diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/2072-0351-5784diaendo-5784Research ArticleСтатьиArticlesРоль синтетического лиганда PPARy-росиглитазона в патогенетическом лечении сахарного диабета 2 типаRol' sinteticheskogo liganda PPARy-rosiglitazona v patogeneticheskom lechenii sakharnogo diabeta 2 tipaКононенкоИрина ВладимировнаKononenkoIrina Vladimirovna-СмирноваОльга МихайловнаSmirnovaOlga Mikhailovna-ГУ Эндокринологический научный центр РАМН, МоскваEndocrinology Research Centre, Moscow20051506200582№2 (2005)6673Copyright © Кононенко И.В., Смирнова О.М., 20052005Кононенко И.В., Смирнова О.М.Kononenko I.V., Smirnova O.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/5784

Росиглитазон (Авандия) обеспечивает значительное снижение глюкозы плазмы натощак, HbAlc и уровня постпрандиальной гликемии. Достигнутая компенсация углеводного обмена сохраняется длительное время. Росиглитазон эффективен в качестве монотерапии и в комбинации с метформином, производными сульфонилмочевины и с инсулином, как при однократном, так и при двукратном приеме вне зависимости от приема пищи. Росиглитазон эффективен как у больных СД 2 типа, имеющих ожирение, так и без ожирения. Росиглитазон улучшает функцию бета-клеток и тем самым способен замедлять прогрессирование заболевания. Воздействуя практически на все компоненты метаболического синдрома, росиглитазон способен снижать риск развития и прогрессирования сердечно-сосудистых заболеваний.

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