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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/DM2014121-28</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-6326</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Вопросы патогенеза</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Pathogenesis</subject></subj-group></article-categories><title-group><article-title>Гормонально-метаболические и генетические маркеры чувствительности к метформину при диабете и раке: предсказание и реальность</article-title><trans-title-group xml:lang="en"><trans-title>Hormonal, metabolic and genetic predictors of metformin efficacy in patients with diabetes mellitus and cancer</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Берштейн</surname><given-names>Лев Михайлович</given-names></name><name name-style="western" xml:lang="en"><surname>Bershteyn</surname><given-names>Lev Mikhaylovich</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, профессор, руководитель лаборатории онкоэндокринологии</p></bio><bio xml:lang="en"><p>MD, PhD, Professor, Head of the Onco-endocrinology laboratory</p></bio><email xlink:type="simple">levmb@endocrin.spb.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васильев</surname><given-names>Дмитрий Алексеевич</given-names></name><name name-style="western" xml:lang="en"><surname>Vasil'ev</surname><given-names>Dmitriy Alexeevich</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук, старший научный сотрудник лаборатории онкоэндокринологии</p></bio><bio xml:lang="en"><p>MD, PhD, Senior Researcher, Onco-endocrinology laboratory</p></bio><email xlink:type="simple">dvasilyev@hotmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иевлева</surname><given-names>Аглая Геннадиевна</given-names></name><name name-style="western" xml:lang="en"><surname>Ievleva</surname><given-names>Aglaya Gennadievna</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук, научный сотрудник лаборатории молекулярной онкологии</p></bio><bio xml:lang="en"><p>MD, PhD, Researcher, Onco-endocrinology laboratory</p></bio><email xlink:type="simple">aglayai@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Порошина</surname><given-names>Татьяна Евгеньевна</given-names></name><name name-style="western" xml:lang="en"><surname>Poroshina</surname><given-names>Tatiana Evgen'evna</given-names></name></name-alternatives><bio xml:lang="ru"><p>Врач клинико-лабораторной  диагностики лаборатории эндокринологии</p></bio><bio xml:lang="en"><p>MD, PhD, Phisician in Onco-endocrinology laboratory</p></bio><email xlink:type="simple">levmb@endocrin.spb.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Имянитов</surname><given-names>Евгений Наумович</given-names></name><name name-style="western" xml:lang="en"><surname>Imyanitov</surname><given-names>Evgeny Naumovich</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, профессор, руководитель отдела биологии опухолевого роста</p></bio><bio xml:lang="en"><p>MD, PhD, Professor, Head of the Cancer growth department</p></bio><email xlink:type="simple">evgeny@imyanitov.spb.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Научно-исследовательский институт онкологии им. Н.Н. Петрова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Petrov Research Institute of Oncology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>29</day><month>03</month><year>2014</year></pub-date><volume>17</volume><issue>1</issue><issue-title>2014 №1</issue-title><fpage>21</fpage><lpage>28</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Берштейн Л.М., Васильев Д.А., Иевлева А.Г., Порошина Т.Е., Имянитов Е.Н., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Берштейн Л.М., Васильев Д.А., Иевлева А.Г., Порошина Т.Е., Имянитов Е.Н.</copyright-holder><copyright-holder xml:lang="en">Bershteyn L.M., Vasil'ev D.A., Ievleva A.G., Poroshina T.E., Imyanitov E.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/6326">https://www.dia-endojournals.ru/jour/article/view/6326</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>метформин</kwd><kwd>чувствительность к терапии</kwd><kwd>сахарный диабет 2 типа</kwd><kwd>онкопатология</kwd><kwd>инсулинорезистентность</kwd><kwd>эстрадиол</kwd><kwd>генетические полиморфизмы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>metformin</kwd><kwd>efficacy</kwd><kwd>type 2 diabetes mellitus</kwd><kwd>cancer</kwd><kwd>insulin resistance</kwd><kwd>estradiol</kwd><kwd>single nucleotide polymorphisms</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">1. 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