diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/2072-0351-5747diaendo-5747Research ArticleСтатьиArticlesСТГ и ИФР- 1 при сахарном диабете: роль в патогенезе микрососудистых осложненийSTG i IFR-1 pri sakharnom diabete: rol' v patogeneze mikrososudistykh oslozhneniyВолеводзНаталья НикитичнаVolevodzNatalya Nikitichna-ТощевиковаА КToshchevikovaA K-Эндокринологический научный центр РАМН, МоскваEndocrinology Research Centre, Moscow20001503200031№1 (2000)5359Copyright © Волеводз Н.Н., Тощевикова А.К., 20002000Волеводз Н.Н., Тощевикова А.К.Volevodz N.N., Toshchevikova A.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/5747

Патогенез сахарного диабета (СД) и его сосудистых осложнений носит многофакторный характер. Одним из его звеньев являются изменения секреции соматотропного гормона (СТГ) и инсулиноподобного фактора роста 1 (ИФР-1). Повышение секреции СТГ при СД 1 и СД 2 типа в настоящее время является общепризнанным фактом; повышен как базальный, так и среднесуточный его уровень. Несмотря на высокую концентрацию СТГ, уровень ИФР-1 при СД снижен. ИФРСБ-1 служит для доставки ИФР-1 в ткани, где может модулировать биодоступность ИФР-1. При СД отмечается повышенный уровень ИФРСБ-1. Система "СТГ-ИФР-1" может быть частью патогенеза различных сосудистых осложнений СД, таких как диабетическая нейропатия, диабетическая ретинопатия, диабетическая нефропатия. Терапия ИФР-1 пациентов с СД ранее всего стала применяться в случаях инсулинорезистентности, в том числе генетических форм рецепторной и пострецепторной инсулинорезистентности. Влияние терапии рекомбинантным ИФР-1 на развитие поздних осложнений СД наименее изучено. Для того чтобы установить влияние терапии ИФР-1 на развитие поздних осложнений СД и тканевые концентрации ИФР-1, определить оптимальные дозы ИФР-1, необходимы долговременные плацебо-контролируемые исследования.

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The authors declare that there are no conflicts of interest present.