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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/2072-0351-6177</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-6177</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Современные аспекты патогенеза сахарного диабета 1 типа</article-title><trans-title-group xml:lang="en"><trans-title>Sovremennye aspekty patogenezasakharnogo diabeta 1 tipa</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никонова</surname><given-names>Татьяна Васильевна</given-names></name><name name-style="western" xml:lang="en"><surname>Nikonova</surname><given-names>Tatiana Vasil'evna</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Эндокринологический научный центр РАМН, Москва</institution></aff><aff xml:lang="en"><institution>Endocrinology Research Centre, Moscow</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2006</year></pub-date><pub-date pub-type="epub"><day>15</day><month>09</month><year>2006</year></pub-date><volume>9</volume><issue>3</issue><issue-title>№3 (2006)</issue-title><fpage>59</fpage><lpage>64</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Никонова Т.В., 2006</copyright-statement><copyright-year>2006</copyright-year><copyright-holder xml:lang="ru">Никонова Т.В.</copyright-holder><copyright-holder xml:lang="en">Nikonova T.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/6177">https://www.dia-endojournals.ru/jour/article/view/6177</self-uri><abstract><p>ГУ Эндокринологический научный центр РАМН, Москва</p></abstract><kwd-group xml:lang="ru"><kwd>патогенез</kwd><kwd>сахарный диабет 1 типа</kwd><kwd>лечение</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Мохорт Т.В,, Мельнов С.Б. Горанов В.А. Апоптоз - роль в развитии сахар- ного диабета типа 1. // Пробл. эндокринол. 200. - Т. 46,№ 2. - С. 8-13.</mixed-citation><mixed-citation xml:lang="en">Мохорт Т.В,, Мельнов С.Б. Горанов В.А. Апоптоз - роль в развитии сахар- ного диабета типа 1. // Пробл. эндокринол. 200. - Т. 46,№ 2. - С. 8-13.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Abiru N, Yu L, Redondo M, Elsenbarth GS: Modification of environment is not the most efficient way to prevent type 1 diabetes. Diabetes Technol Ther 2:609-616, 2000</mixed-citation><mixed-citation xml:lang="en">Abiru N, Yu L, Redondo M, Elsenbarth GS: Modification of environment is not the most efficient way to prevent type 1 diabetes. Diabetes Technol Ther 2:609-616, 2000</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Achenbach P, Warncke K, Reiter J, Naserke HE, Williams AJ, Bingley PJ, Bonifacio E, Zeigler AG: Stratification of type 1 diabetes risk on the basis of the islet autoantibody characteristics. Diabetes 53:384-392,2004</mixed-citation><mixed-citation xml:lang="en">Achenbach P, Warncke K, Reiter J, Naserke HE, Williams AJ, Bingley PJ, Bonifacio E, Zeigler AG: Stratification of type 1 diabetes risk on the basis of the islet autoantibody characteristics. Diabetes 53:384-392,2004</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Atkinson M.A. Thirty years of investigating the Autoimmune basis for the type 1 diabetes Diabetes 54^1253-1263, 2005.</mixed-citation><mixed-citation xml:lang="en">Atkinson M.A. Thirty years of investigating the Autoimmune basis for the type 1 diabetes Diabetes 54^1253-1263, 2005.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Atkinson MA, Bowman MA, Campbell L, Darrow BL, Kauffman DL, Maclaren NK: Cellular immunity to a dependent common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J Clin Invest 94: 2125-2129, 1994</mixed-citation><mixed-citation xml:lang="en">Atkinson MA, Bowman MA, Campbell L, Darrow BL, Kauffman DL, Maclaren NK: Cellular immunity to a dependent common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J Clin Invest 94: 2125-2129, 1994</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Atkinson MA, Bowman MA, Kao KJ, Campbell L, Dush PJ, Shah SC, Simell O, Maclaren NK: Lack of immune responsiveness to bovine serum albumin in IDDM. N Engl J Med 329:1853-1858,1993</mixed-citation><mixed-citation xml:lang="en">Atkinson MA, Bowman MA, Kao KJ, Campbell L, Dush PJ, Shah SC, Simell O, Maclaren NK: Lack of immune responsiveness to bovine serum albumin in IDDM. N Engl J Med 329:1853-1858,1993</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Atkinson MA, Eisenbarth GS: Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancel 358:221-229,2001</mixed-citation><mixed-citation xml:lang="en">Atkinson MA, Eisenbarth GS: Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancel 358:221-229,2001</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Atkinson M, Gale EA: Infant diets and type 1 diabetes too early, too late, or just too complicated? JAMA 290:1771 - 1772, 2003</mixed-citation><mixed-citation xml:lang="en">Atkinson M, Gale EA: Infant diets and type 1 diabetes too early, too late, or just too complicated? JAMA 290:1771 - 1772, 2003</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Atkinson MA, Leiter EH: The NOD mouse model of type 1 diabetes: as good as it gets? Nal Med 5: 601-604, 1999</mixed-citation><mixed-citation xml:lang="en">Atkinson MA, Leiter EH: The NOD mouse model of type 1 diabetes: as good as it gets? Nal Med 5: 601-604, 1999</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Athkinson MA, Kaufman DL, Campbell L, Gibbs KA, Shah SC, Bu DF, Erlander MG, Tobin AJ, Maclaren NK: Respons of peripheral-blood mononuclear cells to glutamatedecarboxylase in insulin-dependent diabetes. Lancet 339: 458-459,1992</mixed-citation><mixed-citation xml:lang="en">Athkinson MA, Kaufman DL, Campbell L, Gibbs KA, Shah SC, Bu DF, Erlander MG, Tobin AJ, Maclaren NK: Respons of peripheral-blood mononuclear cells to glutamatedecarboxylase in insulin-dependent diabetes. Lancet 339: 458-459,1992</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Borch-Jonsen K, Mandrup-Poulsen T, Christy M, Zachau- Christansen B, Kastrup K, Nerup J: Relation between breast-feeding and incidence rates of insulin-dependent diabetes mellitus: a hypothesis. Lansel 2:1083- 1086, 1984</mixed-citation><mixed-citation xml:lang="en">Borch-Jonsen K, Mandrup-Poulsen T, Christy M, Zachau- Christansen B, Kastrup K, Nerup J: Relation between breast-feeding and incidence rates of insulin-dependent diabetes mellitus: a hypothesis. Lansel 2:1083- 1086, 1984</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Botazzo GF, Florin-Christensen A, Doniach D: Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 2:179-1283, 1974</mixed-citation><mixed-citation xml:lang="en">Botazzo GF, Florin-Christensen A, Doniach D: Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 2:179-1283, 1974</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bowmann MA, Leiter EH, Atkinson MA: Prevrntion of diabetes in the NOD mouse: implications for therapeutic intervention in human disease. Immunol Today 15: 115-120, 1994</mixed-citation><mixed-citation xml:lang="en">Bowmann MA, Leiter EH, Atkinson MA: Prevrntion of diabetes in the NOD mouse: implications for therapeutic intervention in human disease. Immunol Today 15: 115-120, 1994</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Dahl-Jorgensen k, Joner G, Hanssen KF: Relationship between cow's milk consumption and incidence of IDDM in childhood. Diabetes Care 14:1081-1083,1991</mixed-citation><mixed-citation xml:lang="en">Dahl-Jorgensen k, Joner G, Hanssen KF: Relationship between cow's milk consumption and incidence of IDDM in childhood. Diabetes Care 14:1081-1083,1991</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Daaboul J, Schtz D: Overview of prevention and intervention trials for type 1 diabetes. Rev Endocr Metab Disord 4:317-323, 2003</mixed-citation><mixed-citation xml:lang="en">Daaboul J, Schtz D: Overview of prevention and intervention trials for type 1 diabetes. Rev Endocr Metab Disord 4:317-323, 2003</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Eisenbarth GS: Type 1 diabetes mellitus: a chronic autoimmune disease. N Engl J Med 314: 1360 - 1368, 1986</mixed-citation><mixed-citation xml:lang="en">Eisenbarth GS: Type 1 diabetes mellitus: a chronic autoimmune disease. N Engl J Med 314: 1360 - 1368, 1986</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Eisenbarth GS: Insulin autoimmunity: immunogenetics/ immunopathogenesis of tipe 1 diabetes. Ann NY Acad Sci 1005:109-118,2003</mixed-citation><mixed-citation xml:lang="en">Eisenbarth GS: Insulin autoimmunity: immunogenetics/ immunopathogenesis of tipe 1 diabetes. Ann NY Acad Sci 1005:109-118,2003</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Gepts W: Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14:619-633, 1965</mixed-citation><mixed-citation xml:lang="en">Gepts W: Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14:619-633, 1965</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Greenbraun CJ, Sears KL, Kahn SE, Palmer JP: Relationship of _-cell function and autoantibodies to progression and nonprogression of subclinical type 1 diabetes: flow-up of the Seattle Family Study. Diabetes 48:170-175, 1999</mixed-citation><mixed-citation xml:lang="en">Greenbraun CJ, Sears KL, Kahn SE, Palmer JP: Relationship of _-cell function and autoantibodies to progression and nonprogression of subclinical type 1 diabetes: flow-up of the Seattle Family Study. Diabetes 48:170-175, 1999</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Hahl J, Simell T, Ilonen J, Knip M, Sumell O: Costs of predicting IDDM. Diabetologia 41:79-85,1998</mixed-citation><mixed-citation xml:lang="en">Hahl J, Simell T, Ilonen J, Knip M, Sumell O: Costs of predicting IDDM. Diabetologia 41:79-85,1998</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Holland AM, Gones LJ, Harrison LS: Progenitor cells in the adult pancreas. Diabetes Metab Res Rev 20:13-27,2004</mixed-citation><mixed-citation xml:lang="en">Holland AM, Gones LJ, Harrison LS: Progenitor cells in the adult pancreas. Diabetes Metab Res Rev 20:13-27,2004</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Homo-Delarche F, Drexhage HA: Immune cells, pancreas development, regeneration and type 1 diabetes. Trends Immunol 25:222-229,2004</mixed-citation><mixed-citation xml:lang="en">Homo-Delarche F, Drexhage HA: Immune cells, pancreas development, regeneration and type 1 diabetes. Trends Immunol 25:222-229,2004</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Нyoty H, Taylor KW: The role of viruses in human diabetes. Diabetologia 45:1353-1361,2002</mixed-citation><mixed-citation xml:lang="en">Нyoty H, Taylor KW: The role of viruses in human diabetes. Diabetologia 45:1353-1361,2002</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Ide A, Eisenbarth GS: Genetic susceptibility in type 1 diabetes and its associated autoimmune disorders. Rev Endocr Metab Disord 4:243-253, 2003</mixed-citation><mixed-citation xml:lang="en">Ide A, Eisenbarth GS: Genetic susceptibility in type 1 diabetes and its associated autoimmune disorders. Rev Endocr Metab Disord 4:243-253, 2003</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Karjalainen J, Martin JM, Knip M, Ilonen J, Robinson BH, Savilahti E, Akerblom HK, Dosch HM: A bovine albumin peptide as a possible trigger of IDDM. N Engl J Med 327:302-307, 1992</mixed-citation><mixed-citation xml:lang="en">Karjalainen J, Martin JM, Knip M, Ilonen J, Robinson BH, Savilahti E, Akerblom HK, Dosch HM: A bovine albumin peptide as a possible trigger of IDDM. N Engl J Med 327:302-307, 1992</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Kawasaki E., Abiru N., Eguchi K. // prevention of type 1 diabetes: from the view point of _ cell damage. Diabetes Research and Clinical Practice 66 (2004) S27-S32</mixed-citation><mixed-citation xml:lang="en">Kawasaki E., Abiru N., Eguchi K. // prevention of type 1 diabetes: from the view point of _ cell damage. Diabetes Research and Clinical Practice 66 (2004) S27-S32</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Kukreja A, Marker J, Zhang C, Sun Z, Lin-Su K, Ten S, Sanz M, Exley M, Wilson B, Porcelli S, Maclaren N: Multiple immuno-regulatory defects in type 1 diabetes. J Clin Invest 109:131-140,2002</mixed-citation><mixed-citation xml:lang="en">Kukreja A, Marker J, Zhang C, Sun Z, Lin-Su K, Ten S, Sanz M, Exley M, Wilson B, Porcelli S, Maclaren N: Multiple immuno-regulatory defects in type 1 diabetes. J Clin Invest 109:131-140,2002</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Leiter EH, von Herrath M: Animal models have little to teach us about type 1 diabetes. In opposition of this proposal. Diabetologia 47: 1657- 1660, 2004</mixed-citation><mixed-citation xml:lang="en">Leiter EH, von Herrath M: Animal models have little to teach us about type 1 diabetes. In opposition of this proposal. Diabetologia 47: 1657- 1660, 2004</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Maclaren N, Atkinson M: Is insulin-dependent diabetes mellitus environmentally induced? N Engl J Med 327:348-349, 1992</mixed-citation><mixed-citation xml:lang="en">Maclaren N, Atkinson M: Is insulin-dependent diabetes mellitus environmentally induced? N Engl J Med 327:348-349, 1992</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Martin JM, Trink B, Daneman D, Dosch HM, Robinson B: Milk proteins in the etiology of insulin-dependent diabetes mellitus (IDDM). Ann Med 23:447-452,1991</mixed-citation><mixed-citation xml:lang="en">Martin JM, Trink B, Daneman D, Dosch HM, Robinson B: Milk proteins in the etiology of insulin-dependent diabetes mellitus (IDDM). Ann Med 23:447-452,1991</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Mestas J, Hughes CC: Of mice and not men: differences between mouse and human immunology. J Immunol 172: 2731-2738,2004</mixed-citation><mixed-citation xml:lang="en">Mestas J, Hughes CC: Of mice and not men: differences between mouse and human immunology. J Immunol 172: 2731-2738,2004</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Neel JV: The genetics o f diabetes mellitus. Adv Metab Disord 1 (Suppl. 1):3-10, 11970</mixed-citation><mixed-citation xml:lang="en">Neel JV: The genetics o f diabetes mellitus. Adv Metab Disord 1 (Suppl. 1):3-10, 11970</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Nerup J, Platz P, Andersen OO, Christy M, Lyngsoe J, Poulsen JE, Ryder LP, Nielsen LS, Thomsen M, Svejgaard A: HL-A antigens and diabetes mellitus. Lancet 2:864-866, 1974</mixed-citation><mixed-citation xml:lang="en">Nerup J, Platz P, Andersen OO, Christy M, Lyngsoe J, Poulsen JE, Ryder LP, Nielsen LS, Thomsen M, Svejgaard A: HL-A antigens and diabetes mellitus. Lancet 2:864-866, 1974</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Nooris JM, Barriga K, Klingensmith G, Hoffman M, Eisenbarth GS, Erlich HA, Rewers M: Timing of initial cereal exposure in infancy and risk of islet autoimmunity. JAMA 290:1713-1720, 2003</mixed-citation><mixed-citation xml:lang="en">Nooris JM, Barriga K, Klingensmith G, Hoffman M, Eisenbarth GS, Erlich HA, Rewers M: Timing of initial cereal exposure in infancy and risk of islet autoimmunity. JAMA 290:1713-1720, 2003</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Pugliese A: Genetics of type 1 diabetes. Endocrinol Metab Clin North Am 33:1-16, vii 2004</mixed-citation><mixed-citation xml:lang="en">Pugliese A: Genetics of type 1 diabetes. Endocrinol Metab Clin North Am 33:1-16, vii 2004</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Roep BO: Autoreactive T cells in endocrine organ-specific autoimmunity: why was progress been so slow? Springer Semin Immunopathol 24: 261-271, 2002</mixed-citation><mixed-citation xml:lang="en">Roep BO: Autoreactive T cells in endocrine organ-specific autoimmunity: why was progress been so slow? Springer Semin Immunopathol 24: 261-271, 2002</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Roep BO, Atkinson M: Animal models have little to teach us about type 1 diabetes. In support of this proposal. Diabetologia 47: 1650- 1656,2004</mixed-citation><mixed-citation xml:lang="en">Roep BO, Atkinson M: Animal models have little to teach us about type 1 diabetes. In support of this proposal. Diabetologia 47: 1650- 1656,2004</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Roep BO, Atkinson M, Herrath M: Opinion: satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes. Nat Rev Immunol 4: 989-997,2004</mixed-citation><mixed-citation xml:lang="en">Roep BO, Atkinson M, Herrath M: Opinion: satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes. Nat Rev Immunol 4: 989-997,2004</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Solezs G: Diabetes in the young: a peadiatric and epidemiological perspective. Diabetologia 46:447-454, 2003</mixed-citation><mixed-citation xml:lang="en">Solezs G: Diabetes in the young: a peadiatric and epidemiological perspective. Diabetologia 46:447-454, 2003</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Steele C, Hagopian WA, Gitelman S, Masharani U, Cavaghan M, Rother KI, Donaldson D, Harlan DM, Bluestone J, Herold KC: Insulin secretion in type 1 diabetes. Diabetes 53:426-433, 2004</mixed-citation><mixed-citation xml:lang="en">Steele C, Hagopian WA, Gitelman S, Masharani U, Cavaghan M, Rother KI, Donaldson D, Harlan DM, Bluestone J, Herold KC: Insulin secretion in type 1 diabetes. Diabetes 53:426-433, 2004</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">TIDBase: a bioinformatics resource for type 1 diabetes researchers. Available at http://tldbase.org/cgi-bin/welcome.cgi</mixed-citation><mixed-citation xml:lang="en">TIDBase: a bioinformatics resource for type 1 diabetes researchers. Available at http://tldbase.org/cgi-bin/welcome.cgi</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Ziegler AG, Schmid s, Huber D, Hummel M, Bonifacio E: Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies. JAMA 290:1721-1728,2003</mixed-citation><mixed-citation xml:lang="en">Ziegler AG, Schmid s, Huber D, Hummel M, Bonifacio E: Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies. JAMA 290:1721-1728,2003</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
