References

diaendo

Сахарный диабет

Diabetes mellitus

2072-03512072-0378

Endocrinology research centre

10.14341/DM2014220-28

diaendo-6425

Research Article

Вопросы патогенеза

Pathogenesis

Современные возможности применения стволовых клеток при сахарном диабете

Modern possibilities for using stem cells in diabetes mellitus

Дедов

Иван Иванович

Dedov

Ivan Ivanovich

доктор медицинских наук, профессор, академик РАН, Директор ФГБУ Эндокринологический научный центр Минздрава России, г.Москва

MD, PhD, Professor, Member of Russian Academy of Sciences, Director of Endocrinology Research Centre (Moscow)

laptevdn@ya.ru

Лисуков

Игорь Андреевич

Lisukov

Igor Andreevich

доктор медицинских наук, профессор, директор центра онкогематологии и трансплантологии ГБОУ ВПО СЗГМУ им. И.И. Мечникова

igor_lisukov@mail.ru

Лаптев

Дмитрий Никитич

Laptev

Dmitry Nikitich

Кандидат медицинских наук, старший научный сотрудник Института детской эндокринологии ФГБУ Эндокринологический научный центр Минздрава России, г.Москва

MD, PhD, Leading Researcher in Pediatric Endocrinology Institute, Endocrinology Research Centre (Moscow)

laptevdn@ya.ru

ФГБУ "Эндокринологический научный центр" Минздрава России, МоскваРоссияEndocrinology Research Centre, MoscowRussian Federation

Центр онкогематологии и трансплантологии СЗГМУ им. И.И. МечниковаРоссияCentre for Oncogematology and Transplantology, Northwestern State Medical University named after I.I. Mechnikov, St. PetersburgRussian Federation

2014

21042014

1722028

2014

Дедов И.И., Лисуков И.А., Лаптев Д.Н.

Dedov I.I., Lisukov I.A., Laptev D.N.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.dia-endojournals.ru/jour/article/view/6425

Сахарный диабет (СД) характеризуется относительным или абсолютным дефицитом инсулина. Современные методы лечения СД не позволяют добиться нормального уровня глюкозы в крови без эпизодов гипо- и гипергликемии и полностью предотвратить развитие осложнений СД. Замещение . ?-клеток (пересадка поджелудочной железы или . ?-клеток) сопровождается осложнениями, требует пожизненной иммуносупрессивной терапии, при этом далеко не всегда достигается инсулинонезависимость, а также имеется существенный дефицит доноров. Выходом из сложившейся ситуации может стать применение стволовых клеток (СК), которые лишены этих недостатков. Аллогенные трансплантации СК осложнены иммунным отторжением трансплантата, а использование эмбриональных СК ? этическими аспектами, сложностью отбора клеточных линий и риском возникновения тератом. Данный обзор посвящен возможностям использования тканевых СК для аутологичной трансплантации с целью восстановления пула . ?-клеток, а также иммунологической реконституции, и для модуляции аутоиммунного процесса при СД.

Diabetes mellitus (DM) is characterised by relative or absolute insulin deficiency. The currently available treatment methods for DM cannot provide normal blood glucose level without hypo- or hyperglycaemia episodes, thus failing to completely prevent the development of diabetic complications. Replacement of ?-cells (transplantation of the pancreas or ?-cells) is accompanied by complications and requires life-long immunosuppressive therapy that is not always followed by restoration of insulin independence; there is also a substantial deficit of donors. Stem cells do not cause such negative effects and can be used in therapy to avoid such problems. Allogeneic stem cell transplantation is complicated by immune rejection of a transplant, whereas the use of embryonic stem cells is associated with ethical concerns, complicated cell line selection, and risk of teratoma formation. The present review focuses on therapeutic pathways of autologous transplantation of tissue stem cells in order to restore the ?-cell pool, for immune reconstitution and modulation of the immune response in DM patients.

сахарный диабет?-клеткистволовые клеткипуповинная кровькроветворные клетки

diabetes mellitusbeta-cellsstem cellsumbilical cord bloodhaematopoietic cells

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The authors declare that there are no conflicts of interest present.