diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM2013423-27diaendo-6268Research ArticleГенетикаGeneticsСравнительный анализ распределения частот аллелей и генотипов HLA II класса у пациентов с сахарным диабетом 1 типа в отсутствие и в сочетании с аутоиммунным тиреоидитомComparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditisРепинаЕкатерина АлександровнаRepinaEkaterina Alexandrovna

кандидат медицинских наук, старший научный сотрудник лаборатории генетики и клинической иммунологии ФГБУ ЭНЦ

e_repina@mail.ruАтамановаТатьяна МихайловнаAtamanovaTatiana Mikhailovna

кандидат медицинских наук, старший научный сотрудник лаборатории генетики и клинической иммунологии ФГБУ ЭНЦ

e_repina@mail.ruЗвереваЯна СтаниславовнаZverevaYana Stanislavovna

кандидат медицинских наук, старший научный сотрудник лаборатории генетики и клинической иммунологии ФГБУ ЭНЦ

e_repina@mail.ruТишинаЮлия ВладимировнаTishinaYulia Vladimirovna

научный сотрудник лаборатории генетики и клинической иммунологии  ФГБУ ЭНЦ

e_repina@mail.ruПрокофьевСергей АлександровичProkof'evSergey Alexandrovich

кандидат медицинских наук, заведующий лабораторией генетики и клинической иммунологии ФГБУ ЭНЦ

e_repina@mail.ruФГБУ Эндокринологический научный центр Минздрава России, МоскваРоссияEndocrinology Research Centre, MoscowRussian FederationФГБУ Эндокринологический научный центр Минздрава России, МоскваРоссияEndocrinological Research Centre, MoscowRussian Federation2013181220131642327Copyright © Репина Е.А., Атаманова Т.М., Зверева Я.С., Тишина Ю.В., Прокофьев С.А., 20132013Репина Е.А., Атаманова Т.М., Зверева Я.С., Тишина Ю.В., Прокофьев С.А.Repina E.A., Atamanova T.M., Zvereva Y.S., Tishina Y.V., Prokof'ev S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/6268сахарный диабет 1 типааутоиммунный тиреоидитгены HLA II классааллелигенотипыtype 1 diabetes mellitusautoimmune thyroiditisHLA IIallelegenotypeReferencesАлексеев ЛП, Дедов ИИ, Хаитов РМ, Болдырева МН, Шестакова МВ, Петеркова ВА, и др. Клиническая значимость определения HLA-DRB1-генотипов, ассоциированных с предрасположенностью или устойчивостью к сахарному диабету 1 типа в различных этнических группах России. Сахарный диабет. 2007;(2):2–5. [Alekseev L, Dedov I, Khaitov R, Boldyreva M, Shestakova M, Peterkova V, et al. Klinicheskaya znachimost' opredeleniya HLA-DRB1-genotipov, assotsiirovannykhs predraspolozhennost'yu ili ustoychivost'yuk sakharnomu diabetu 1 tipa,v razlichnykh etnicheskikh gruppakh Rossii. Diabetes mellitus. 2007;(2):2–5. doi: 10.14341/2072-0351-5787 ].Алексеев ЛП, Дедов ИИ, Хаитов РМ, Болдырева МН, Шестакова МВ, Петеркова ВА, и др. Клиническая значимость определения HLA-DRB1-генотипов, ассоциированных с предрасположенностью или устойчивостью к сахарному диабету 1 типа в различных этнических группах России. Сахарный диабет. 2007;(2):2–5. [Alekseev L, Dedov I, Khaitov R, Boldyreva M, Shestakova M, Peterkova V, et al. Klinicheskaya znachimost' opredeleniya HLA-DRB1-genotipov, assotsiirovannykhs predraspolozhennost'yu ili ustoychivost'yuk sakharnomu diabetu 1 tipa,v razlichnykh etnicheskikh gruppakh Rossii. Diabetes mellitus. 2007;(2):2–5. doi: 10.14341/2072-0351-5787 ].Дедов ИИ, Шестакова МВ. Сахарный диабет. Руководство для врачей. Москва: Универсум Паблишинг. 2003. С. 77–81. [Dedov II, Shestakova MV. Diabetes mellitus. Guidelines for Physicians. Moscow: Universum Publishing; 2003.]Дедов ИИ, Шестакова МВ. Сахарный диабет. Руководство для врачей. Москва: Универсум Паблишинг. 2003. С. 77–81. [Dedov II, Shestakova MV. Diabetes mellitus. Guidelines for Physicians. Moscow: Universum Publishing; 2003.]Becker KG, Simon RM, Bailey-Wilson JE, Freidlin B, Biddison WE, McFarland HF, et al. Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases. Proceedings of the National Academy of Sciences. 1998;95(17):9979–9984. DOI: 10.1073/pnas.95.17.9979Becker KG, Simon RM, Bailey-Wilson JE, Freidlin B, Biddison WE, McFarland HF, et al. Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases. Proceedings of the National Academy of Sciences. 1998;95(17):9979–9984. DOI: 10.1073/pnas.95.17.9979Encinas JA, Kuchroo VK. Mapping and identification of autoimmunity genes. Curr Opin Immunol 2000;12(6):691–697. DOI: 10.1016/S0952-7915(00)Encinas JA, Kuchroo VK. Mapping and identification of autoimmunity genes. Curr Opin Immunol 2000;12(6):691–697. DOI: 10.1016/S0952-7915(00)Bias WB, Reveille JD, Beaty TH, Meyers DA, Arnett FC. Evidence that autoimmunity in man is a Mendelian dominant trait. The American Journal of Human Genetics. 1986;39(5):584–602.Bias WB, Reveille JD, Beaty TH, Meyers DA, Arnett FC. Evidence that autoimmunity in man is a Mendelian dominant trait. The American Journal of Human Genetics. 1986;39(5):584–602.McCanlies E, O'Leary LA, Foley TP, Kramer MK, Burke JP, Libman A, et al. Hashimoto's thyroiditis and insulin-dependent diabetes mellitus: differences among individuals with and without abnormal thyroid function. J Clin. Endocrinol Metab. 1998;1998(5):1548–1551. DOI: 10.1210/jc.83.5.1548McCanlies E, O'Leary LA, Foley TP, Kramer MK, Burke JP, Libman A, et al. Hashimoto's thyroiditis and insulin-dependent diabetes mellitus: differences among individuals with and without abnormal thyroid function. J Clin. Endocrinol Metab. 1998;1998(5):1548–1551. DOI: 10.1210/jc.83.5.1548Dittmar M, Kahaly GJ. Polyglandular autoimmune syndromes: immunogenetics and long-term follow-up. J Clin Endocrinol Metab 2003;88(7):2983–2992. DOI: 10.1210/jc.2002-021845Dittmar M, Kahaly GJ. Polyglandular autoimmune syndromes: immunogenetics and long-term follow-up. J Clin Endocrinol Metab 2003;88(7):2983–2992. DOI: 10.1210/jc.2002-021845Levin L, Tomer Y. The etiology of autoimmune diabetes and thyroiditis: evidence for common genetic susceptibility Autoimmunity Reviews. 2003;2(6):377–386. DOI: 10.1016/S1568-9972(03)00080-6Levin L, Tomer Y. The etiology of autoimmune diabetes and thyroiditis: evidence for common genetic susceptibility Autoimmunity Reviews. 2003;2(6):377–386. DOI: 10.1016/S1568-9972(03)00080-6Huber A, Menconi F, Corathers S, Jacobson EM, Tomer Y. Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocrine Review. 2008;29(6):697–725. DOI: 10.1210/er.2008-0015Huber A, Menconi F, Corathers S, Jacobson EM, Tomer Y. Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocrine Review. 2008;29(6):697–725. DOI: 10.1210/er.2008-0015Репина ЕА. Общие генетические маркеры сахарного диабета 1 типа и аутоиммунных заболеваний щитовидной железы. Сахарный диабет. 2011;(2):23–30. [Repina E. The role of common genetic markers in susceptibility to type 1 diabetes and autoimmune thyroid diseases. Diabetes mellitus. 2011;(2):23-31. DOI: 10.14341/2072-0351-5630 ]Репина ЕА. Общие генетические маркеры сахарного диабета 1 типа и аутоиммунных заболеваний щитовидной железы. Сахарный диабет. 2011;(2):23–30. [Repina E. The role of common genetic markers in susceptibility to type 1 diabetes and autoimmune thyroid diseases. Diabetes mellitus. 2011;(2):23-31. DOI: 10.14341/2072-0351-5630 ]Burek CL, Rose NR, Guire KE, Hoffman WH. Thyroid autoantibodies in black and in white children and adolescents with type 1 diabetes mellitus and their first degree relatives Autoimmunity. 1990;7(2–3):157–167.Burek CL, Rose NR, Guire KE, Hoffman WH. Thyroid autoantibodies in black and in white children and adolescents with type 1 diabetes mellitus and their first degree relatives Autoimmunity. 1990;7(2–3):157–167.Jaeger C, Hatziagelaki E, Petzoldt R, Bretzel RG. Comparative Analysis of Organ-Specific Autoantibodies and Celiac Disease – Associated Antibodies in Type 1 Diabetic Patients, Their First-Degree Relatives, and Healthy Control Subjects. Diabetes Care. 2001;24(1):27–32. DOI: 10.2337/diacare.24.1.27Jaeger C, Hatziagelaki E, Petzoldt R, Bretzel RG. Comparative Analysis of Organ-Specific Autoantibodies and Celiac Disease – Associated Antibodies in Type 1 Diabetic Patients, Their First-Degree Relatives, and Healthy Control Subjects. Diabetes Care. 2001;24(1):27–32. DOI: 10.2337/diacare.24.1.27Sougioultzoglou F, Falorni A, Kassi G, Brozzetti A, Karamitsos D, Koliakos GG. Coincidence of high antiislet and antithyroid autoantibody titles in first-degree relatives of patients with type 1 diabetes. Experimental and Clinical Endocrinology & Diabetes. 2005; 113(2):85–89. DOI: 10.1055/s-2005-837510.Sougioultzoglou F, Falorni A, Kassi G, Brozzetti A, Karamitsos D, Koliakos GG. Coincidence of high antiislet and antithyroid autoantibody titles in first-degree relatives of patients with type 1 diabetes. Experimental and Clinical Endocrinology & Diabetes. 2005; 113(2):85–89. DOI: 10.1055/s-2005-837510.Kordonouri O, Deiss D, Danne T, Dorow A, Bassir C, Grüters-Kieslich A. Predictivity of thyroid autoantibodies for the development of thyroid disorders in children and adolescents with Type 1 diabetes. Diabet Med. 2002;19(6):518–521. DOI: 10.1046/j.1464-5491.2002.00699.xKordonouri O, Deiss D, Danne T, Dorow A, Bassir C, Grüters-Kieslich A. Predictivity of thyroid autoantibodies for the development of thyroid disorders in children and adolescents with Type 1 diabetes. Diabet Med. 2002;19(6):518–521. DOI: 10.1046/j.1464-5491.2002.00699.xBright GM, Blizzard RM, Kaiser DL, Clarke WL. Organ-specific autoantibodies in children with common endocrine diseases. The Journal of Pediatrics. 1982;100(1):8–14.Bright GM, Blizzard RM, Kaiser DL, Clarke WL. Organ-specific autoantibodies in children with common endocrine diseases. The Journal of Pediatrics. 1982;100(1):8–14.Eisenbarth GS, Gottlieb PA. Autoimmune Polyendocrine Syndromes. New England Journal of Medicine. 2004;350(20):2068–2079. DOI: 10.1056/NEJMra030158Eisenbarth GS, Gottlieb PA. Autoimmune Polyendocrine Syndromes. New England Journal of Medicine. 2004;350(20):2068–2079. DOI: 10.1056/NEJMra030158Wallaschofski H, Meyer A, Tuschy U, Lohmann T. HLA-DQA1*0301-associated susceptibility for autoimmune polyglandular syndrome type II and III. Hormone and Metabolic Research. 2003.;35(2):120–124. DOI: 10.1055/s-2003-39059.Wallaschofski H, Meyer A, Tuschy U, Lohmann T. HLA-DQA1*0301-associated susceptibility for autoimmune polyglandular syndrome type II and III. Hormone and Metabolic Research. 2003.;35(2):120–124. DOI: 10.1055/s-2003-39059.Santamaria P, Barbosa JJ, Lindstrom AL, Lemke TA, Goetz FC, Rich SS. HLA-DQB1-associated susceptibility that distinguishes Hashimoto's thyroiditis from Graves' disease in type I diabetic patients. Journal of Clinical Endocrinology and Metabolism 1994;78(4):878–883. DOI: 10.1210/jc.78.4.878Santamaria P, Barbosa JJ, Lindstrom AL, Lemke TA, Goetz FC, Rich SS. HLA-DQB1-associated susceptibility that distinguishes Hashimoto's thyroiditis from Graves' disease in type I diabetic patients. Journal of Clinical Endocrinology and Metabolism 1994;78(4):878–883. DOI: 10.1210/jc.78.4.878Santamaria P, Barbosa JJ, Lindstrom AL, Lemke TA, Goetz FC, Rich SS. HLA-DQB1-associated susceptibility that distinguishes Hashimoto's thyroiditis from Graves' disease in type I diabetic patients. Journal of Clinical Endocrinology and Metabolism 1994;78(4):878–883. DOI: 10.1210/jc.78.4.878.Santamaria P, Barbosa JJ, Lindstrom AL, Lemke TA, Goetz FC, Rich SS. HLA-DQB1-associated susceptibility that distinguishes Hashimoto's thyroiditis from Graves' disease in type I diabetic patients. Journal of Clinical Endocrinology and Metabolism 1994;78(4):878–883. DOI: 10.1210/jc.78.4.878.Levin L, Ban Y, Concepcion E, Davies TF, Greenberg DA, Tomer Y. Analysis of HLA genes in families with autoimmune diabetes and thyroiditis. Human Immunology. 2004;65(6):640–647. DOI: 10.1016/j.humimm.2004.02.026Levin L, Ban Y, Concepcion E, Davies TF, Greenberg DA, Tomer Y. Analysis of HLA genes in families with autoimmune diabetes and thyroiditis. Human Immunology. 2004;65(6):640–647. DOI: 10.1016/j.humimm.2004.02.026Golden B, Levin L, Ban Y, Concepcion E, Greenberg DA, Tomer Y. Genetic Analysis of Families with Autoimmune Diabetes and Thyroiditis: Evidence for Common and Unique Genes. Journal of Clinical Endocrinology and Metabolism. 2005;90(8):4904–4911. DOI: 10.1210/jc.2004-2236Golden B, Levin L, Ban Y, Concepcion E, Greenberg DA, Tomer Y. Genetic Analysis of Families with Autoimmune Diabetes and Thyroiditis: Evidence for Common and Unique Genes. Journal of Clinical Endocrinology and Metabolism. 2005;90(8):4904–4911. DOI: 10.1210/jc.2004-2236Huang W, Connor E, Rosa TD, Muir A, Schatz D, Silverstein J, et al. Although DR3-DQB1*0201 may be associated with multiple component diseases of the autoimmune polyglandular syndromes, the human leukocyte antigen DR4-DQB1*0302 haplotype is implicated only in beta-cell autoimmunity. Journal of Clinical Endocrinology and Metabolism. 1996;81(7):2559–2563. DOI: 10.1210/jc.81.7.2559Huang W, Connor E, Rosa TD, Muir A, Schatz D, Silverstein J, et al. Although DR3-DQB1*0201 may be associated with multiple component diseases of the autoimmune polyglandular syndromes, the human leukocyte antigen DR4-DQB1*0302 haplotype is implicated only in beta-cell autoimmunity. Journal of Clinical Endocrinology and Metabolism. 1996;81(7):2559–2563. DOI: 10.1210/jc.81.7.2559Holl RW, Bohm B, Loos U, Grabert M, Heinze E, Homoki J. Thyroid autoimmunity in children and adolescents with type 1 diabetes mellitus. Effect of age, gender and HLA type. Hormone Research. 1999;52(3):113–118. DOI: 10.1159/000023446Holl RW, Bohm B, Loos U, Grabert M, Heinze E, Homoki J. Thyroid autoimmunity in children and adolescents with type 1 diabetes mellitus. Effect of age, gender and HLA type. Hormone Research. 1999;52(3):113–118. DOI: 10.1159/000023446Никонова ТВ, Дедов ИИ, Алексеев ЛП, Болдырева МН, Смирнова ОМ, Дубинкин ИВ. Сахарный диабет. 2000;(2):2–5. DOI: [Nikonova T, Dedov I, Alekseev L, Boldyreva M, Smirnova O, Dubinkin I. Prognozirovanie SD 1 tipa v gruppakh vysokogo riska. Diabetes mellitus. 2000;(2):2–6. DOI: 10.14341/2072-0351-5877 ]Никонова ТВ, Дедов ИИ, Алексеев ЛП, Болдырева МН, Смирнова ОМ, Дубинкин ИВ. Сахарный диабет. 2000;(2):2–5. DOI: [Nikonova T, Dedov I, Alekseev L, Boldyreva M, Smirnova O, Dubinkin I. Prognozirovanie SD 1 tipa v gruppakh vysokogo riska. Diabetes mellitus. 2000;(2):2–6. DOI: 10.14341/2072-0351-5877 ]Болдырева МН, Хаитов РМ, Дедов ИИ, Богатова ОВ, Гуськова ИА, Янкевич ТЭ, и др. Новый взгляд на механизм HLA ассоциированной предрасположенности к сахарному диабету 1 типа. Теоретические и прикладные аспекты. Иммунология. 2005;26(6):324–329. [Boldyreva МN, Khaitov RМ, Dedov II, Bogatova ОV, Gus'kova IA, Yankevich ТЕ, et al. New opinion at the mechanism of HLA-associated predisposition to 1 type diabetes: theoretical and applied aspects. Immunology. 2005;26(6):324–329].Болдырева МН, Хаитов РМ, Дедов ИИ, Богатова ОВ, Гуськова ИА, Янкевич ТЭ, и др. Новый взгляд на механизм HLA ассоциированной предрасположенности к сахарному диабету 1 типа. Теоретические и прикладные аспекты. Иммунология. 2005;26(6):324–329. [Boldyreva МN, Khaitov RМ, Dedov II, Bogatova ОV, Gus'kova IA, Yankevich ТЕ, et al. New opinion at the mechanism of HLA-associated predisposition to 1 type diabetes: theoretical and applied aspects. Immunology. 2005;26(6):324–329].

The authors declare that there are no conflicts of interest present.