diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/2072-0351-5585diaendo-6502Research ArticleСтатьиArticlesМолекулярно-генетические особенности, характер метаболизма глюкозы и функция эндотелия у больных метаболическим синдромом русской популяцииMolekulyarno-geneticheskie osobennosti, kharakter metabolizma glyukozy i funktsiya endoteliya u bol'nykh metabolicheskim sindromom russkoy populyatsiiМкртумянАшот МусаеловичMkrtumyanAshot Musaelovich-БирюковаЕлена ВалерьевнаBiryukovaElena Valer'evna-МаркинаН ВMarkinaN V-Московский государственный медико-стоматологический университет, Москва200815122008114№4 (2008)2630Copyright © Мкртумян А.М., Бирюкова Е.В., Маркина Н.В., 20082008Мкртумян А.М., Бирюкова Е.В., Маркина Н.В.Mkrtumyan A.M., Biryukova E.V., Markina N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/6502

При синдроме ИР сосудистая дисфункция развивается задолго до явных нарушений углеводного обмена, что свидетельствует о важности раннего выявления ИР как фактора риска эндотелиальной дисфункции. Под влиянием комплекса характерных для синдрома ИР гормонально- метаболических и гемодинамических нарушений функция эндотелия претерпевает сложные изменения, что в итоге приводит к преобладанию вазоконстрикции, раннему развитию атеросклеротических изменений и создает предпосылки для возникновения и быстрого прогрессирования сердечно-сосудистых заболеваний.

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The authors declare that there are no conflicts of interest present.