diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM2014129-33diaendo-6411Research ArticleВопросы патогенезаPathogenesisМаркеры аутоиммунного поражения печени у пациентов с сахарным диабетом 1 типаMarkers for hepatic autoimmune disorders in patients with type 1 diabetes mellitusДеревянкоОльга СергеевнаDerevyankoOlga Sergeevna

Graduate student

shapovalyants@yahoo.comДалантаеваНадежда СергеевнаDalantaevaNadejda Sergeevna

Graduate student

nsdalantaeva@gmail.comИвановаОльга НиколаевнаIvanovaOlga Nikolaevna

PhD in Biology, Leading Researcher, Head of the Laboratory of Genetics and Clinical Immunology

genetics1@yandex.ruГончаровНиколай ПетровичGoncharovNikolay Petrovich

MD, PhD, Professor, Head of the Hormonal analysis laboratory

goncharov@endocrincentr.ruНиконоваТатьяна ВасильевнаNikonovaTatiana Vasil'evna

MD, PhD, Leading Researcher, Programm education and therapy department

tatiana_nikonova@mail.ruСмирноваОльга МихайловнаSmirnovaOlga Mikhailovna

MD, PhD, Professor, Chief Researcher, Programm education and therapy department

dr_smr@mail.ruФГБУ «Эндокринологический научный центр» Минздрава РоссииРоссияEndocrinology Research CentreRussian Federation2014290320141712014 №12933Copyright © Деревянко О.С., Далантаева Н.С., Иванова О.Н., Гончаров Н.П., Никонова Т.В., Смирнова О.М., 20142014Деревянко О.С., Далантаева Н.С., Иванова О.Н., Гончаров Н.П., Никонова Т.В., Смирнова О.М.Derevyanko O.S., Dalantaeva N.S., Ivanova O.N., Goncharov N.P., Nikonova T.V., Smirnova O.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/6411сахарный диабет 1 типааутоиммунный гепатитаутоантителаtype 1 diabetes mellitusautoimmune hepatitisautoantibodiesReferencesTriolo TM, Armstrong TK, McFann K, Yu L, Rewers MJ, Klingensmith GJ, et al. Additional Autoimmune Disease Found in 33% of Patients at Type 1 Diabetes Onset. Diabetes Care 2011;34(5):1211-1213. Available from: http://care.diabetesjournals.org/cgi/doi/10.2337/dc10-1756 doi: 10.2337/dc10-1756.Triolo TM, Armstrong TK, McFann K, Yu L, Rewers MJ, Klingensmith GJ, et al. Additional Autoimmune Disease Found in 33% of Patients at Type 1 Diabetes Onset. Diabetes Care 2011;34(5):1211-1213. Available from: http://care.diabetesjournals.org/cgi/doi/10.2337/dc10-1756 doi: 10.2337/dc10-1756.Wägner AM, Santana A, Herńndez M, Wiebe JC, Nóvoa J, Mauricio D. Predictors of associated autoimmune diseases in families with type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium. Diabetes Metab. Res. Rev 2011;27(5):493-498. Available from: http://doi.wiley.com/10.1002/dmrr.1189 PubMed PMID: 21744463. doi: 10.1002/dmrr.1189.Wägner AM, Santana A, Herńndez M, Wiebe JC, Nóvoa J, Mauricio D. Predictors of associated autoimmune diseases in families with type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium. Diabetes Metab. Res. Rev 2011;27(5):493-498. Available from: http://doi.wiley.com/10.1002/dmrr.1189 PubMed PMID: 21744463. doi: 10.1002/dmrr.1189.Barker JM. Type 1 Diabetes-Associated Autoimmunity: Natural History, Genetic Associations, and Screening. The Journal of Clinical Endocrinology & Metabolism 2006;91(4):1210-1217. Available from: http://press.endocrine.org/doi/abs/10.1210/jc.2005-1679 PubMed PMID: 16403820. doi: 10.1210/jc.2005-1679.Barker JM. Type 1 Diabetes-Associated Autoimmunity: Natural History, Genetic Associations, and Screening. The Journal of Clinical Endocrinology & Metabolism 2006;91(4):1210-1217. Available from: http://press.endocrine.org/doi/abs/10.1210/jc.2005-1679 PubMed PMID: 16403820. doi: 10.1210/jc.2005-1679.Лейшнер У. Аутоиммунный гепатит. Под ред. Шептулин А, Ситкин С. Университет Франкфурт-на-Майне; 2008. 40 с. [Leĭshner W. Autoimmunnyĭ hepatitis. Ed. by Sheptulin A, Sitkin S. University Frankfurt Maĭne; 2008. 40 p.]Лейшнер У. Аутоиммунный гепатит. Под ред. Шептулин А, Ситкин С. Университет Франкфурт-на-Майне; 2008. 40 с. [Leĭshner W. Autoimmunnyĭ hepatitis. Ed. by Sheptulin A, Sitkin S. University Frankfurt Maĭne; 2008. 40 p.]Couto CA, Bittencourt PL, Porta G, Abrantes-Lemos CP, Carrilho FJ, Guardia BD, et al. Antismooth muscle and antiactin antibodies are indirect markers of histological and biochemical activity of autoimmune hepatitis. Hepatology 2013;59(2):592-600. Available from: http://doi.wiley.com/10.1002/hep.26666 doi: 10.1002/hep.26666.Couto CA, Bittencourt PL, Porta G, Abrantes-Lemos CP, Carrilho FJ, Guardia BD, et al. Antismooth muscle and antiactin antibodies are indirect markers of histological and biochemical activity of autoimmune hepatitis. Hepatology 2013;59(2):592-600. Available from: http://doi.wiley.com/10.1002/hep.26666 doi: 10.1002/hep.26666.Liu FPM, de Miranda DM, Fagundes ED, Ferreira AR, Simões e Silva AC . Autoimmune hepatitis in childhood: The role of genetic and immune factors. World J Gastroenterol 2013;19(28):4455-4463. Available from: http://www.wjgnet.com/1007-9327/full/v19/i28/4455.htm PubMed PMID: 23901220. doi: 10.3748/wjg.v19.i28.4455.Liu FPM, de Miranda DM, Fagundes ED, Ferreira AR, Simões e Silva AC . Autoimmune hepatitis in childhood: The role of genetic and immune factors. World J Gastroenterol 2013;19(28):4455-4463. Available from: http://www.wjgnet.com/1007-9327/full/v19/i28/4455.htm PubMed PMID: 23901220. doi: 10.3748/wjg.v19.i28.4455.Czaja A. Diagnosis and treatment of autoimmune hepatitis. Hepatology 2002;36(2):479-497. Available from: http://doi.wiley.com/10.1053/jhep.2002.34944 doi: 10.1053/jhep.2002.34944.Czaja A. Diagnosis and treatment of autoimmune hepatitis. Hepatology 2002;36(2):479-497. Available from: http://doi.wiley.com/10.1053/jhep.2002.34944 doi: 10.1053/jhep.2002.34944.Gabir MM, Hanson RL, Dabelea D, Imperatore G, Roumain J, Bennett PH, et al. The 1997 American Diabetes Association and 1999 World Health Organization criteria for hyperglycemia in the diagnosis and prediction of diabetes. Diabetes Care 2000;23(8):1108-1112. Available from: http://care.diabetesjournals.org/cgi/doi/10.2337/diacare.23.8.1108 doi: 10.2337/diacare.23.8.1108.Gabir MM, Hanson RL, Dabelea D, Imperatore G, Roumain J, Bennett PH, et al. The 1997 American Diabetes Association and 1999 World Health Organization criteria for hyperglycemia in the diagnosis and prediction of diabetes. Diabetes Care 2000;23(8):1108-1112. Available from: http://care.diabetesjournals.org/cgi/doi/10.2337/diacare.23.8.1108 doi: 10.2337/diacare.23.8.1108.Kessler WR, Cummings OW, Eckert G, Chalasani N, Lumeng L, Kwo PY. Fulminant hepatic failure as the initial presentation of acute autoimmune hepatitis. Clinical Gastroenterology and Hepatology 2004;2(7):625-631. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1542356504002460 PubMed PMID: 15224287. doi: 10.1016/S1542-3565(04)00246-0.Kessler WR, Cummings OW, Eckert G, Chalasani N, Lumeng L, Kwo PY. Fulminant hepatic failure as the initial presentation of acute autoimmune hepatitis. Clinical Gastroenterology and Hepatology 2004;2(7):625-631. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1542356504002460 PubMed PMID: 15224287. doi: 10.1016/S1542-3565(04)00246-0.Ивашкина ВТ. Болезни печени и желчевыводящих путей: Руководство для врачей. 2-е изд., испр. и доп. – Москва: Издательский Дом «М-Вести»; 2005. [Ivashkina VT. Bolezni pecheni i zhelchevyvodyashchikh putey: Rukovodstvo dlya vrachey. 2nd ed. Moscow: M-Vesti; 2005.]Ивашкина ВТ. Болезни печени и желчевыводящих путей: Руководство для врачей. 2-е изд., испр. и доп. – Москва: Издательский Дом «М-Вести»; 2005. [Ivashkina VT. Bolezni pecheni i zhelchevyvodyashchikh putey: Rukovodstvo dlya vrachey. 2nd ed. Moscow: M-Vesti; 2005.]Abdo A, Meddings J, Swain M. Liver abnormalities in celiac disease. Clin. Gastroenterol. Hepatol. 2004;2(2):107-112. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1542356503003136 PubMed PMID: 15017614. doi: 10.1016/S1542-3565(03)00313-6.Abdo A, Meddings J, Swain M. Liver abnormalities in celiac disease. Clin. Gastroenterol. Hepatol. 2004;2(2):107-112. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1542356503003136 PubMed PMID: 15017614. doi: 10.1016/S1542-3565(03)00313-6.Obermayer–Straub P, Perheentupa J, Braun S, Kayser A, Barut A, Loges S, et al. Hepatic autoantigens in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Gastroenterology 2001;121(3):668-677. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0016508501671221 PubMed PMID: 11522751. doi: 10.1053/gast.2001.27103.Obermayer–Straub P, Perheentupa J, Braun S, Kayser A, Barut A, Loges S, et al. Hepatic autoantigens in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Gastroenterology 2001;121(3):668-677. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0016508501671221 PubMed PMID: 11522751. doi: 10.1053/gast.2001.27103.Czaja AJ. Challenges in the diagnosis and management of autoimmune hepatitis. Can J Gastroenterol 2013;27(9):531-539. PubMed PMID: 24078938.Czaja AJ. Challenges in the diagnosis and management of autoimmune hepatitis. Can J Gastroenterol 2013;27(9):531-539. PubMed PMID: 24078938.

The authors declare that there are no conflicts of interest present.