diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/2072-0351-5973diaendo-5973Research ArticleСтатьиArticlesПолиморфные маркеры генов IL2RA и IL2: популяционные различия в ассоциации с сахарным диабетомPolymorphic gene markers ILRA and IL2: population distinctions in association with diabetes mellitusКопыловаОльга ИгоревнаKopylovaOlga Igorevnaokopylova@gmail.comКураеваТамара ЛеонидовнаKuraevaTamara Leonidovnadia@endojournals.ruЛавриковаЕлена ЮрьевнаLavrikovaElena Yur'evnadia@endojournals.ruТитовичЕлена ВитальевнаTitovichElena Vital'evnadia@endojournals.ruНикитинАлексей ГеоргиевичNikitinAleksey Georgievichdia@endojournals.ruПетерковаВалентина АлександровнаPeterkovaValentina Alexandrovnadia@endojournals.ruНосиковВалерий ВячеславовичNosikovValery Vyacheslavovichdia@endojournals.ruДедовИван ИвановичDedovIvan Ivanovichdedov@endocrincentr.ruИнститут биохимической физики им. Н.М. Эмануэля РАН, МоскваInstitute of Biochemical physics, MoscowФГБУ Эндокринологический научный центр, МоскваEndocrinology Research Centre, Moscow201215032012151№1 (2012)1418Copyright © Копылова О.И., Кураева Т.Л., Лаврикова Е.Ю., Титович Е.В., Никитин А.Г., Петеркова В.А., Носиков В.В., Дедов И.И., 20122012Копылова О.И., Кураева Т.Л., Лаврикова Е.Ю., Титович Е.В., Никитин А.Г., Петеркова В.А., Носиков В.В., Дедов И.И.Kopylova O.I., Kuraeva T.L., Lavrikova E.Y., Titovich E.V., Nikitin A.G., Peterkova V.A., Nosikov V.V., Dedov I.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/5973Цель

Цель. Изучить ассоциацию с сахарным диабетом 1 типа (СД1) аллелей и генотипов полиморфных маркеров rs41295061и rs11594656 гена IL2RA, кодирующего α-цепь рецептора интерлейкина 2 и rs2069762 гена IL2, кодирующего интерлейкин-2.

Материалы и методы

Материалы и методы. В исследование включены группа больных СД1 (451 человек) и группа здоровых индивидов (306 человек) русского происхождения. Определение аллелей и генотипов полиморфных маркеров проводилось с помощью амплификации в реальном времени.

Результаты

Результаты. Сравнительный анализ распределения частот аллелей и генотипов полиморфных маркеров rs41295061и rs11594656 гена IL2RA и rs2069762 гена IL2 в группах больных СД1 и здоровых индивидов не выявил статистически значимых различий, что существенно отличает русских больных от больных из Западной Европы, где исследуемые полиморфные маркеры показывают существенную ассоциацию с СД1.

Заключение

Заключение. Сравнительный анализ распределения частот аллелей и генотипов полиморфных маркеров генов IL2-RAи IL2 выявил популяционные различия в ассоциации с СД1 этих маркеров у русских больных и больных из Западной Европы.

AIMS

AIMS: In order to study type 1 diabetes mellitus associations, we conducted a comparative analysis of allele and genotype frequencydistribution of polymorphic markers rs41295061 and rs11594656 of IL2RA gene, which encodes α-chain of interleukin-2 receptor, - and rs2069762, a marker of IL2, gene, encoding interleukin-2.

MATERIALS AND METHODS

MATERIALS AND METHODS: Experimental group included 451 patients with type 1 diabetes mellitus (DM); control group consistedof 306 healthy subjects (both groups were represented by ethnic Russians). Alleles and polymorphic markers were identified byreal-time amplification method.

RESULTS

RESULTS: A comparative analysis of patients with type 1 DM and healthy control group did not show statistically significant differencesfrom the viewpoint of allele and genotype frequency distribution of polymorphic markers rs41295061, rs11594656 and rs2069762. This makes Russian patients considerably different from European ones where markers in question show substantialassociation with type 1 DM.

CONCLUSIONS

CONCLUSIONS: A comparative analysis of allele and genotype frequency distribution of IL2-RA and IL2 genes polymorphic markersshowed population differences in association of these markers in Russian and European patients.

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The authors declare that there are no conflicts of interest present.