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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/2072-0351-5952</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-5952</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Исследование ADVANCE: влияние Нолипрела - фиксированной комбинации ингибитора АПФ (Периндоприла) и диуретика (Индапамида) - на развитие сердечно-сосудистых осложнений у пациентов с сахарным диабетом 2 типа</article-title><trans-title-group xml:lang="en"><trans-title>Issledovanie ADVANCE: vliyanie Noliprela - fiksirovannoy kombinatsii ingibitora APF (Perindoprila) i diuretika (Indapamida) - na razvitie serdechno-sosudistykh oslozhneniy u patsientov s sakharnym diabetom 2 tipa</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шестакова</surname><given-names>Марина Владимировна</given-names></name><name name-style="western" xml:lang="en"><surname>Shestakova</surname><given-names>Marina Vladimirovna</given-names></name></name-alternatives><email xlink:type="simple">nephro@endocrincentr.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Александров</surname><given-names>Андрей Алексеевич</given-names></name><name name-style="western" xml:lang="en"><surname>Aleksandrov</surname><given-names>Andrey Alexeevich</given-names></name></name-alternatives><email xlink:type="simple">endocar@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Галицина</surname><given-names>Наталья Александровна</given-names></name><name name-style="western" xml:lang="en"><surname>Galitsyna</surname><given-names>Natalya</given-names></name></name-alternatives><email xlink:type="simple">info@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГУ Эндокринологический научный центр Росмедтехнологий, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Endocrinology Research Centre, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>15</day><month>03</month><year>2008</year></pub-date><volume>11</volume><issue>1</issue><issue-title>№1 (2008)</issue-title><fpage>81</fpage><lpage>84</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шестакова М.В., Александров А.А., Галицина Н.А., 2008</copyright-statement><copyright-year>2008</copyright-year><copyright-holder xml:lang="ru">Шестакова М.В., Александров А.А., Галицина Н.А.</copyright-holder><copyright-holder xml:lang="en">Shestakova M.V., Aleksandrov A.A., Galitsyna N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/5952">https://www.dia-endojournals.ru/jour/article/view/5952</self-uri><abstract><p>В сентябре 2007 г. в Вене на очередном Европейском конгрессе кардиологов впервые были публично представлены результаты исследования ADVANCE, посвященного предотвращению сердечно-сосудистых осложнений у больных сахарным диабетом 2 типа (СД 2). Решение этой проблемы ? одна из важнейших задач современной медицины. Эпидемия сахарного диабета, захлестывающая сегодняшний мир, ведет к ранней инвалидизации и смертности миллионов таких больных. Как правило, трагические исходы обусловлены сердечно-сосудистыми осложнениями сахарного диабета 2 типа (СД 2), в первую очередь ишемической болезнью сердца.</p></abstract><kwd-group xml:lang="ru"><kwd>ADVANCE</kwd><kwd>сахарный диабет 2 типа</kwd><kwd>сердечно-сосудистые осложнения</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">ADVANCE trial: presented also at the Hot-line session at the European Congress of Cardiology in Vienna 2007, September 2. http://www.advance-trial.com</mixed-citation><mixed-citation xml:lang="en">ADVANCE trial: presented also at the Hot-line session at the European Congress of Cardiology in Vienna 2007, September 2. http://www.advance-trial.com</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Patel A; ADVANCE Collaborative Group, MacMahon S, Chalmers J et al. 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