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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/2072-0351-6091</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-6091</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Влияние интенсивного контроля гликемии на развитие и прогрессирование диабетической нефропатии у больных сахарным диабетом 2 типа (по данным исследования ADVANCE)</article-title><trans-title-group xml:lang="en"><trans-title>Influence of intensive glycemic control on development and progression of diabetic nephropathy in patients with type 2 diabetes mellitus (based on results from ADVANCE study)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Клефортова</surname><given-names>Инна Игоревна</given-names></name><name name-style="western" xml:lang="en"><surname>Klefortova</surname><given-names>Inna Igorevna</given-names></name></name-alternatives><email xlink:type="simple">iklefort@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ Эндокринологический научный центр, Москва</institution></aff><aff xml:lang="en"><institution>Endocrinology Research Centre, Moscow</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>15</day><month>09</month><year>2012</year></pub-date><volume>15</volume><issue>3</issue><issue-title>№3 (2012)</issue-title><fpage>87</fpage><lpage>91</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Клефортова И.И., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Клефортова И.И.</copyright-holder><copyright-holder xml:lang="en">Klefortova I.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/6091">https://www.dia-endojournals.ru/jour/article/view/6091</self-uri><abstract><p>В статье прeдставлены данные о влиянии интенсивного контроля гликемии (базировавшегося на приеме Диабетона МВ)на развитие и прогрессирование диабетической нефропатии у больных сахарным диабетом 2 типа по данным исследованияADVANCE (Action in Diabetes and Vascular Disease: Preterax and DiamicroN Modified Release Controlled Evaluation), как изо-лированно, так и в комплексе с активным контролем артериального давления, посредством комбинации периндоприлаи индапамида.</p></abstract><trans-abstract xml:lang="en"><p>Current article presents data on effects of intensive glycemic control with Diabeton MR on development and progression of diabeticnephropathy in patients with type 2 diabetes mellitus (T2DM), accumulated from ADVANCE (Action in Diabetes and Vascular Disease:Preterax and DiamicroN Modified Release Controlled Evaluation study). Influence of intensive therapy with Diabeton MR wasassessed in that study separately and in conjunction with active antihypertensive treatment with perindopril and indapamide.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сахарный диабет</kwd><kwd>Диабетон МВ</kwd><kwd>диабетическая нефропатия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ADVANCE</kwd><kwd>diabetes mellitus</kwd><kwd>Diabeton MR</kwd><kwd>diabetic nephropathy</kwd><kwd>ADVANCE</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Coutinho M, Gerstein HC, Wang Y, Yusuf S. The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care. 1999; 22(2):233-240.</mixed-citation><mixed-citation xml:lang="en">Coutinho M, Gerstein HC, Wang Y, Yusuf S. 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