diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/2072-0351-5809diaendo-5809Research ArticleСтатьиArticlesИсследование эффекта и действия лираглутида при сахарном диабете (LEADTM) Expert Rev. Endocrinol. Metab. 4(2), 119-129 (2009)Issledovanie effekta i deystviya liraglutida pri sakharnom diabete (LEADTM) Expert Rev. Endocrinol. Metab. 4(2), 119-129 (2009)МэдсбэдСтенMedsbedSten-Университетская больница Хвидовре, Хвидовре, Дания200915122009125№5 (2009)1120Copyright © Мэдсбэд С., 20092009Мэдсбэд С.Medsbed S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/5809

Лираглутид ? это первый аналог человеческого глюкагоноподобного пептида-1, основанный на структуре нативного глюкагоноподобного пептида-1. Фармакокинетические свойства препарата позволяют применять его один раз в день. В исследованиях II фазы и программе?Исследование эффекта и действия лираглутида при диабете (LEADTM)? III фазы, лираглутид стойко снижал уровень гликированного гемоглобина A1c. Лираглутид также улучшал функцию b-клеток, способствовал снижению массы тела и систолического артериального давления, а также позитивно влиял на некоторые маркеры сердечно-сосудистого риска. Лираглутид обладает хорошей переносимостью; наиболее распространенным побочным эффектом является транзиторная тошнота.В данной статье приведен обзор исследований II фазы и программы LEADTM III фазы.

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The authors declare that there are no conflicts of interest present.