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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/2072-0351-6060</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-6060</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Хронические раны и сахарный диабет: современная концепция и перспективы консервативного лечения</article-title><trans-title-group xml:lang="en"><trans-title>Chronic wounds and diabetes mellitus: modern concept and prospects for conservative treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Токмакова</surname><given-names>Алла Юрьевна</given-names></name><name name-style="western" xml:lang="en"><surname>Tokmakova</surname><given-names>Alla Yur'evna</given-names></name></name-alternatives><email xlink:type="simple">alla-tokmakova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Доронина</surname><given-names>Людмила Петровна</given-names></name><name name-style="western" xml:lang="en"><surname>Doronina</surname><given-names>Lyudmila Petrovna</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Страхова</surname><given-names>Галина Юрьевна</given-names></name><name name-style="western" xml:lang="en"><surname>Strakhova</surname><given-names>Galina Yur'evna</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГУ Эндокринологический научный центр, Москва</aff><aff xml:lang="en">Endocrinological Research Centre, Moscow</aff></aff-alternatives><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>15</day><month>12</month><year>2010</year></pub-date><volume>13</volume><issue>4</issue><issue-title>№4 (2010)</issue-title><fpage>63</fpage><lpage>68</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Токмакова А.Ю., Доронина Л.П., Страхова Г.Ю., 2010</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="ru">Токмакова А.Ю., Доронина Л.П., Страхова Г.Ю.</copyright-holder><copyright-holder xml:lang="en">Tokmakova A.Y., Doronina L.P., Strakhova G.Y.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/6060">https://www.dia-endojournals.ru/jour/article/view/6060</self-uri><abstract><p>Представлены современные тенденции в консервативном лечении хронических ран у больных сахарным диабетом, результаты собст-венных исследований по оценке эффективности различных методов разгрузки конечности у больных с нейропатической формой синдромадиабетической стопы и диабетической нефропатией, влияния коллагенсодержащих повязок на раневые факторы (матриксные метал-лопротеиназы 2 и 9 (ММП-2, ММП-9), коллагенолитическая активность) и скорость эпителизации дефектов.</p></abstract><trans-abstract xml:lang="en"><p>Current trends in conservative therapy of chronic wounds associated with diabetes mellitus are discussed along with results of original studies aimedto assess efficacy of different methods for unloading the affected leg in patients with the neuropathic form of diabetic foot syndrome and diabeticnephropathy. Effects of collagen-containing dressings on the wound-related factors (matrix metalloproteinases 2 and 9, collagenolytic activity) andwound epithelization rate are described.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сахарный диабет</kwd><kwd>хронические раны</kwd><kwd>синдром диабетической стопы</kwd><kwd>консервативное лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>diabetes mellitus</kwd><kwd>chronic wounds</kwd><kwd>diabetic foot syndrome</kwd><kwd>conservative treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Sen C., Gordillo G., Roy S., Krisner R. et al. Human skin wounds:A major and snowballing treat to public health and the economy // Wound Repair and Regeneration. - 2009. - Vol. 17, №6. - P. 763-771.</mixed-citation><mixed-citation xml:lang="en">Sen C., Gordillo G., Roy S., Krisner R. et al. Human skin wounds:A major and snowballing treat to public health and the economy // Wound Repair and Regeneration. - 2009. - Vol. 17, №6. - P. 763-771.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Singh N., Armstrong D.G., Lipsky B.A. Preventing foot ulcers in patients with diabetes // JAMA. - 2005. - 293. - P. 217-228.</mixed-citation><mixed-citation xml:lang="en">Singh N., Armstrong D.G., Lipsky B.A. Preventing foot ulcers in patients with diabetes // JAMA. - 2005. - 293. - P. 217-228.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Rogers L.C., Lavery L.A., Armstrong D.G. The right to bear legs - an amendment to healthcare: how preventing amputations can save billions for th US Halth-care System // J. Am. Podiatr. Med. Assoc. - 2008. - 98. - P. 166-168.</mixed-citation><mixed-citation xml:lang="en">Rogers L.C., Lavery L.A., Armstrong D.G. The right to bear legs - an amendment to healthcare: how preventing amputations can save billions for th US Halth-care System // J. Am. Podiatr. Med. Assoc. - 2008. - 98. - P. 166-168.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Gordois A., Scuffman P., Shearer A., Oglesby A., Tobian J.A. The health care cost of diabetic peripheral neuropathy in the US // Diabetes Care. - 2003. - 26. - P. 1790-1795.</mixed-citation><mixed-citation xml:lang="en">Gordois A., Scuffman P., Shearer A., Oglesby A., Tobian J.A. The health care cost of diabetic peripheral neuropathy in the US // Diabetes Care. - 2003. - 26. - P. 1790-1795.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Boulton A.J.M. The diabetic foot: a global view // Diabetes Metab. Res. Rev. - 2000. - 16. - Р. S2-S5.</mixed-citation><mixed-citation xml:lang="en">Boulton A.J.M. The diabetic foot: a global view // Diabetes Metab. Res. Rev. - 2000. - 16. - Р. S2-S5.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Международное соглашение по диабетической стопе. Составлено Международной группой по диабетической стопе. - М.: «Издатель- ство Берег». - 2000. - 96 с.</mixed-citation><mixed-citation xml:lang="en">Международное соглашение по диабетической стопе. Составлено Международной группой по диабетической стопе. - М.: «Издатель- ство Берег». - 2000. - 96 с.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Steed D.L., Attinger C., Collaizzi T., Crossland M. et al. Guidelines for the treatment of diabetic ulcers // Wound Repair and Regeneration. - 2006. - Vol. 14, № 6. - P. 680-692.</mixed-citation><mixed-citation xml:lang="en">Steed D.L., Attinger C., Collaizzi T., Crossland M. et al. Guidelines for the treatment of diabetic ulcers // Wound Repair and Regeneration. - 2006. - Vol. 14, № 6. - P. 680-692.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Алгоритмы специализированной медицинской помощи больным са- харным диабетом / Под ред. И.И. Дедова, М.В. Шестаковой. - М., 2009. - 101 с.</mixed-citation><mixed-citation xml:lang="en">Алгоритмы специализированной медицинской помощи больным са- харным диабетом / Под ред. И.И. Дедова, М.В. Шестаковой. - М., 2009. - 101 с.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Удовиченко О.В., Бублик Е.В., Максимова Н.В., Пряхина К.Ю. и соавт. Эффективность иммобилизирующих разгрузочных повязок Total Contact Cast: обзор зарубежных рандомизированных клинических исследований и собственные данные // Сахарный диабет. - 2010. - № 2. - С. 50-55.</mixed-citation><mixed-citation xml:lang="en">Удовиченко О.В., Бублик Е.В., Максимова Н.В., Пряхина К.Ю. и соавт. Эффективность иммобилизирующих разгрузочных повязок Total Contact Cast: обзор зарубежных рандомизированных клинических исследований и собственные данные // Сахарный диабет. - 2010. - № 2. - С. 50-55.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Cullen B., Smith R., Macculloch E., Silcock D., Morrison L. Mechanism of action of PROMOGRAN, a protease modulating matrix, for the treatment of diabetic foot ulcers // Wound Rep Reg. - 2002. - V. 10, №1. - P. 16-25.</mixed-citation><mixed-citation xml:lang="en">Cullen B., Smith R., Macculloch E., Silcock D., Morrison L. Mechanism of action of PROMOGRAN, a protease modulating matrix, for the treatment of diabetic foot ulcers // Wound Rep Reg. - 2002. - V. 10, №1. - P. 16-25.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Argenda L.C., Morykwas M.J. Vacuum-assisted closure: a new method for wound control and treatment: clinical experience // Ann. Plast. Surg. - 1997. - 38(6). - P. 563-576.</mixed-citation><mixed-citation xml:lang="en">Argenda L.C., Morykwas M.J. Vacuum-assisted closure: a new method for wound control and treatment: clinical experience // Ann. Plast. Surg. - 1997. - 38(6). - P. 563-576.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Fleischmann W., Becker U., Bischoff M., Hoekstra H. Vacuum sealing:indication, Technique and results // European. Jornal of Orthopaedic Surgery and Traumatilogy. - 1995. - 5. - Р. 37-40.</mixed-citation><mixed-citation xml:lang="en">Fleischmann W., Becker U., Bischoff M., Hoekstra H. Vacuum sealing:indication, Technique and results // European. Jornal of Orthopaedic Surgery and Traumatilogy. - 1995. - 5. - Р. 37-40.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">World Union of Wound Healing Societies' Initiative. Vacuum assisted closure: recommendations for use. A consensus document. - 2008. - 10 р.</mixed-citation><mixed-citation xml:lang="en">World Union of Wound Healing Societies' Initiative. Vacuum assisted closure: recommendations for use. A consensus document. - 2008. - 10 р.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Fife C.E., Carter M.J., Walker D. Why is so hard to do the right thing in wound care? // Wound Repaire anr Regeneratuon. - 2010. - Vol. 18, № 2. - P. 154-158.</mixed-citation><mixed-citation xml:lang="en">Fife C.E., Carter M.J., Walker D. Why is so hard to do the right thing in wound care? // Wound Repaire anr Regeneratuon. - 2010. - Vol. 18, № 2. - P. 154-158.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Patel N.P., Granick M.S. Wound education: American medical students are inadequately trained in wound care // Ann. Plast. Surg. - 2007. - 59. - P. 53-55.</mixed-citation><mixed-citation xml:lang="en">Patel N.P., Granick M.S. Wound education: American medical students are inadequately trained in wound care // Ann. Plast. Surg. - 2007. - 59. - P. 53-55.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Gottrup F. Trends in surgical wound healing // Scand. J. Surg. - 2008. - 97. - P. 53-56.</mixed-citation><mixed-citation xml:lang="en">Gottrup F. Trends in surgical wound healing // Scand. J. Surg. - 2008. - 97. - P. 53-56.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
