<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/DM20142116-125</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-6408</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Фармакоэкономика</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Economic aspects</subject></subj-group></article-categories><title-group><article-title>Клинико-экономический анализ современной тактики лечения больных с метаболическим синдромом</article-title><trans-title-group xml:lang="en"><trans-title>Clinical and economic analysis of the modern strategies for treating metabolic syndrome</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Калашникова</surname><given-names>Марина Федоровна</given-names></name><name name-style="western" xml:lang="en"><surname>Kalashnikova</surname><given-names>Marina Fedorovna</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, доцент кафедры эндокринологии</p></bio><bio xml:lang="en"><p>MD, PhD, Assistant professor of the Endocrinology department</p></bio><email xlink:type="simple">marina_kalash@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Учамприна</surname><given-names>Вера</given-names></name><name name-style="western" xml:lang="en"><surname>Uchamprina</surname><given-names>Vera</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант кафедры эндокринологии</p></bio><bio xml:lang="en"><p>Postgraduate student of the Endocrinology Department</p></bio><email xlink:type="simple">vera2k@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Романцова</surname><given-names>Татьяна Ивановна</given-names></name><name name-style="western" xml:lang="en"><surname>Romantsova</surname><given-names>Tatiana Ivanovna</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>MD, PhD, Professor of the Endocrinology department</p></bio><email xlink:type="simple">romantsovatatiana@rumbler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Герасимов</surname><given-names>Андрей Николаевич</given-names></name><name name-style="western" xml:lang="en"><surname>Gerasimov</surname><given-names>Andrey Nikolaevich</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор физико-математических наук, профессор кафедры медицинской статистики</p></bio><bio xml:lang="en"><p>Doctor of technical Sciences, professor of medical statistics department</p></bio><email xlink:type="simple">andr-gerasim@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО Первый Московский государственный медицинский университет им. И.М. Сеченова, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>22</day><month>04</month><year>2014</year></pub-date><volume>17</volume><issue>2</issue><fpage>116</fpage><lpage>125</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Калашникова М.Ф., Учамприна В., Романцова Т.И., Герасимов А.Н., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Калашникова М.Ф., Учамприна В., Романцова Т.И., Герасимов А.Н.</copyright-holder><copyright-holder xml:lang="en">Kalashnikova M.F., Uchamprina V., Romantsova T.I., Gerasimov A.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/6408">https://www.dia-endojournals.ru/jour/article/view/6408</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>метаболический синдром</kwd><kwd>клинико-экономический анализ</kwd><kwd>абдоминальное ожирение</kwd><kwd>инсулинорезистентность</kwd><kwd>качество жизни</kwd><kwd>метформин</kwd><kwd>орлистат</kwd></kwd-group><kwd-group xml:lang="en"><kwd>metabolic syndrome</kwd><kwd>clinical and economic analysis</kwd><kwd>abdominal obesity</kwd><kwd>insulin resistance</kwd><kwd>quality of life</kwd><kwd>metformin</kwd><kwd>orlistat</kwd></kwd-group><funding-group><funding-statement xml:lang="en">Sechenov First Moscow State Medical University</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ross R. Reduction in Obesity and Related Comorbid Conditions after Diet-Induced Weight Loss or Exercise-Induced Weight Loss in Men. Ann Intern Med 2000;133(2):92. Available from: http://annals.org/article.aspx?doi=10.7326/0003-4819-133-2-200007180-00008 doi: 10.7326/0003-4819-133-2-200007180-00008.</mixed-citation><mixed-citation xml:lang="en">Ross R. Reduction in Obesity and Related Comorbid Conditions after Diet-Induced Weight Loss or Exercise-Induced Weight Loss in Men. Ann Intern Med 2000;133(2):92. Available from: http://annals.org/article.aspx?doi=10.7326/0003-4819-133-2-200007180-00008 doi: 10.7326/0003-4819-133-2-200007180-00008.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Вирт А. Ожирение и метаболический синдром. Уменьшается вес - снижаются уровни глюкозы и липидов в крови. Обзоры клинической кардиологии. 2006; (5). [Wirth A. Ozhirenie i metabolicheskiy sindrom. Umen'shaetsya ves - snizhayutsya urovni glyukozy i lipidov v krovi. Obzory klinicheskoy kardiologii. 2006; (5).] Available from: http://www.cardiosite.info/articles/Article.aspx?articleid=4345&amp;rubricid=96</mixed-citation><mixed-citation xml:lang="en">Вирт А. Ожирение и метаболический синдром. Уменьшается вес - снижаются уровни глюкозы и липидов в крови. Обзоры клинической кардиологии. 2006; (5). [Wirth A. Ozhirenie i metabolicheskiy sindrom. Umen'shaetsya ves - snizhayutsya urovni glyukozy i lipidov v krovi. Obzory klinicheskoy kardiologii. 2006; (5).] Available from: http://www.cardiosite.info/articles/Article.aspx?articleid=4345&amp;rubricid=96</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Heneghan C. Considerable uncertainty remains in the evidence for primary prevention of cardiovascular disease. 2011. Available from: http://www.thecochranelibrary.com</mixed-citation><mixed-citation xml:lang="en">Heneghan C. Considerable uncertainty remains in the evidence for primary prevention of cardiovascular disease. 2011. Available from: http://www.thecochranelibrary.com</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Davidson MH, Hauptman J, DiGirolamo M, Foreyt JP, Halsted CH, Heber D, et al. Weight Control and Risk Factor Reduction in Obese Subjects Treated for 2 Years With Orlistat. JAMA 1999;281(3):235-281. Available from: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.281.3.235 doi: 10.1001/jama.281.3.235.</mixed-citation><mixed-citation xml:lang="en">Davidson MH, Hauptman J, DiGirolamo M, Foreyt JP, Halsted CH, Heber D, et al. Weight Control and Risk Factor Reduction in Obese Subjects Treated for 2 Years With Orlistat. JAMA 1999;281(3):235-281. Available from: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.281.3.235 doi: 10.1001/jama.281.3.235.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Garber AJ, Handelsman Y, Einhorn D, Bergman DA, Bloomgarden ZT, Fonseca V, et al. Diagnosis and Management of Prediabetes in the Continuum of Hyperglycemia—When do the Risks of Diabetes Begin? A Consensus Statement from the American College of Endocrinology and the American Association of Clinical Endocrinologists. Endocrine Practice 2008;14(7):933-946. Available from: http://aace.metapress.com/openurl.asp?genre=article&amp;id=doi:10.4158/EP.14.7.933 doi: 10.4158/EP.14.7.933.</mixed-citation><mixed-citation xml:lang="en">Garber AJ, Handelsman Y, Einhorn D, Bergman DA, Bloomgarden ZT, Fonseca V, et al. Diagnosis and Management of Prediabetes in the Continuum of Hyperglycemia—When do the Risks of Diabetes Begin? A Consensus Statement from the American College of Endocrinology and the American Association of Clinical Endocrinologists. Endocrine Practice 2008;14(7):933-946. Available from: http://aace.metapress.com/openurl.asp?genre=article&amp;id=doi:10.4158/EP.14.7.933 doi: 10.4158/EP.14.7.933.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Isomaa B, Almgren P, Tuomi T, Forsen B, Lahti K, Nissen M, et al. Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome. Diabetes Care 2001;24(4):683-689. Available from: http://care.diabetesjournals.org/cgi/doi/10.2337/diacare.24.4.683 doi: 10.2337/diacare.24.4.683.</mixed-citation><mixed-citation xml:lang="en">Isomaa B, Almgren P, Tuomi T, Forsen B, Lahti K, Nissen M, et al. Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome. Diabetes Care 2001;24(4):683-689. Available from: http://care.diabetesjournals.org/cgi/doi/10.2337/diacare.24.4.683 doi: 10.2337/diacare.24.4.683.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Lorenzo C, Okoloise M, Williams K, Stern MP, Haffner SM. The Metabolic Syndrome as Predictor of Type 2 Diabetes: The San Antonio Heart Study. Diabetes Care 2003;26(11):3153-3159. Available from: http://care.diabetesjournals.org/cgi/doi/10.2337/diacare.26.11.3153 doi: 10.2337/diacare.26.11.3153.</mixed-citation><mixed-citation xml:lang="en">Lorenzo C, Okoloise M, Williams K, Stern MP, Haffner SM. The Metabolic Syndrome as Predictor of Type 2 Diabetes: The San Antonio Heart Study. Diabetes Care 2003;26(11):3153-3159. Available from: http://care.diabetesjournals.org/cgi/doi/10.2337/diacare.26.11.3153 doi: 10.2337/diacare.26.11.3153.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kothari V, Stevens RJ, Adler AI, Stratton IM, Manley SE, Neil HA, et al. UKPDS 60: Risk of Stroke in Type 2 Diabetes Estimated by the UK Prospective Diabetes Study Risk Engine. Stroke 2002 июля;33(7):1776-1781. Available from: http://stroke.ahajournals.org/cgi/doi/10.1161/01.STR.0000020091.07144.C7 doi: 10.1161/01.STR.0000020091.07144.C7.</mixed-citation><mixed-citation xml:lang="en">Kothari V, Stevens RJ, Adler AI, Stratton IM, Manley SE, Neil HA, et al. UKPDS 60: Risk of Stroke in Type 2 Diabetes Estimated by the UK Prospective Diabetes Study Risk Engine. Stroke 2002 июля;33(7):1776-1781. Available from: http://stroke.ahajournals.org/cgi/doi/10.1161/01.STR.0000020091.07144.C7 doi: 10.1161/01.STR.0000020091.07144.C7.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Гусев ЕИ, Скворцова ВИ, Стаховская ЛВ. Эпидемиология инсульта в России. Журнал неврологии и психиатрии имени С.С.Корсакова. 2003;(8):4-9. [Gusev EI, Skvortsova VI, Stakhovskaya LV. Epidemiologiya insul'ta v Rossii. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2003;(8):4-9.]</mixed-citation><mixed-citation xml:lang="en">Гусев ЕИ, Скворцова ВИ, Стаховская ЛВ. Эпидемиология инсульта в России. Журнал неврологии и психиатрии имени С.С.Корсакова. 2003;(8):4-9. [Gusev EI, Skvortsova VI, Stakhovskaya LV. Epidemiologiya insul'ta v Rossii. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2003;(8):4-9.]</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Mortality from Coronary Heart Disease in Subjects with Type 2 Diabetes and in Nondiabetic Subjects with and without Prior Myocardial Infarction. N Engl J Med 1998;339(4):229-234. Available from: http://www.nejm.org/doi/abs/10.1056/NEJM199807233390404 PubMed PMID: 9673301. doi: 10.1056/NEJM199807233390404.</mixed-citation><mixed-citation xml:lang="en">Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Mortality from Coronary Heart Disease in Subjects with Type 2 Diabetes and in Nondiabetic Subjects with and without Prior Myocardial Infarction. N Engl J Med 1998;339(4):229-234. Available from: http://www.nejm.org/doi/abs/10.1056/NEJM199807233390404 PubMed PMID: 9673301. doi: 10.1056/NEJM199807233390404.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">de Fine Olivarius N, Siersma V, Nielsen ABS, Hansen LJ, Rosenvinge L, Mogensen C. Predictors of mortality of patients newly diagnosed with clinical type 2 diabetes: a 5-year follow up study. BMC Endocr Disord 2010;10(1):14-1186. Available from: http://www.biomedcentral.com/1472-6823/10/14 doi: 10.1186/1472-6823-10-14.</mixed-citation><mixed-citation xml:lang="en">de Fine Olivarius N, Siersma V, Nielsen ABS, Hansen LJ, Rosenvinge L, Mogensen C. Predictors of mortality of patients newly diagnosed with clinical type 2 diabetes: a 5-year follow up study. BMC Endocr Disord 2010;10(1):14-1186. Available from: http://www.biomedcentral.com/1472-6823/10/14 doi: 10.1186/1472-6823-10-14.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack. The Lancet 2001;358(9287):1033-1041. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0140673601061785 doi: 10.1016/S0140-6736(01)06178-5.</mixed-citation><mixed-citation xml:lang="en">Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack. The Lancet 2001;358(9287):1033-1041. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0140673601061785 doi: 10.1016/S0140-6736(01)06178-5.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Ulvtrstam A. Ten year decline in ischemic stroke after AMI. Prevention and outcome after cardiac ischemia. Munich: ESC Press Releases; 2012. Available from: http://www.escardio.org/about/press/press-releases/esc12-munich/Pages/ten-year-decline-stroke-after-ami.aspx</mixed-citation><mixed-citation xml:lang="en">Ulvtrstam A. Ten year decline in ischemic stroke after AMI. Prevention and outcome after cardiac ischemia. Munich: ESC Press Releases; 2012. Available from: http://www.escardio.org/about/press/press-releases/esc12-munich/Pages/ten-year-decline-stroke-after-ami.aspx</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Люсов ВА, Волов НА, Гордеев ИГ. Инфаркт миокарда. М: Литтера, 2010 - 240 с. [Lyusov VA, Volov NA, Gordeev IG. Infarkt miokarda. Moscow: Littera; 2010. 240 p.]</mixed-citation><mixed-citation xml:lang="en">Люсов ВА, Волов НА, Гордеев ИГ. Инфаркт миокарда. М: Литтера, 2010 - 240 с. [Lyusov VA, Volov NA, Gordeev IG. Infarkt miokarda. Moscow: Littera; 2010. 240 p.]</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Herlitz J, Malmberg K, Karlson BW, Rydén L, Hjalmarson A. Mortality and Morbidity During a Five-year Follow-up of Diabetics with Myocardial Infarction. Acta Medica Scandinavica 2009;224(1):31-38. Available from: http://doi.wiley.com/10.1111/j.0954-6820.1988.tb16735.x doi: 10.1111/j.0954-6820.1988.tb16735.x.</mixed-citation><mixed-citation xml:lang="en">Herlitz J, Malmberg K, Karlson BW, Rydén L, Hjalmarson A. Mortality and Morbidity During a Five-year Follow-up of Diabetics with Myocardial Infarction. Acta Medica Scandinavica 2009;224(1):31-38. Available from: http://doi.wiley.com/10.1111/j.0954-6820.1988.tb16735.x doi: 10.1111/j.0954-6820.1988.tb16735.x.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Schrader J, Luders S, Kulschewski A, Hammersen F, Plate K, Berger J, et al. Morbidity and Mortality After Stroke, Eprosartan Compared With Nitrendipine for Secondary Prevention: Principal Results of a Prospective Randomized Controlled Study (MOSES). Stroke 1161;36(6):1218-1224. Available from: http://stroke.ahajournals.org/cgi/doi/10.1161/01.STR.0000166048.35740.a9 doi: 10.1161/01.STR.0000166048.35740.a9.</mixed-citation><mixed-citation xml:lang="en">Schrader J, Luders S, Kulschewski A, Hammersen F, Plate K, Berger J, et al. Morbidity and Mortality After Stroke, Eprosartan Compared With Nitrendipine for Secondary Prevention: Principal Results of a Prospective Randomized Controlled Study (MOSES). Stroke 1161;36(6):1218-1224. Available from: http://stroke.ahajournals.org/cgi/doi/10.1161/01.STR.0000166048.35740.a9 doi: 10.1161/01.STR.0000166048.35740.a9.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Яхно НН, Штульман ДР. Болезни нервной системы. Руководство для врачей. М: Медицина; 2004.[Yakhno NN, Shtul'man DR. Bolezni nervnoy sistemy. Rukovodstvo dlya vrachey. Moscow: Meditsina; 2004.]</mixed-citation><mixed-citation xml:lang="en">Яхно НН, Штульман ДР. Болезни нервной системы. Руководство для врачей. М: Медицина; 2004.[Yakhno NN, Shtul'man DR. Bolezni nervnoy sistemy. Rukovodstvo dlya vrachey. Moscow: Meditsina; 2004.]</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin. N Engl J Med 2002;346(6):393-403. Available from: http://www.nejm.org/doi/abs/10.1056/NEJMoa012512 doi: 10.1056/NEJMoa012512.</mixed-citation><mixed-citation xml:lang="en">Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin. N Engl J Med 2002;346(6):393-403. Available from: http://www.nejm.org/doi/abs/10.1056/NEJMoa012512 doi: 10.1056/NEJMoa012512.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Williamson DF, Pamuk E, Thun M, Flanders D, Byers T, Heath C. Prospective study of international weight loss and mortality in never smoking overweight US white women aged 40-64 years. Am J Epidemiol. 1995;141:1128-1141.</mixed-citation><mixed-citation xml:lang="en">Williamson DF, Pamuk E, Thun M, Flanders D, Byers T, Heath C. Prospective study of international weight loss and mortality in never smoking overweight US white women aged 40-64 years. Am J Epidemiol. 1995;141:1128-1141.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Бутрова СА. Сибутрамин (Меридиа) в лечении ожирения: опыт применения в России. Клиническая фармакология и терапия. 2001;10(2):55-58.[Butrova SA. Sibutramin (Meridia) v lechenii ozhireniya: opyt primeneniya v Rossii. Klinicheskaya farmakologiya i terapiya. 2001; 10(2):55-58.]</mixed-citation><mixed-citation xml:lang="en">Бутрова СА. Сибутрамин (Меридиа) в лечении ожирения: опыт применения в России. Клиническая фармакология и терапия. 2001;10(2):55-58.[Butrova SA. Sibutramin (Meridia) v lechenii ozhireniya: opyt primeneniya v Rossii. Klinicheskaya farmakologiya i terapiya. 2001; 10(2):55-58.]</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Sjöström CD, Lystig T, Lindroos AK. Impact of weight change, secular trends and ageing on cardiovascular risk factors: 10-year experiences from the SOS study.. Int J Obes (Lond) 2011;35(11):1413-1420. Available from: http://www.nlm.nih.gov/medlineplus/obesity.html PubMed PMID: 21266948. doi: 10.1038/ijo.2010.282.</mixed-citation><mixed-citation xml:lang="en">Sjöström CD, Lystig T, Lindroos AK. Impact of weight change, secular trends and ageing on cardiovascular risk factors: 10-year experiences from the SOS study.. Int J Obes (Lond) 2011;35(11):1413-1420. Available from: http://www.nlm.nih.gov/medlineplus/obesity.html PubMed PMID: 21266948. doi: 10.1038/ijo.2010.282.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Rashid P, Leonardi-Bee J, Bath P. Blood Pressure Reduction and Secondary Prevention of Stroke and Other Vascular Events: A Systematic Review. Stroke 2003;34(11):2741-2748. Available from: http://stroke.ahajournals.org/cgi/doi/10.1161/01.STR.0000092488.40085.15 doi: 10.1161/01.STR.0000092488.40085.15.</mixed-citation><mixed-citation xml:lang="en">Rashid P, Leonardi-Bee J, Bath P. Blood Pressure Reduction and Secondary Prevention of Stroke and Other Vascular Events: A Systematic Review. Stroke 2003;34(11):2741-2748. Available from: http://stroke.ahajournals.org/cgi/doi/10.1161/01.STR.0000092488.40085.15 doi: 10.1161/01.STR.0000092488.40085.15.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Farrell B, Godwin J, Richards S, Warlow C. The United Kingdom transient ischaemic attack (UK-TIA) aspirin trial: final results. Journal of Neurology, Neurosurgery and Psychiatry 1991;54(12):1044-1054. Available from: http://jnnp.bmj.com/cgi/doi/10.1136/jnnp.54.12.1044 PubMed PMID: 1783914. doi: 10.1136/jnnp.54.12.1044.</mixed-citation><mixed-citation xml:lang="en">Farrell B, Godwin J, Richards S, Warlow C. The United Kingdom transient ischaemic attack (UK-TIA) aspirin trial: final results. Journal of Neurology, Neurosurgery and Psychiatry 1991;54(12):1044-1054. Available from: http://jnnp.bmj.com/cgi/doi/10.1136/jnnp.54.12.1044 PubMed PMID: 1783914. doi: 10.1136/jnnp.54.12.1044.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Lawes CM, Rodgers A, Bennett DA, Parag V, Suh I, Ueshima H, et al. Blood pressure and cardiovascular disease in the Asia Pacific region. J Hypertens 2003;21(4):707-716.</mixed-citation><mixed-citation xml:lang="en">Lawes CM, Rodgers A, Bennett DA, Parag V, Suh I, Ueshima H, et al. Blood pressure and cardiovascular disease in the Asia Pacific region. J Hypertens 2003;21(4):707-716.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Оюунчимэг Я, Самойлова ЮГ, Кошевец ТЮ. Клинический подход к оценке качества жизни у больных сахарным диабетом типа 2. Бюллетень сибирской медицины. 2009; (2):72-76. [Oyuunchimeg Ya, Samoylova YuG, Koshevets TYu. Clinical approach to assessment of the life quality in type 2 diabetes patients. Bulletin of Siberian medicine. 2009; (2):72-76.]</mixed-citation><mixed-citation xml:lang="en">Оюунчимэг Я, Самойлова ЮГ, Кошевец ТЮ. Клинический подход к оценке качества жизни у больных сахарным диабетом типа 2. Бюллетень сибирской медицины. 2009; (2):72-76. [Oyuunchimeg Ya, Samoylova YuG, Koshevets TYu. Clinical approach to assessment of the life quality in type 2 diabetes patients. Bulletin of Siberian medicine. 2009; (2):72-76.]</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Brown N, Melville M, Gray D, Young T, Munro J, Skene AM, et al. Quality of life four years after acute myocardial infarction: short form 36 scores compared with a normal population. Heart 1999;81(4):352-358. PubMed PMID: 10092560.</mixed-citation><mixed-citation xml:lang="en">Brown N, Melville M, Gray D, Young T, Munro J, Skene AM, et al. Quality of life four years after acute myocardial infarction: short form 36 scores compared with a normal population. Heart 1999;81(4):352-358. PubMed PMID: 10092560.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Гусев ЕИ, Чуканова ЕИ. Клиническая эффективность и фармакоэкономика лечения пациентов с острым ишемическим инсультом препаратом Церебролизин. Обозрение психиатрии и медицинской психологии им. В.М Бехтерева. 2011;(2):34-41. [Gusev KI, Chukanova KI. Clinical efficacy and pharmacoeconomics of Cerebrolysin treatment of patients with acute ischaemic stroke. V.M. Bekhterev Review Of Psychiatry And Medical Psychology. 2011;(2):34-41.]</mixed-citation><mixed-citation xml:lang="en">Гусев ЕИ, Чуканова ЕИ. Клиническая эффективность и фармакоэкономика лечения пациентов с острым ишемическим инсультом препаратом Церебролизин. Обозрение психиатрии и медицинской психологии им. В.М Бехтерева. 2011;(2):34-41. [Gusev KI, Chukanova KI. Clinical efficacy and pharmacoeconomics of Cerebrolysin treatment of patients with acute ischaemic stroke. V.M. Bekhterev Review Of Psychiatry And Medical Psychology. 2011;(2):34-41.]</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Митьковская НП, Скугаревский ОА, Статкевич ТВ, Супрун ВЕ, Патеюк ИВ, Петрова ЕБ, и соав. Психоэмоциональный статус и клинико-лабораторная характеристика больных инфарктом миокарда при наличии неблагоприятной кластеризации кардиоваскулярных факторов риска. Медицинский журнал. 2010;(1):58-62. [Mit'kovskaya NP, Skugarevskiy OA, Statkevich TV, Suprun VE, Pateyuk IV, Petrova EB, et al. Psikhoemotsional'nyy status i kliniko-laboratornaya kharakteristika bol'nykh infarktom miokarda pri nalichii neblagopriyatnoy klasterizatsii kardiovaskulyarnykh faktorov riska. Meditsinskii zhurnal. 2010;(1):58-62.]</mixed-citation><mixed-citation xml:lang="en">Митьковская НП, Скугаревский ОА, Статкевич ТВ, Супрун ВЕ, Патеюк ИВ, Петрова ЕБ, и соав. Психоэмоциональный статус и клинико-лабораторная характеристика больных инфарктом миокарда при наличии неблагоприятной кластеризации кардиоваскулярных факторов риска. Медицинский журнал. 2010;(1):58-62. [Mit'kovskaya NP, Skugarevskiy OA, Statkevich TV, Suprun VE, Pateyuk IV, Petrova EB, et al. Psikhoemotsional'nyy status i kliniko-laboratornaya kharakteristika bol'nykh infarktom miokarda pri nalichii neblagopriyatnoy klasterizatsii kardiovaskulyarnykh faktorov riska. Meditsinskii zhurnal. 2010;(1):58-62.]</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Белоусов ДЮ, Афанасьева ЕВ, Бекетов АС, Белоусов ЮБ. Прогнозирование влияния статинов на прямые медицинские затраты при вторичной профилактике у пациентов с высоким риском развития сердечно-сосудистых заболеваний. Качественная клиническая практика. 2011;1:97-115.[Belousov DYu, Afanas'eva EV, Beketov AS, Belousov YuB. Prognozirovanie vliyaniya statinov na pryamye meditsinskie zatraty pri vtorichnoy profilaktike u patsientov s vysokim riskom razvitiya serdechno-sosudistykh zabolevaniy. Kachestvennaya klinicheskaya praktika. 2011;1:97-115.]</mixed-citation><mixed-citation xml:lang="en">Белоусов ДЮ, Афанасьева ЕВ, Бекетов АС, Белоусов ЮБ. Прогнозирование влияния статинов на прямые медицинские затраты при вторичной профилактике у пациентов с высоким риском развития сердечно-сосудистых заболеваний. Качественная клиническая практика. 2011;1:97-115.[Belousov DYu, Afanas'eva EV, Beketov AS, Belousov YuB. Prognozirovanie vliyaniya statinov na pryamye meditsinskie zatraty pri vtorichnoy profilaktike u patsientov s vysokim riskom razvitiya serdechno-sosudistykh zabolevaniy. Kachestvennaya klinicheskaya praktika. 2011;1:97-115.]</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Сунцов ЮИ, Дедов ИИ. Государственный регистр больных сахарным диабетом – основная информационная система для расчета экономических затрат государства на сахарный диабет и их прогнозирование. Сахарный диабет. 2005;(2):2-5. [Suntsov YI, Dedov II. Gosudarstvennyy registr bol'nykh sakharnym diabetom - osnovnayainformatsionnnaya sistema dlya rascheta ekonomicheskikh zatratgosudarstva na sakharnyy diabet i ikh prognozirovanie. Diabetes mellitus 2005; (2):2-5.] DOI: 10.14341/2072-0351-5773</mixed-citation><mixed-citation xml:lang="en">Сунцов ЮИ, Дедов ИИ. Государственный регистр больных сахарным диабетом – основная информационная система для расчета экономических затрат государства на сахарный диабет и их прогнозирование. Сахарный диабет. 2005;(2):2-5. [Suntsov YI, Dedov II. Gosudarstvennyy registr bol'nykh sakharnym diabetom - osnovnayainformatsionnnaya sistema dlya rascheta ekonomicheskikh zatratgosudarstva na sakharnyy diabet i ikh prognozirovanie. Diabetes mellitus 2005; (2):2-5.] DOI: 10.14341/2072-0351-5773</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">O’Meara S, Riemsma R, Shirran L, Mather L, ter Riet G. A systematic review of the clinical effectiveness and costeffectiveness of orlistat in the management of obesity. Report commissioned by the NHS R&amp;D HTA Programme on behalf of The National Institute for Clinical Exellence (NICE). 2000. Available from: http://www.nice.org.uk.</mixed-citation><mixed-citation xml:lang="en">O’Meara S, Riemsma R, Shirran L, Mather L, ter Riet G. A systematic review of the clinical effectiveness and costeffectiveness of orlistat in the management of obesity. Report commissioned by the NHS R&amp;D HTA Programme on behalf of The National Institute for Clinical Exellence (NICE). 2000. Available from: http://www.nice.org.uk.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Goldman DP, Zheng Y, Girosi F, Michaud P, Olshansky SJ, Cutler D. The Benefits of Risk Factor Prevention in Americans Aged 51 Years and Older. Am J Public Health 2009;99(11):2096-2101. Available from: http://ajph.aphapublications.org/doi/abs/10.2105/AJPH.2009.172627 doi: 10.2105/AJPH.2009.172627.</mixed-citation><mixed-citation xml:lang="en">Goldman DP, Zheng Y, Girosi F, Michaud P, Olshansky SJ, Cutler D. The Benefits of Risk Factor Prevention in Americans Aged 51 Years and Older. Am J Public Health 2009;99(11):2096-2101. Available from: http://ajph.aphapublications.org/doi/abs/10.2105/AJPH.2009.172627 doi: 10.2105/AJPH.2009.172627.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Franco OH. Cost effectiveness of statins in coronary heart disease. Journal of Epidemiology &amp;amp; Community Health 2005;59(11):927-933. Available from: http://jech.bmj.com/cgi/doi/10.1136/jech.2005.034900 doi: 10.1136/jech.2005.034900.</mixed-citation><mixed-citation xml:lang="en">Franco OH. Cost effectiveness of statins in coronary heart disease. Journal of Epidemiology &amp;amp; Community Health 2005;59(11):927-933. Available from: http://jech.bmj.com/cgi/doi/10.1136/jech.2005.034900 doi: 10.1136/jech.2005.034900.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Куликов АЮ. Практические аспекты оценки качества жизни. V конгресс с международным участием «Развитие фармакоэкономики и фармакоэпидемиологии в РФ»; 1-2 марта 2011 года; Самара. [Kulikov AYu. Prakticheskie aspekty otsenki kachestva zhizni. V kongress s mezhdunarodnym uchastiem «Razvitie farmakoekonomiki i farmakoepidemiologii v RF»; 1-2 marta 2011 goda; Samara.]</mixed-citation><mixed-citation xml:lang="en">Куликов АЮ. Практические аспекты оценки качества жизни. V конгресс с международным участием «Развитие фармакоэкономики и фармакоэпидемиологии в РФ»; 1-2 марта 2011 года; Самара. [Kulikov AYu. Prakticheskie aspekty otsenki kachestva zhizni. V kongress s mezhdunarodnym uchastiem «Razvitie farmakoekonomiki i farmakoepidemiologii v RF»; 1-2 marta 2011 goda; Samara.]</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
