<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/2072-0351-5715</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-5715</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Риск онкологических заболеваний у больных сахарным диабетом</article-title><trans-title-group xml:lang="en"><trans-title>Risk of oncological diseases in patients with diabetes mellitus</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Галстян</surname><given-names>Гагик Радикович</given-names></name><name name-style="western" xml:lang="en"><surname>Galstyan</surname><given-names>Gagik Radikovich</given-names></name></name-alternatives><email xlink:type="simple">foot@endocrincentr.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГУ Эндокринологический научный центр, Москва</institution></aff><aff xml:lang="en"><institution>Endocrinology Research Centre, Moscow</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>15</day><month>12</month><year>2009</year></pub-date><volume>12</volume><issue>4</issue><issue-title>№4 (2009)</issue-title><fpage>105</fpage><lpage>107</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Галстян Г.Р., 2009</copyright-statement><copyright-year>2009</copyright-year><copyright-holder xml:lang="ru">Галстян Г.Р.</copyright-holder><copyright-holder xml:lang="en">Galstyan G.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/5715">https://www.dia-endojournals.ru/jour/article/view/5715</self-uri><abstract><p>В сентябрьском номере журнала Европейской ассоциации по изучению сахарного диабета (EASD) ?Diabetologia? была опубликована серия из четырех статей. В них анализировались эпидемиологические данные регистров Германии, Швеции, Шотландии и Великобритании о применении инсулина гларгин и риске развития рака. Практически одновременно на сайте EASD (www.easd.com) было опубликовано заявление о позиции EASD по этому вопросу, за которым вскоре последовали аналогичные заявления Американской диабетической ассоциации (ADA), Американской ассоциации клинических эндокринологов (AACE), международного общества эндокринологов (ISE) и Международной диабетической федерации (IDF).</p></abstract><kwd-group xml:lang="ru"><kwd>сахарный диабет</kwd><kwd>онкологические заболевания</kwd><kwd>инсулин</kwd><kwd>гларгин</kwd><kwd>метформин</kwd><kwd>производные сулфонилмочевины</kwd></kwd-group><kwd-group xml:lang="en"><kwd>diabetes mellitus</kwd><kwd>oncological diseases</kwd><kwd>insulin</kwd><kwd>glargin</kwd><kwd>metformin</kwd><kwd>sulfonylurea drugs</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Jonasson J.M., Ljung R., Talbдck M., Haglund B., Gudbjцrnsdтttir S., Steineck G. Insulin glargine use and short-term incidence of malignancies-a populationbased follow-up study in Sweden //Diabetologia. - 2009. - Sep.; 52(9). - 1745-1754.</mixed-citation><mixed-citation xml:lang="en">Jonasson J.M., Ljung R., Talbдck M., Haglund B., Gudbjцrnsdтttir S., Steineck G. Insulin glargine use and short-term incidence of malignancies-a populationbased follow-up study in Sweden //Diabetologia. - 2009. - Sep.; 52(9). - 1745-1754.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Colhoun H.M.; SDRN Epidemiology Group. Use of insulin glargine and cancer incidence in Scotland: a study from the Scottish Diabetes Research Network Epidemiology Group //Diabetologia. - 2009. - Sep.; 52(9). - 1755-1765.</mixed-citation><mixed-citation xml:lang="en">Colhoun H.M.; SDRN Epidemiology Group. Use of insulin glargine and cancer incidence in Scotland: a study from the Scottish Diabetes Research Network Epidemiology Group //Diabetologia. - 2009. - Sep.; 52(9). - 1755-1765.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Currie C.J., Poole C.D., Gale E.A. The influence of glucose-lowering therapies on cancer risk in type 2 diabetes //Diabetologia. - 2009. - Sep.; 52(9). - 1766-1777.</mixed-citation><mixed-citation xml:lang="en">Currie C.J., Poole C.D., Gale E.A. The influence of glucose-lowering therapies on cancer risk in type 2 diabetes //Diabetologia. - 2009. - Sep.; 52(9). - 1766-1777.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Couglin S.S. et al (2004). Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults //Am. J. Epidemiol. - 159. - 1160-1167.</mixed-citation><mixed-citation xml:lang="en">Couglin S.S. et al (2004). Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults //Am. J. Epidemiol. - 159. - 1160-1167.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Larsson S.C. et al (2005). Diabetes mellitus and risk of breast cancer: a metaanalysis //Int. J. Cancer. - 97. - 1679-1686.</mixed-citation><mixed-citation xml:lang="en">Larsson S.C. et al (2005). Diabetes mellitus and risk of breast cancer: a metaanalysis //Int. J. Cancer. - 97. - 1679-1686.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Huxley R. et al (2005). Type 2 diabetes and pancreatic cancer: a meta-analysis of 36 studies //Br. J. Cancer. - 92. - 2076-2083.</mixed-citation><mixed-citation xml:lang="en">Huxley R. et al (2005). Type 2 diabetes and pancreatic cancer: a meta-analysis of 36 studies //Br. J. Cancer. - 92. - 2076-2083.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Larsson S.C. et al (2007). Diabetes mellitus and risk of breast cancer //J. Int. Cancer. - 121. - 856-862.</mixed-citation><mixed-citation xml:lang="en">Larsson S.C. et al (2007). Diabetes mellitus and risk of breast cancer //J. Int. Cancer. - 121. - 856-862.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Zendehdel K. et al (2003). Cancer incindence in Type 1 diabetic patients in Sweden //J. Natl. Cancer. Inst. - 95. - 1797-1800.</mixed-citation><mixed-citation xml:lang="en">Zendehdel K. et al (2003). Cancer incindence in Type 1 diabetic patients in Sweden //J. Natl. Cancer. Inst. - 95. - 1797-1800.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Fraylink T.M. Colhoum H., Florez J.C. (2008). A genetic link between type 2 diabetes and prostate cancer //Diabetologia. - 51. - 1757-1760.</mixed-citation><mixed-citation xml:lang="en">Fraylink T.M. Colhoum H., Florez J.C. (2008). A genetic link between type 2 diabetes and prostate cancer //Diabetologia. - 51. - 1757-1760.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Smith U., Gale E.A. Does diabetes therapy influence the risk of cancer? //Diabetologia. - 2009. - Sep.; 52(9). - 1699-1708.</mixed-citation><mixed-citation xml:lang="en">Smith U., Gale E.A. Does diabetes therapy influence the risk of cancer? //Diabetologia. - 2009. - Sep.; 52(9). - 1699-1708.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Garg S.K., Hirsch I.B., Skyler J.S. Insulin glargine and cancer - an unsubstantiated allegation //Diabetes Technolnology &amp;amp; Therapeutics. - 2009. - Aug.; 11(8). - 473-476.</mixed-citation><mixed-citation xml:lang="en">Garg S.K., Hirsch I.B., Skyler J.S. Insulin glargine and cancer - an unsubstantiated allegation //Diabetes Technolnology &amp;amp; Therapeutics. - 2009. - Aug.; 11(8). - 473-476.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Pocock S.J., Smeeth L. Insulin glargine and malignancy: an unwarranted alarm //Lancet. - 2009. - Aug. 15; 374(9689). - 511-3.</mixed-citation><mixed-citation xml:lang="en">Pocock S.J., Smeeth L. Insulin glargine and malignancy: an unwarranted alarm //Lancet. - 2009. - Aug. 15; 374(9689). - 511-3.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Owens D.R., Rosenstock J., Bolli G.B. Insulin glargine and cancer: cause and effect unproven //Practical Diabetes International. - 2009. - Sep.; 26(7). - 256-257.</mixed-citation><mixed-citation xml:lang="en">Owens D.R., Rosenstock J., Bolli G.B. Insulin glargine and cancer: cause and effect unproven //Practical Diabetes International. - 2009. - Sep.; 26(7). - 256-257.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Nagel J.M., Mansmann U., Wegscheider K., Rцhmel J. Insulin resistance and increased risk for malignant neoplasms: confounding of the data on insulin glargine //Diabetologia. - 2009. - Sep. 24. [Epub. ahead. of print].</mixed-citation><mixed-citation xml:lang="en">Nagel J.M., Mansmann U., Wegscheider K., Rцhmel J. Insulin resistance and increased risk for malignant neoplasms: confounding of the data on insulin glargine //Diabetologia. - 2009. - Sep. 24. [Epub. ahead. of print].</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Rosenstock J., Fonseca V., McGill J.B., Riddle M., Hallй J.P., Hramiak I., Johnston P., Davis M. Similar risk of malignancy with insulin glargine and neutral protamine Hagedorn (NPH) insulin in patients with type 2 diabetes: findings from a 5 year randomised, open-label study //Diabetologia. - 2009. - Sep.; 52(9). - 1971-1973.</mixed-citation><mixed-citation xml:lang="en">Rosenstock J., Fonseca V., McGill J.B., Riddle M., Hallй J.P., Hramiak I., Johnston P., Davis M. Similar risk of malignancy with insulin glargine and neutral protamine Hagedorn (NPH) insulin in patients with type 2 diabetes: findings from a 5 year randomised, open-label study //Diabetologia. - 2009. - Sep.; 52(9). - 1971-1973.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Home P.D., Lagarenne P. Combined randomised controlled trial experience of malignancies in studies using insulin glargine //Diabetologia. - 2009. - Sep. 15. [Epub. ahead. of print].</mixed-citation><mixed-citation xml:lang="en">Home P.D., Lagarenne P. Combined randomised controlled trial experience of malignancies in studies using insulin glargine //Diabetologia. - 2009. - Sep. 15. [Epub. ahead. of print].</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Origin Trial Investigators, Gerstein H., Yusuf S., Riddle M.C., Ryden L., Bosch J. Rationale, design, and baseline characteristics for a large international trial of cardiovascular disease prevention in people with dysglycemia: the ORIGIN Trial (Outcome Reduction with an Initial Glargine Intervention) //American Heart Journal. - 2008. - Jan.; 155(1). - 26-32.</mixed-citation><mixed-citation xml:lang="en">Origin Trial Investigators, Gerstein H., Yusuf S., Riddle M.C., Ryden L., Bosch J. Rationale, design, and baseline characteristics for a large international trial of cardiovascular disease prevention in people with dysglycemia: the ORIGIN Trial (Outcome Reduction with an Initial Glargine Intervention) //American Heart Journal. - 2008. - Jan.; 155(1). - 26-32.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Hemkens L.G., Grouven U., Bender R., Gьnster C., Gutschmidt S., Selke G.W., Sawicki P.T. Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study // Diabetologia. - 2009. - Sep.; 52(9). - 1732-1744.</mixed-citation><mixed-citation xml:lang="en">Hemkens L.G., Grouven U., Bender R., Gьnster C., Gutschmidt S., Selke G.W., Sawicki P.T. Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study // Diabetologia. - 2009. - Sep.; 52(9). - 1732-1744.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
