diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/2072-0351-5865diaendo-5865Research ArticleСтатьиArticlesПрименение убихинона (коэнзима Q) в комплексной терапии сахарного диабета и его сосудистых осложненийPrimenenie ubikhinona (koenzima Q) v kompleksnoy terapii sakharnogo diabeta i ego sosudistykh oslozhneniyБалаболкинМихаил ИвановичBalabolkinMikhail Ivanovich-КлебановаЕлена МихайловнаKlebanovaElena Michailovna-КреминскаяВиктория МихайловнаKreminskayaViktoriya Michailovna-ММА им. И.М.Сеченова, Москва200715122007104№4 (2007)3742Copyright © Балаболкин М.И., Клебанова Е.М., Креминская В.М., 20072007Балаболкин М.И., Клебанова Е.М., Креминская В.М.Balabolkin M.I., Klebanova E.M., Kreminskaya V.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/5865

Изучение роли и значимости свободных радикалов в нарушении метаболизма позволило установить, что свободные радикалы кислорода участвуют в патогенезе почти 100 заболеваний, включая сахарный диабет и его сосудистые осложнения. Установлено, что при этих заболеваниях в мембранах и цитозоле клеток различных тканей выявляется повышенное содержание как свободных радикалов, так и продуктов их свободнорадикального окисления (альдегиды, кетоны, эпоксиды, гидроперекиси, диеновые и триеновые конъюгаты). Исследованиями подтверждено, что источниками образования свободных радикалов кислорода являются шесть путей метаболизма глюкозы.

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The authors declare that there are no conflicts of interest present.