diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/2072-0351-6105diaendo-6105Research ArticleСтатьиArticlesИнсулинорезистентность в патогенезе сахарного диабета 2 типаInsulinorezistentnost' v patogeneze sakharnogo diabeta 2 tipaБалаболкинМихаил ИвановичBalabolkinMikhail Ivanovich-КлебановаЕлена МихайловнаKlebanovaElena Michailovna-Эндокринологический научный центр РАМН, МоскваEndocrinology Research Centre, Moscow20011503200141№1 (2001)2836Copyright © Балаболкин М.И., Клебанова Е.М., 20012001Балаболкин М.И., Клебанова Е.М.Balabolkin M.I., Klebanova E.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/6105

Инсулинорезистентность - снижение биологического ответа к одному или нескольким эффектам действия инсулина. Чаще инсулинорезистентность определяют как состояние, которое сопровождается сниженным поглощением глюкозы тканями организма под влиянием инсулина, т.е. резистентностью клеток различных органов и тканей к сахароснижающему действию инсулина. Инсулинорезистентность ответственна как за манифестацию СД 2 типа, так и за поддержание хронической гипергликемии, которая является пусковым механизмом патогенеза поздних сосудистых осложнений диабета, способствуя их быстрому прогрессированию и приводя к инвалидизации и высокой летальности. В настоящем обзоре подробно рассматриваются молекулярные механизмы формирования феномена инсулинорезистентности и возможные подходы (в том числе, медикаментозные) к ее устранению.

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The authors declare that there are no conflicts of interest present.