diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/2072-0351-5975diaendo-5975Research ArticleСтатьиArticlesАритмогенный эффект гипогликемииArrhythmogenic effects of hypoglycemiaЛаптевДмитрий НикитичLaptevDmitriy Nikitichlaptevdn@ya.ruШмушковичИрина АнатольевнаShmushkovichIrina Anatol'evnadia@endojournals.ruФГБУ Эндокринологический научный центр, МоскваEndocrinology Research Centre, Moscow201215032012151№1 (2012)2530Copyright © Лаптев Д.Н., Шмушкович И.А., 20122012Лаптев Д.Н., Шмушкович И.А.Laptev D.N., Shmushkovich I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/5975

У больных сахарным диабетом (СД), получающих инсулинотерапию, гипогликемия является достаточно частым явлением.Накопленные к настоящему времени клинические и экспериментальные доказательства свидетельствуют о том, что ги-погликемия может приводить к нарушению ритма и, возможно, связана с повышенным риском смертности у пациентовс СД. В обзоре рассматриваются наиболее вероятные механизмы развития аритмии на фоне гипогликемии, а также воз-можные патогенетические факторы. Приведены данные по частоте гипогликемии, а также связь эпизодов гипогликемиис повышенной сердечно-сосудистой и общей смертностью в клинических исследованиях ACCORD, ADVANCE, VADT.

Hypoglycemia is a frequent event in patients on insulin therapy. Current clinical and experimental evidence shows hypoglycemia tobe a cause of arrhythmia and, possibly, a link to increased mortality risk in patients with diabetes mellitus. This review addressesprobable mechanisms and pathogenic factors of arrhythmia development due to hypoglycemic events. We adduce data accumulatedon rates of hypoglycemia, as well as their correlation with cardiovascular and general mortality according to ACCORD, ADVANCEand VADT trials.

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The authors declare that there are no conflicts of interest present.