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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/DM2014241-46</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-6407</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Кардиология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Cardiology</subject></subj-group></article-categories><title-group><article-title>Состояние сердца и сосудов при кардиоваскулярной форме автономной нейропатии у больных сахарным диабетом 2 типа</article-title><trans-title-group xml:lang="en"><trans-title>Morphological and functional parameters of the heart and vessels in patients with type 2 diabetes mellitus and cardiovascular autonomic neuropathy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бондарь</surname><given-names>Ирина Аркадьевна</given-names></name><name name-style="western" xml:lang="en"><surname>Bondar'</surname><given-names>Irina Arkad'evna</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор, заведующий кафедрой эндокринологии ГБОУ ВПО «Новосибирский Государственный медицинский университет», Новосибирск</p></bio><bio xml:lang="en"><p>MD, PhD, Professor, Head of the Endocrinology department in Novosibirsk State Medical University</p></bio><email xlink:type="simple">bondaria@oblmed.nsk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Демин</surname><given-names>Александр Аристархович</given-names></name><name name-style="western" xml:lang="en"><surname>Demin</surname><given-names>Alexander Aristarkhovich</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор, заведующий кафедрой госпитальной терапии и клинической фармакологии лечебного факультета ГБОУ ВПО «Новосибирский Государственный медицинский университет», Новосибирск</p></bio><bio xml:lang="en"><p>MD, PhD, Professor, Head of the Internal Medicine and Clinical Pharmacology department of the Medical Faculty in Novosibirsk State Medical University</p></bio><email xlink:type="simple">bondaria@oblmed.nsk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шабельникова</surname><given-names>Олеся Юрьевна</given-names></name><name name-style="western" xml:lang="en"><surname>Shabel'nikova</surname><given-names>Olesya Yur'evna</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, руководитель областного диабетологического центра, ГБУЗ НСО «Новосибирская областная клиническая больница», Новосибирск</p></bio><bio xml:lang="en"><p>MD, PhD, head of the Novosibirsk State Regional Hospital</p></bio><email xlink:type="simple">odc@oblmed.nsk.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО «Новосибирский Государственный медицинский университет" Минзрава России, Новосибирск</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University, Novosibirsk</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ НСО «Новосибирская областная клиническая больница», Новосибирск</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Regional Hospital, Novosibirsk</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>21</day><month>04</month><year>2014</year></pub-date><volume>17</volume><issue>2</issue><fpage>41</fpage><lpage>46</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бондарь И.А., Демин А.А., Шабельникова О.Ю., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Бондарь И.А., Демин А.А., Шабельникова О.Ю.</copyright-holder><copyright-holder xml:lang="en">Bondar' I.A., Demin A.A., Shabel'nikova O.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/6407">https://www.dia-endojournals.ru/jour/article/view/6407</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>сахарный диабет</kwd><kwd>сердце</kwd><kwd>кардиоваскулярная автономная нейропатия</kwd><kwd>детерминанты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>diabetes mellitus</kwd><kwd>heart</kwd><kwd>cardiovascular autonomic neuropathy</kwd><kwd>determinants</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">ГБУЗ НСО Государственная Новосибирская областная клиническая больница</funding-statement><funding-statement xml:lang="en">Novosibirsk State Regional Hospital, Novosibirsk</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Статистические материалы министерства здравоохранения и социального развития Российской Федерации. М; 2003. [Statistical Materials of the Ministry of Health and Social Development of the Russian Federation. Moscow; 2003.]</mixed-citation><mixed-citation xml:lang="en">Статистические материалы министерства здравоохранения и социального развития Российской Федерации. М; 2003. [Statistical Materials of the Ministry of Health and Social Development of the Russian Federation. Moscow; 2003.]</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Бондарь ИА, Демин АА, Королева ЕА. Диабетическая автономная нейропатия. Новосибирск; 2006. [Bondar' IA, Demin AA, Koroleva EA. Diabetic autonomic neuropathy. Novosibirsk; 2006.]</mixed-citation><mixed-citation xml:lang="en">Бондарь ИА, Демин АА, Королева ЕА. Диабетическая автономная нейропатия. Новосибирск; 2006. [Bondar' IA, Demin AA, Koroleva EA. Diabetic autonomic neuropathy. Novosibirsk; 2006.]</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Tesfaye S, Chaturvedi N, Eaton SEM, Ward JD, Manes C, Ionescu-Tirgoviste C, et al. Vascular Risk Factors and Diabetic Neuropathy. N Engl J Med 2005 Jan;352(4):341-350. Available from: http://www.nejm.org/doi/abs/10.1056/NEJMoa032782 PubMed PMID: 15673800. doi: 10.1056/NEJMoa032782.</mixed-citation><mixed-citation xml:lang="en">Tesfaye S, Chaturvedi N, Eaton SEM, Ward JD, Manes C, Ionescu-Tirgoviste C, et al. Vascular Risk Factors and Diabetic Neuropathy. N Engl J Med 2005 Jan;352(4):341-350. Available from: http://www.nejm.org/doi/abs/10.1056/NEJMoa032782 PubMed PMID: 15673800. doi: 10.1056/NEJMoa032782.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Vinik AI, Ziegler D. Diabetic Cardiovascular Autonomic Neuropathy. 2007;115(3):387-397. Available from: http://circ.ahajournals.org/cgi/doi/10.1161/CIRCULATIONAHA.106.634949 doi: 10.1161/CIRCULATIONAHA.106.634949.</mixed-citation><mixed-citation xml:lang="en">Vinik AI, Ziegler D. Diabetic Cardiovascular Autonomic Neuropathy. 2007;115(3):387-397. Available from: http://circ.ahajournals.org/cgi/doi/10.1161/CIRCULATIONAHA.106.634949 doi: 10.1161/CIRCULATIONAHA.106.634949.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ziegler D, Zentai C, Perz S, Rathmann W, Haastert B, Meisinger C, et al. Selective contribution of diabetes and other cardiovascular risk factors to cardiac autonomic dysfunction in the general population. Exp Clin Endocrinol Diabetes 2006;114(4):153-159. Available from: http://www.nlm.nih.gov/medlineplus/diabetescomplications.html PubMed PMID: 16710813. doi: 10.1055/s-2006-924083.</mixed-citation><mixed-citation xml:lang="en">Ziegler D, Zentai C, Perz S, Rathmann W, Haastert B, Meisinger C, et al. Selective contribution of diabetes and other cardiovascular risk factors to cardiac autonomic dysfunction in the general population. Exp Clin Endocrinol Diabetes 2006;114(4):153-159. Available from: http://www.nlm.nih.gov/medlineplus/diabetescomplications.html PubMed PMID: 16710813. doi: 10.1055/s-2006-924083.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Kempler P. Neuropathies. Pathomechanism, clinical presentation, diagnosis, therapy. Springer; 2002.</mixed-citation><mixed-citation xml:lang="en">Kempler P. Neuropathies. Pathomechanism, clinical presentation, diagnosis, therapy. Springer; 2002.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bertoni AG, Tsai A, Kasper EK, Brancati FL. Diabetes and idiopathic cardiomyopathy: a nationwide case-control study. Diabetes Care 2003;26(10):2791-2795. Available from: http://care.diabetesjournals.org/cgi/doi/10.2337/diacare.26.10.2791 PubMed PMID: 14514581. doi: 10.2337/diacare.26.10.2791.</mixed-citation><mixed-citation xml:lang="en">Bertoni AG, Tsai A, Kasper EK, Brancati FL. Diabetes and idiopathic cardiomyopathy: a nationwide case-control study. Diabetes Care 2003;26(10):2791-2795. Available from: http://care.diabetesjournals.org/cgi/doi/10.2337/diacare.26.10.2791 PubMed PMID: 14514581. doi: 10.2337/diacare.26.10.2791.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Karamitsos TD, Karvounis HI, Didangelos T, Parcharidis GE, Karamitsos DT. Impact of autonomic neuropathy on left ventricular function in normotensive type 1 diabetic patients: a tissue Doppler echocardiographic study. Diabetes Care 2008;31(2):325-327. Available from: http://care.diabetesjournals.org/cgi/doi/10.2337/dc07 PubMed PMID: 18000173. doi: 10.2337/dc07-1634.</mixed-citation><mixed-citation xml:lang="en">Karamitsos TD, Karvounis HI, Didangelos T, Parcharidis GE, Karamitsos DT. Impact of autonomic neuropathy on left ventricular function in normotensive type 1 diabetic patients: a tissue Doppler echocardiographic study. Diabetes Care 2008;31(2):325-327. Available from: http://care.diabetesjournals.org/cgi/doi/10.2337/dc07 PubMed PMID: 18000173. doi: 10.2337/dc07-1634.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Аметов АС, Сокарева ЕВ, Гиляревский СР, Дикова ТЕ. Диастолическая дисфункция левого желудочка у больных сахарным диабетом 2 типа. Сахарный диабет. 2008; (1):40–44. [Ametov AS, Sokareva EV, Gilyarevskiy SR, Dikova TE. Diastolicheskaya disfunktsiya levogo zheludochkau bol'nykh sakharnym diabetom 2 tipa. Diabetes mellitus. 2008;(1):40-44] DOI: http://dx.doi.org/10.14341/2072-0351-5944</mixed-citation><mixed-citation xml:lang="en">Аметов АС, Сокарева ЕВ, Гиляревский СР, Дикова ТЕ. Диастолическая дисфункция левого желудочка у больных сахарным диабетом 2 типа. Сахарный диабет. 2008; (1):40–44. [Ametov AS, Sokareva EV, Gilyarevskiy SR, Dikova TE. Diastolicheskaya disfunktsiya levogo zheludochkau bol'nykh sakharnym diabetom 2 tipa. Diabetes mellitus. 2008;(1):40-44] DOI: http://dx.doi.org/10.14341/2072-0351-5944</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Redfield MM, Jacobsen SJ, Burnett Jr, John C , Mahoney DW, Bailey KR, Rodeheffer RJ. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. JAMA 2003;289(2):194-202. Available from: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.289.2.194 PubMed PMID: 12517230. doi: 10.1001/jama.289.2.194.</mixed-citation><mixed-citation xml:lang="en">Redfield MM, Jacobsen SJ, Burnett Jr, John C , Mahoney DW, Bailey KR, Rodeheffer RJ. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. JAMA 2003;289(2):194-202. Available from: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.289.2.194 PubMed PMID: 12517230. doi: 10.1001/jama.289.2.194.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Farhangkhoee H, Khan ZA, Mukherjee S, Cukiernik M, Barbin YP, Karmazyn M, et al. Heme oxygenase in diabetes-induced oxidative stress in the heart. J Mol Cell Cardiol 2003;35(12):1439-1448. doi: 10.1016/j.yjmcc.2003.09.007.</mixed-citation><mixed-citation xml:lang="en">Farhangkhoee H, Khan ZA, Mukherjee S, Cukiernik M, Barbin YP, Karmazyn M, et al. Heme oxygenase in diabetes-induced oxidative stress in the heart. J Mol Cell Cardiol 2003;35(12):1439-1448. doi: 10.1016/j.yjmcc.2003.09.007.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Adeghate E. Molecular and cellular basis of the aetiology and management of diabetic cardiomyopathy: a short review. Mol Cell Biochem 2004;261(1-2):187-191.</mixed-citation><mixed-citation xml:lang="en">Adeghate E. Molecular and cellular basis of the aetiology and management of diabetic cardiomyopathy: a short review. Mol Cell Biochem 2004;261(1-2):187-191.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Shulman GI. Cellular mechanisms of insulin resistance. J. Clin. Invest 2000;106(2):171-176. Available from: http://www.jci.org/articles/view/10583 doi: 10.1172/JCI10583.</mixed-citation><mixed-citation xml:lang="en">Shulman GI. Cellular mechanisms of insulin resistance. J. Clin. Invest 2000;106(2):171-176. Available from: http://www.jci.org/articles/view/10583 doi: 10.1172/JCI10583.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Kim JK, Kim YJ, Fillmore JJ, Chen Y, Moore I, Lee J, et al. Prevention of fat-induced insulin resistance by salicylate. J Clin Invest 2001;108(3):437-446. Available from: http://europepmc.org/abstract/MED/11489937 PubMed PMID: 11489937. doi: 10.1172/JCI11559.</mixed-citation><mixed-citation xml:lang="en">Kim JK, Kim YJ, Fillmore JJ, Chen Y, Moore I, Lee J, et al. Prevention of fat-induced insulin resistance by salicylate. J Clin Invest 2001;108(3):437-446. Available from: http://europepmc.org/abstract/MED/11489937 PubMed PMID: 11489937. doi: 10.1172/JCI11559.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">DeFronzo RA. The effect of insulin on renal sodium metabolism. A review with clinical implications. Diabetologia 1981;21(3):165-171. Available from: http://link.springer.com/10.1007/BF00252649 doi: 10.1007/BF00252649.</mixed-citation><mixed-citation xml:lang="en">DeFronzo RA. The effect of insulin on renal sodium metabolism. A review with clinical implications. Diabetologia 1981;21(3):165-171. Available from: http://link.springer.com/10.1007/BF00252649 doi: 10.1007/BF00252649.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Witteles RM, Fowler MB. Insulin-resistant cardiomyopathy clinical evidence, mechanisms, and treatment options. Journal of the American College of Cardiology 2008;51(2):93-102. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0735109707035085 PubMed PMID: 18191731. doi: 10.1016/j.jacc.2007.10.021.</mixed-citation><mixed-citation xml:lang="en">Witteles RM, Fowler MB. Insulin-resistant cardiomyopathy clinical evidence, mechanisms, and treatment options. Journal of the American College of Cardiology 2008;51(2):93-102. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0735109707035085 PubMed PMID: 18191731. doi: 10.1016/j.jacc.2007.10.021.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Sasaki T, Watanabe M, Nagai Y, Hoshi T, Takasawa M, Nukata M, et al. Association of Plasma Homocysteine Concentration With Atherosclerotic Carotid Plaques and Lacunar Infarction. Stroke 2002;33(6):1493-1496. Available from: http://stroke.ahajournals.org/cgi/doi/10.1161/01.STR.0000016463.01398.D0 doi: 10.1161/01.STR.0000016463.01398.D0.</mixed-citation><mixed-citation xml:lang="en">Sasaki T, Watanabe M, Nagai Y, Hoshi T, Takasawa M, Nukata M, et al. Association of Plasma Homocysteine Concentration With Atherosclerotic Carotid Plaques and Lacunar Infarction. Stroke 2002;33(6):1493-1496. Available from: http://stroke.ahajournals.org/cgi/doi/10.1161/01.STR.0000016463.01398.D0 doi: 10.1161/01.STR.0000016463.01398.D0.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Simon A, Gariepy J, Chironi G, Megnien JL, Levenson J. Intima-media thickness: a new tool for diagnosis and treatment of cardiovascular risk. J Hypertens 2002;20(2):159-169. Available from: http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&amp;an=00004872-200202000-00001 doi: 10.1097/00004872-200202000-00001.</mixed-citation><mixed-citation xml:lang="en">Simon A, Gariepy J, Chironi G, Megnien JL, Levenson J. Intima-media thickness: a new tool for diagnosis and treatment of cardiovascular risk. J Hypertens 2002;20(2):159-169. Available from: http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&amp;an=00004872-200202000-00001 doi: 10.1097/00004872-200202000-00001.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Marinchev A, Kamenova P. Relationship of insulin sensitivity with carotid intima media thickness in patients with type 2 diabetes mellitus. Endocrine Abstracts 2008;16:209.</mixed-citation><mixed-citation xml:lang="en">Marinchev A, Kamenova P. Relationship of insulin sensitivity with carotid intima media thickness in patients with type 2 diabetes mellitus. Endocrine Abstracts 2008;16:209.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Malecki MT, Osmenda G, Walus-Miarka M, Skupien J, Cyganek K, Mirkiewicz-Sieradzka B, et al. Retinopathy in type 2 diabetes mellitus is associated with increased intima-media thickness and endothelial dysfunction. Eur J Clin Invest 2008;38(12):925-930. Available from: http://www.nlm.nih.gov/medlineplus/atherosclerosis.html PubMed PMID: 19021717. doi: 10.1111/j.1365-2362.2008.02051.x.</mixed-citation><mixed-citation xml:lang="en">Malecki MT, Osmenda G, Walus-Miarka M, Skupien J, Cyganek K, Mirkiewicz-Sieradzka B, et al. Retinopathy in type 2 diabetes mellitus is associated with increased intima-media thickness and endothelial dysfunction. Eur J Clin Invest 2008;38(12):925-930. Available from: http://www.nlm.nih.gov/medlineplus/atherosclerosis.html PubMed PMID: 19021717. doi: 10.1111/j.1365-2362.2008.02051.x.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
