diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/2072-0351-5785diaendo-5785Research ArticleСтатьиArticlesPPARy - представитель семейства ядерных стероидных рецепторовPPARy - predstavitel' semeystva yadernykh steroidnykh retseptorovКононенкоИрина ВладимировнаKononenkoIrina Vladimirovna-СмирноваОльга МихайловнаSmirnovaOlga Mikhailovna-ГУ Эндокринологический научный центр РАМН, МоскваEndocrinology Research Centre, Moscow20051506200582№2 (2005)7477Copyright © Кононенко И.В., Смирнова О.М., 20052005Кононенко И.В., Смирнова О.М.Kononenko I.V., Smirnova O.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/5785

PPARy ? peroxisome proliferator-activated receptor относится к семейству ядерных стероидных рецепторов, куда также входят рецепторы прогестерона, эстрогенов, витамина D, рецепторы глюкокортикоидов и минералкортикоидов, андрогенов, ретиноевой кислоты, тиреоидных гормонов. Лигандами ядерных стероидных рецепторов являются стероиды, ретиноиды, витамин D, тиреоидный гормон, простаноиды и холестероловые метаболиты (оксистеролы и желчные кислоты). Их комбинированные эффекты огромны, они влияют на каждый фундаментальный биологический процесс, от развития и гомеостаза до клеточной пролиферации и дифференцировки.

PPARyрецепторысахарный диабетReferencesМолекулярная эндокринология. М., «Медицина». 2 0 0 3 . Под ред. Брюса Д. Вайнтрауба. Глава 5. Стр. 4 0 - 5 4 .Молекулярная эндокринология. М., «Медицина». 2 0 0 3 . Под ред. Брюса Д. Вайнтрауба. Глава 5. Стр. 4 0 - 5 4 .Молекулярная эндокринология. M., «Медицина». 2 0 0 3 . Под ред. Брюса Д. Вайнтрауба. Глава 14. Стр. 191-208.Молекулярная эндокринология. M., «Медицина». 2 0 0 3 . Под ред. Брюса Д. Вайнтрауба. Глава 14. Стр. 191-208.Физиология обмена веществ и эндокринной системы. M., «Мир», 1989. Дж.Теп- пермен, Х.Теппермен. Под ред. к.м.н. Я.И. Ажипы. Глава 2.Физиология обмена веществ и эндокринной системы. M., «Мир», 1989. Дж.Теп- пермен, Х.Теппермен. Под ред. к.м.н. Я.И. Ажипы. Глава 2.Beato M. Gene regulation by steroid hormones. / / Cell. - 1989 - V.56. - P. 335-344.Beato M. Gene regulation by steroid hormones. / / Cell. - 1989 - V.56. - P. 335-344.Djouadi F., Weinheimer C.J., Saffitz J.E. A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferators-activated receptor alpha-deficient mice. / / J Clin Invest. - 1998 - V.l 02(6). - P. 1 0 8 2 - 1 0 9 1 .Djouadi F., Weinheimer C.J., Saffitz J.E. A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferators-activated receptor alpha-deficient mice. / / J Clin Invest. - 1998 - V.l 02(6). - P. 1 0 8 2 - 1 0 9 1 .Forman B.M., Samuels H.H. Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model. / / Mol. Endocrinol. - 1990 - V.4. - P.l 293-1301.Forman B.M., Samuels H.H. Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model. / / Mol. Endocrinol. - 1990 - V.4. - P.l 293-1301.Gurnell M. PPAR gamma and metabolism: insights from the study of human G variants. / / Clin Endocrinol. - 2003 - V.59(3) - 9.267-277.Gurnell M. PPAR gamma and metabolism: insights from the study of human G variants. / / Clin Endocrinol. - 2003 - V.59(3) - 9.267-277.Heaney A. PPAR-gamma ligands: Novel therapy. 12-th International Congress of Endocrinology. Lisbon. 2 0 0 4 . Symposium Abstract SY 25.Heaney A. PPAR-gamma ligands: Novel therapy. 12-th International Congress of Endocrinology. Lisbon. 2 0 0 4 . Symposium Abstract SY 25.Issemann I., Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisor proliferators. / / Nature - 1990 - V.347 - P.645-650.Issemann I., Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisor proliferators. / / Nature - 1990 - V.347 - P.645-650.Ignatieva E.V. The lipid metabolism transcription regulatory regions database (LMTRRD): transcription reguiatorion of lipid metabolism genes (eignat@bionet.nsc.ru) / / http://www.bionet.nsc.ru/bgrs/thesis/10/index.html.Ignatieva E.V. The lipid metabolism transcription regulatory regions database (LMTRRD): transcription reguiatorion of lipid metabolism genes (eignat@bionet.nsc.ru) / / http://www.bionet.nsc.ru/bgrs/thesis/10/index.html.Lemberger Т., Staels В., Saladin R. Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids. / / J Biol Chem. - 1994 - Oct 7; 269 (40). - P. 2 4 5 2 7 - 3 0 .Lemberger Т., Staels В., Saladin R. Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids. / / J Biol Chem. - 1994 - Oct 7; 269 (40). - P. 2 4 5 2 7 - 3 0 .Lemon B.D, Freedman L.P. Cofactors and nuclear receptors. / / Current Opinion in genetics and development. - 1 9 8 9 . - V.9 - P.499-504.Lemon B.D, Freedman L.P. Cofactors and nuclear receptors. / / Current Opinion in genetics and development. - 1 9 8 9 . - V.9 - P.499-504.Loviscach M., Henry R.R. Clinical Significance of peroxisome proliferator-acrivated receptors in health and disease. / / Medscape Diabetes and Endocrinology. - 1999 - 1 (2).Loviscach M., Henry R.R. Clinical Significance of peroxisome proliferator-acrivated receptors in health and disease. / / Medscape Diabetes and Endocrinology. - 1999 - 1 (2).Picard D., Salser S.J., Yamamoto K.R. A movable and regulatable inactivation function within the steroid binding domain of the glucocorticoid receptor. / / Cell - 1988 - V . 5 4 . OP. 1073-1080.Picard D., Salser S.J., Yamamoto K.R. A movable and regulatable inactivation function within the steroid binding domain of the glucocorticoid receptor. / / Cell - 1988 - V . 5 4 . OP. 1073-1080.Rosen E.D., Spiegelman B.M. Molecular regulation of adipogenesis. / / Ann. Rev. Dev. Biol. - 2 0 0 0 - V. 16. - P. 145-171.Rosen E.D., Spiegelman B.M. Molecular regulation of adipogenesis. / / Ann. Rev. Dev. Biol. - 2 0 0 0 - V. 16. - P. 145-171.6. Santen R.J., Manni A., Harvey H. Endocrine treatment of breast cancer in women. / / EndocrRev. - 1 9 9 0 - V . 1 1 - P . 2 2 1 - 2 6 5.6. Santen R.J., Manni A., Harvey H. Endocrine treatment of breast cancer in women. / / EndocrRev. - 1 9 9 0 - V . 1 1 - P . 2 2 1 - 2 6 5.Stalla G.K. Retinoic acid derivatives for the treatment of Cushing's disease. / / 12-th International Congress of Endocrinology. Lisbon. 2004. Symposium abstract. SY26.Stalla G.K. Retinoic acid derivatives for the treatment of Cushing's disease. / / 12-th International Congress of Endocrinology. Lisbon. 2004. Symposium abstract. SY26.8. Staels В., Auwerx J.Regulation of apo A-l gene expression by fibrates. / / Atherosclerosis. - 1998 - V.l 3 7 (suppl). - S. 19-23.8. Staels В., Auwerx J.Regulation of apo A-l gene expression by fibrates. / / Atherosclerosis. - 1998 - V.l 3 7 (suppl). - S. 19-23.Staels В., Koenig W., HabibA., et al. Activation of human aortic smooth-muscle cell is inhibited by PPAR alfa but not by PPAR gamma activators. / / Nature. - 1998 - V.393 (6687) - P.790-793.Staels В., Koenig W., HabibA., et al. Activation of human aortic smooth-muscle cell is inhibited by PPAR alfa but not by PPAR gamma activators. / / Nature. - 1998 - V.393 (6687) - P.790-793.Su J.L., Simmons C.J., Wisely b. Monitoring of PPAR alfa protein expression in human tissue by the use of PPAR alfa-specific MAbs. / / Hybridoma. - 1998 - V . 1 7 ( l ) - P . 4 7 - 5 3 .Su J.L., Simmons C.J., Wisely b. Monitoring of PPAR alfa protein expression in human tissue by the use of PPAR alfa-specific MAbs. / / Hybridoma. - 1998 - V . 1 7 ( l ) - P . 4 7 - 5 3 .Tomaru Т., Satoh Т., Ishizuka T. Isolation of a novel transcriptional cofactor that binds the DNA-binding domain of peroxisome proliferators-activated receptor g. / / 12-th International Congress of Endocrinology. Lisbon. 2 0 0 4 . Oral Sessioin.Tomaru Т., Satoh Т., Ishizuka T. Isolation of a novel transcriptional cofactor that binds the DNA-binding domain of peroxisome proliferators-activated receptor g. / / 12-th International Congress of Endocrinology. Lisbon. 2 0 0 4 . Oral Sessioin.Wang Y. et al. Peroxisom-proliferated receptor g activates fat metabolism to prevent obesity. / / Cell. - 2003 - V.l 13 - P. 159-170.Wang Y. et al. Peroxisom-proliferated receptor g activates fat metabolism to prevent obesity. / / Cell. - 2003 - V.l 13 - P. 159-170.Zhzng X., Toung H. PPAR and immune system - what do we know? / / Internation immunopharmacology. - 2002 - V.2. - p. 1029-1044.Zhzng X., Toung H. PPAR and immune system - what do we know? / / Internation immunopharmacology. - 2002 - V.2. - p. 1029-1044.

The authors declare that there are no conflicts of interest present.