doi: 10.1097/01.prs.0000225450.12593.12 PMid:16799379Bassetto F, Lancerotto L, Salmaso R, Pandis L, Pajardi G, Schiavon M,et al. Histological evolution of chronic wounds under negative pressure therapy. J Plast Reconstr Aesthet Surg. 2012;65(1):91-99. doi: 10.1016/j.bjps.2011.08.016Bassetto F, Lancerotto L, Salmaso R, Pandis L, Pajardi G, Schiavon M,et al. Histological evolution of chronic wounds under negative pressure therapy. J Plast Reconstr Aesthet Surg. 2012;65(1):91-99. doi: 10.1016/j.bjps.2011.08.016Dinh T, Tecilazich F, Kafanas A, Doupis J, Gnardellis C, Leal E,et al. Mechanisms involved in the development and healing of diabetic foot ulceration. Diabetes. 2012;61(11):2937-2947. doi: 10.2337/db12-0227Dinh T, Tecilazich F, Kafanas A, Doupis J, Gnardellis C, Leal E,et al. Mechanisms involved in the development and healing of diabetic foot ulceration. Diabetes. 2012;61(11):2937-2947. doi: 10.2337/db12-0227Li Z, Guo S, Yao F, Zhang Y, Li T. Increased ratio of serum matrix metalloproteinase-9 against TIMP-1 predicts poor wound healing in diabetic foot ulcers. J Diabetes Complications. 2013;27(4):380-382. doi: 10.1016/j.jdiacomp.2012.12.007Li Z, Guo S, Yao F, Zhang Y, Li T. Increased ratio of serum matrix metalloproteinase-9 against TIMP-1 predicts poor wound healing in diabetic foot ulcers. J Diabetes Complications. 2013;27(4):380-382. doi: 10.1016/j.jdiacomp.2012.12.007Зайцева ЕЛ, Токмакова АЮ. Вакуум-терапия в лечении хронических ран. Сахарный диабет. 2012; (3): 45-49. [Zaytseva EL, Tokmakova AY. Vacuum therapy for chronic wounds. Diabetes mellitus. 2012;(3):45-49. doi: 10.14341/2072-0351-6085]Зайцева ЕЛ, Токмакова АЮ. Вакуум-терапия в лечении хронических ран. Сахарный диабет. 2012; (3): 45-49. [Zaytseva EL, Tokmakova AY. Vacuum therapy for chronic wounds. Diabetes mellitus. 2012;(3):45-49. doi: 10.14341/2072-0351-6085]

The authors declare that there are no conflicts of interest present.