diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/2072-0351-5695diaendo-5695Research ArticleСтатьиArticlesБесплодный брак у пациентов с сахарным диабетомInfertile marriage in patients with diabetes mellitusВитязеваИрина ИвановнаVityazevaIrina IvanovnaE-mail: eko@endocrincentr.ruБоголюбовСергей ВладимировичBogolyubovSergey Vladimirovich-ИловайскаяИрена АдольфовнаIlovayskayaIrena Adol'fovna-МакароваНаталия ПетровнаMakarovaNataliya Petrovna-ЛьвоваАлеся ГеннадьевнаL'vovaAlesya Gennad'evna-ФГУ Эндокринологический научный центр, МоскваEndocrinology Research Centre, Moscow200915122009124№4 (2009)69Copyright © Витязева И.И., Боголюбов С.В., Иловайская И.А., Макарова Н.П., Львова А.Г., 20092009Витязева И.И., Боголюбов С.В., Иловайская И.А., Макарова Н.П., Львова А.Г.Vityazeva I.I., Bogolyubov S.V., Ilovayskaya I.A., Makarova N.P., L'vova A.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/5695

Сахарный диабет (СД) повреждает функционирование репродуктивной системы на различных уровнях, у мужчин и у женщин. Происхо-дит нарушение центральной регуляции гипоталамо-гипофизарно-гонадной оси, снижение эндокринной функции половых желез, повреж-дение гонад на клеточном уровне за счет самого воздействия острой и / или хронической гипергликемии и развития оксидативногостресса, микрососудистых осложнений. Усугубление гормональных нарушений в свою очередь приводит к повреждению центральной ре-гуляции. Применение различных вспомогательных репродуктивных технологий (ВРТ) является возможным методом лечения бесплодияу мужчин и женщин с СД, однако многие аспекты проведения ВРТ еще требуют углубленного изучения.

Diabetes mellitus affects reproductive function at different levels both in men and women. It disturbs regulation of the hypothalamo-pituitary axisand impairs gonadal endocrine function at the cellular level due to direct effect of acute and/or chronic hyperglycemia, oxidative stress and microvascularcomplications. Moreover, central dysregulation aggravates hormonal disorders. Assisted reproductive technologies (ART) provide a tool for thetreatment of male and female infertility in diabetic patients although many aspects of its application await in-depth studies.

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The authors declare that there are no conflicts of interest present.