References

diaendo

Сахарный диабет

Diabetes mellitus

2072-03512072-0378

Endocrinology research centre

10.14341/2072-0351-6087

diaendo-6087

Research Article

Статьи

Articles

Возможности инкретиновой терапии у больных сахарным диабетом 2 типа и хронической болезнью почек

Inсretin-based therapy in patients with type 2 diabetes and chronic kidney disease

Шамхалова

Минара Шамхаловна

Shamkhalova

Minara Shamkhalovna

shamkhalova@mail.ru

Шестакова

Марина Владимировна

Shestakova

Marina Vladimirovna

ФГБУ Эндокринологический научный центр, МоскваEndocrinology Research Centre, Moscow

2012

15092012

153

№3 (2012)

5966

2012

Шамхалова М.Ш., Шестакова М.В.

Shamkhalova M.S., Shestakova M.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.dia-endojournals.ru/jour/article/view/6087

Реализация программы ренопротекции у больных сахарным диабетом (СД) основывается на концептуальной модели раз-вития и прогрессирования диабетического поражения почек, которая является результатом совокупного воздействия ме-таболических и гемодинамических факторов, модулируемых генетическими факторами. Компенсация углеводного обмена,играющая ключевую роль на ранних стадиях нефропатии, становится проблематичной на выраженных стадиях хрони-ческой болезни почек (ХБП). Рекомендации ADA (American Diabetes Association) и EASD (European Association for the Studyof Diabetes), оформленные в Консенсусе по лечению больных СД 2 типа (СД2) следует с большой осторожностью экстрапо-лировать на пациентов с ХБП. У препаратов инкретинового ряда складывается репутация перспективных и многообеща-ющих средств метаболического контроля в комплексной терапии сложнейшей группы пациентов с СД2 и ХБП. Очевиднанеобходимость масштабных, длительных исследований, включающих больных с различной выраженностью почечной па-тологии и соответствующих ей осложнений для оценки потенциальных возможностей нового тренда терапии диабета.

The program of renoprotection in patients with diabetes mellitus (DM) is based on a conceptual model of development and progressionof diabetic kidney disease, which is the result of combined impact of genetically modulated metabolic and hemodynamic factors. Compensationof carbohydrate metabolism, which is crucial at the clinical debut of nephropathy, becomes problematic at the late stages ofchronic kidney disease (CKD). ADA (American Diabetes Association) and EASD (European Association for the Study of Diabetes)recommendations formalized in a consensus on the treatment of patients with type 2 diabetes (T2D) should only be extrapolated topatients with CKD with great prudence. Incretin-based drugs gain reputation as promising and perspective therapy for metabolic controlin patients with type 2 DM and CKD. There is an obvious need for large-scale, long-term studies involving patients with various severityof renal disease and related complications to assess the potential of this new diabetes therapy trend.

сахарный диабетхроническая болезнь почекдиабетическая нефропатияинкретиновая терапия

diabetes mellituschronic kidney diseasediabetic nephropathyincretin-based therapy

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The authors declare that there are no conflicts of interest present.