<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/2072-0351-6107</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-6107</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Эффективность и место сиофора (метформина) в терапии сахарного диабета 2 типа</article-title><trans-title-group xml:lang="en"><trans-title>Effektivnost' i mesto siofora (metformina) v terapii sakharnogo diabeta 2 tipa</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Балаболкин</surname><given-names>Михаил Иванович</given-names></name><name name-style="western" xml:lang="en"><surname>Balabolkin</surname><given-names>Mikhail Ivanovich</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Креминская</surname><given-names>Виктория Михайловна</given-names></name><name name-style="western" xml:lang="en"><surname>Kreminskaya</surname><given-names>Viktoriya Michailovna</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Эндокринологический научный центр РАМН, Москва</institution></aff><aff xml:lang="en"><institution>Endocrinology Research Centre, Moscow</institution></aff></aff-alternatives><aff xml:lang="ru" id="aff-2"><institution>Поликлиника № 221, Москва</institution></aff><pub-date pub-type="collection"><year>2001</year></pub-date><pub-date pub-type="epub"><day>15</day><month>03</month><year>2001</year></pub-date><volume>4</volume><issue>1</issue><issue-title>№1 (2001)</issue-title><fpage>41</fpage><lpage>46</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Балаболкин М.И., Креминская В.М., 2001</copyright-statement><copyright-year>2001</copyright-year><copyright-holder xml:lang="ru">Балаболкин М.И., Креминская В.М.</copyright-holder><copyright-holder xml:lang="en">Balabolkin M.I., Kreminskaya V.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/6107">https://www.dia-endojournals.ru/jour/article/view/6107</self-uri><abstract><p>Адекватность терапии СД остается самым актуальным вопросом, так как установлено, что гипергликемия является пусковым моментом многих патогенетических механизмов, способствующих развитию сосудистых осложнений. Строгой компенсацией диабета, т.е. поддержанием нормальной (или близко к нормальной) концентрации глюкозы в крови в течение длительного времени, удается задержать или отсрочить время появления поздних осложнений диабета. Для лечения СД, помимо диетотерапии, постоянного проведения комплекса физических упражнений, обучения больного принципам самоконтроля диабета, большое внимание отводится медикаментозной терапии, которая представлена несколькими группами таблетированных лекарственных препаратов. В настоящей статье мы остановимся на использовании бигуанидов, а более конкретно на применении метформина для лечения СД 2 типа.</p></abstract><kwd-group xml:lang="ru"><kwd>сиофор</kwd><kwd>метформин</kwd><kwd>лечение</kwd><kwd>сахарный диабет 2 типа</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bailey С J, Mynett К J, Page Т, Br J Pharmacol 1994, 112, 671-675.</mixed-citation><mixed-citation xml:lang="en">Bailey С J, Mynett К J, Page Т, Br J Pharmacol 1994, 112, 671-675.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Brown J В, Pedula К, Barzilay J et al., Diabetes Care, 1998, 21,1659-1663.</mixed-citation><mixed-citation xml:lang="en">Brown J В, Pedula К, Barzilay J et al., Diabetes Care, 1998, 21,1659-1663.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Dominguez L J, Davidoff a j, Srinivas P R. et al., Endocrinology, 1996, 137, 113-121.</mixed-citation><mixed-citation xml:lang="en">Dominguez L J, Davidoff a j, Srinivas P R. et al., Endocrinology, 1996, 137, 113-121.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Galuska D, Zierath J, Thome A et al., Diabete Metab, 1991, 17, suppl 1, 159-163.</mixed-citation><mixed-citation xml:lang="en">Galuska D, Zierath J, Thome A et al., Diabete Metab, 1991, 17, suppl 1, 159-163.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Hamann A, Benecke H, Greten H et al., Biochem Biophys Res Commun, 1993, 196, 382-387.</mixed-citation><mixed-citation xml:lang="en">Hamann A, Benecke H, Greten H et al., Biochem Biophys Res Commun, 1993, 196, 382-387.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Hundal H S, Ramlal T, Reyes R et al., Endocrinology, 1992, 131,11651173.</mixed-citation><mixed-citation xml:lang="en">Hundal H S, Ramlal T, Reyes R et al., Endocrinology, 1992, 131,11651173.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Kozka I J, Holman G D, Diabetes, 1993, 42, 1159-1 165.</mixed-citation><mixed-citation xml:lang="en">Kozka I J, Holman G D, Diabetes, 1993, 42, 1159-1 165.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Milburn J L, Ohneda M, Johnson J H, Unger R H, Diabetes Metab Rev, 1993,3,231-236.</mixed-citation><mixed-citation xml:lang="en">Milburn J L, Ohneda M, Johnson J H, Unger R H, Diabetes Metab Rev, 1993,3,231-236.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Misbin R I, Green L, Stadel В V. et al., N Engl J Med, 1998, 338, 265-266.</mixed-citation><mixed-citation xml:lang="en">Misbin R I, Green L, Stadel В V. et al., N Engl J Med, 1998, 338, 265-266.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Pentikainen P J, Neuvonen P J, Penttila A., Eur J Clin Pharmacol, 1979,16, 195-202.</mixed-citation><mixed-citation xml:lang="en">Pentikainen P J, Neuvonen P J, Penttila A., Eur J Clin Pharmacol, 1979,16, 195-202.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Ran J, Dominguez L, Sowers j R, Davidoff A J, Diabetes, 1999,48, 2059-2065.</mixed-citation><mixed-citation xml:lang="en">Ran J, Dominguez L, Sowers j R, Davidoff A J, Diabetes, 1999,48, 2059-2065.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Stith В J, Goalstone M L, Espinosa R, Endocrinology, 1996, 137, 29902999.</mixed-citation><mixed-citation xml:lang="en">Stith В J, Goalstone M L, Espinosa R, Endocrinology, 1996, 137, 29902999.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Signore A, Fiore V, Chianelli M, Procaccion E., Diab Res Cl Pract, 1996, 83-87.</mixed-citation><mixed-citation xml:lang="en">Signore A, Fiore V, Chianelli M, Procaccion E., Diab Res Cl Pract, 1996, 83-87.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Stumvoll M, Nurjhan N, Perriello G, N Engl J Med, 1995, 333, 550-554.</mixed-citation><mixed-citation xml:lang="en">Stumvoll M, Nurjhan N, Perriello G, N Engl J Med, 1995, 333, 550-554.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Sundaresan P, Lykos D, Daher A et al., Diabetes Care, 1997, 20, 692697.</mixed-citation><mixed-citation xml:lang="en">Sundaresan P, Lykos D, Daher A et al., Diabetes Care, 1997, 20, 692697.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Verma S., Bhanot S, McNeill J.H, JPET, 1 994, 271, 1 334-1 337.</mixed-citation><mixed-citation xml:lang="en">Verma S., Bhanot S, McNeill J.H, JPET, 1 994, 271, 1 334-1 337.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Verma S., McNeill J H„ Am. J Physiol, 1994, 266, H714-H719.</mixed-citation><mixed-citation xml:lang="en">Verma S., McNeill J H„ Am. J Physiol, 1994, 266, H714-H719.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Fiser Y., Thomas J., Rosen, et al., Endocrinology, 1995, 136, 41 2 420.</mixed-citation><mixed-citation xml:lang="en">Fiser Y., Thomas J., Rosen, et al., Endocrinology, 1995, 136, 41 2 420.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Marguie G., Atherosclerosis, 1978, 30, 165 170.</mixed-citation><mixed-citation xml:lang="en">Marguie G., Atherosclerosis, 1978, 30, 165 170.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Marguie G., Atherosclerosis, 1 983, 47, 7-14.</mixed-citation><mixed-citation xml:lang="en">Marguie G., Atherosclerosis, 1 983, 47, 7-14.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Sterne Y., Junien J.L., R.Soc. Med. Int. Congr. Sym. Ser, 1981, 48, 3 16</mixed-citation><mixed-citation xml:lang="en">Sterne Y., Junien J.L., R.Soc. Med. Int. Congr. Sym. Ser, 1981, 48, 3 16</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
