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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/2072-0351-5668</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-5668</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Ассоциация полиморфного маркера-23HphI гена INS с сахарным диабетом 1 типа</article-title><trans-title-group xml:lang="en"><trans-title>Association of -23 HphI, a polymorphic marker of the INS gene, with type 1 diabetes mellitus</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никитин</surname><given-names>Алексей Георгиевич</given-names></name><name name-style="western" xml:lang="en"><surname>Nikitin</surname><given-names>Aleksey Georgievich</given-names></name></name-alternatives><email xlink:type="simple">nikitin@genetika.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лаврикова</surname><given-names>Елена Юрьевна</given-names></name><name name-style="western" xml:lang="en"><surname>Lavrikova</surname><given-names>Elena Yur'evna</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Серегин</surname><given-names>Юрий Александрович</given-names></name><name name-style="western" xml:lang="en"><surname>Seregin</surname><given-names>Yury Alexandrovich</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зильберман</surname><given-names>Любовь Иосифовна</given-names></name><name name-style="western" xml:lang="en"><surname>Zil'berman</surname><given-names>Lyubov' Iosifovna</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цитлидзе</surname><given-names>Нана Михайловна</given-names></name><name name-style="western" xml:lang="en"><surname>Tsitlidze</surname><given-names>Nana Mikhailovna</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кураева</surname><given-names>Тамара Леонидовна</given-names></name><name name-style="western" xml:lang="en"><surname>Kuraeva</surname><given-names>Tamara Leonidovna</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петеркова</surname><given-names>Валентина Александровна</given-names></name><name name-style="western" xml:lang="en"><surname>Peterkova</surname><given-names>Valentina Alexandrovna</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дедов</surname><given-names>Иван Иванович</given-names></name><name name-style="western" xml:lang="en"><surname>Dedov</surname><given-names>Ivan Ivanovich</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Носиков</surname><given-names>Валерий Вячеславович</given-names></name><name name-style="western" xml:lang="en"><surname>Nosikov</surname><given-names>Valery Vyacheslavovich</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГУ Эндокринологический научный центр, Москва</institution></aff><aff xml:lang="en"><institution>Endocrinology Research Centre, Moscow</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГУП ГосНИИгенетика, Москва</institution></aff><aff xml:lang="en"><institution>State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>15</day><month>06</month><year>2010</year></pub-date><volume>13</volume><issue>2</issue><issue-title>№2 (2010)</issue-title><fpage>17</fpage><lpage>20</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Никитин А.Г., Лаврикова Е.Ю., Серегин Ю.А., Зильберман Л.И., Цитлидзе Н.М., Кураева Т.Л., Петеркова В.А., Дедов И.И., Носиков В.В., 2010</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="ru">Никитин А.Г., Лаврикова Е.Ю., Серегин Ю.А., Зильберман Л.И., Цитлидзе Н.М., Кураева Т.Л., Петеркова В.А., Дедов И.И., Носиков В.В.</copyright-holder><copyright-holder xml:lang="en">Nikitin A.G., Lavrikova E.Y., Seregin Y.A., Zil'berman L.I., Tsitlidze N.M., Kuraeva T.L., Peterkova V.A., Dedov I.I., Nosikov V.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/5668">https://www.dia-endojournals.ru/jour/article/view/5668</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>сахарный диабет 1 типа</kwd><kwd>полиморфный маркер</kwd><kwd>ассоциация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>23HphI</kwd><kwd>INS</kwd><kwd>type 1 diabetes mellitus</kwd><kwd>polymorphic marker</kwd><kwd>-23 HphI</kwd><kwd>INS</kwd><kwd>association</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Devendra D., Liu E., Eisenbarth G.S. Type 1 diabetes: recent developments // BMJ. - 2004. - 328 (7442). - P. 750-754.</mixed-citation><mixed-citation xml:lang="en">Devendra D., Liu E., Eisenbarth G.S. Type 1 diabetes: recent developments // BMJ. - 2004. - 328 (7442). - P. 750-754.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Knip M., Veijola R., Virtanen S.M., Hyцty H., Vaarala O., Akerblom H.K. Environmental triggers and determinants of type 1 diabetes // Diabetes. - 2005. - 54 Suppl. 2. - P. S125-136.</mixed-citation><mixed-citation xml:lang="en">Knip M., Veijola R., Virtanen S.M., Hyцty H., Vaarala O., Akerblom H.K. Environmental triggers and determinants of type 1 diabetes // Diabetes. - 2005. - 54 Suppl. 2. - P. S125-136.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Foulis A.K. The pathology of the endocrine pancreas in type 1 (insulin-dependent) diabetes mellitus // APMIS. - 1996. - 104 (3). - P. 161-167.</mixed-citation><mixed-citation xml:lang="en">Foulis A.K. The pathology of the endocrine pancreas in type 1 (insulin-dependent) diabetes mellitus // APMIS. - 1996. - 104 (3). - P. 161-167.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Miao D., Yu L., Eisenbarth G.S. Role of autoantibodies in type 1 diabetes // Front. Biosci. - 2007. - 12. - P. 1889-1898.</mixed-citation><mixed-citation xml:lang="en">Miao D., Yu L., Eisenbarth G.S. Role of autoantibodies in type 1 diabetes // Front. Biosci. - 2007. - 12. - P. 1889-1898.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Nerup J., Platz P., Andersen O.O., Christy M., Lyngsoe J., Poulsen J.E., Ryder L.P., Thomsen M., Nielsen L.S., Svejgaard A. HL-A ANTIGENS AND DIABETES MELLITUS // The Lancet. - 1974. - 304 (7885). - P. 864-866.</mixed-citation><mixed-citation xml:lang="en">Nerup J., Platz P., Andersen O.O., Christy M., Lyngsoe J., Poulsen J.E., Ryder L.P., Thomsen M., Nielsen L.S., Svejgaard A. HL-A ANTIGENS AND DIABETES MELLITUS // The Lancet. - 1974. - 304 (7885). - P. 864-866.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Noble J.A., Valdes A.M., Cook M., Klitz W., Thomson G., Erlich H.A. The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families // Am. J. Hum. Genet. - 1996. - 59 (5). - P. 1134-1148.</mixed-citation><mixed-citation xml:lang="en">Noble J.A., Valdes A.M., Cook M., Klitz W., Thomson G., Erlich H.A. The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families // Am. J. Hum. Genet. - 1996. - 59 (5). - P. 1134-1148.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Cucca F., Lampis R., Congia M., Angius E., Nutland S., Bain S.C., Barnett A.H., Todd J.A. A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins // Hum. Mol. Genet. - 2001. - 10 (19). - P. 2025-2037.</mixed-citation><mixed-citation xml:lang="en">Cucca F., Lampis R., Congia M., Angius E., Nutland S., Bain S.C., Barnett A.H., Todd J.A. A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins // Hum. Mol. Genet. - 2001. - 10 (19). - P. 2025-2037.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kelly M.A., Rayner M.L., Mijovic C.H., Barnett A.H. Molecular aspects of type 1 diabetes // Mol Pathol. - 2003. - 56 (1). - P. 1-10.</mixed-citation><mixed-citation xml:lang="en">Kelly M.A., Rayner M.L., Mijovic C.H., Barnett A.H. Molecular aspects of type 1 diabetes // Mol Pathol. - 2003. - 56 (1). - P. 1-10.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Devendra D., Eisenbarth G.S. 17. Immunologic endocrine disorders // J. Allergy Clin. Immunol. - 2003. - 111 (2 Suppl). - P. S624-636.</mixed-citation><mixed-citation xml:lang="en">Devendra D., Eisenbarth G.S. 17. Immunologic endocrine disorders // J. Allergy Clin. Immunol. - 2003. - 111 (2 Suppl). - P. S624-636.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Bell G.I., Horita S., Karam J.H. A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus // Diabetes. - 1984. - 33 (2). - P. 176-183.</mixed-citation><mixed-citation xml:lang="en">Bell G.I., Horita S., Karam J.H. A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus // Diabetes. - 1984. - 33 (2). - P. 176-183.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Owerbach D., Gabbay K.H. Linkage of the VNTR/insulin-gene and type I diabetes mellitus: increased gene sharing in affected sibling pairs // Am. J. Hum. Genet. - 1994. - 54 (5). - P. 909-912.</mixed-citation><mixed-citation xml:lang="en">Owerbach D., Gabbay K.H. Linkage of the VNTR/insulin-gene and type I diabetes mellitus: increased gene sharing in affected sibling pairs // Am. J. Hum. Genet. - 1994. - 54 (5). - P. 909-912.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Lucassen A.M., Julier C., Beressi J., Boitard C., Froguel P., Lathrop M., Bell J.I. Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR // Nat. Genet. - 1993. - 4 (3). - P. 305-310.</mixed-citation><mixed-citation xml:lang="en">Lucassen A.M., Julier C., Beressi J., Boitard C., Froguel P., Lathrop M., Bell J.I. Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR // Nat. Genet. - 1993. - 4 (3). - P. 305-310.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bennett S.T., Lucassen A.M., Gough S.C., Powell E.E., Undlien D.E., Pritchard L.E., Merriman M.E., Kawaguchi Y., Dronsfield M.J., Pociot F. Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus // Nat. Genet. - 1995. - 9 (3). - P. 284-292.</mixed-citation><mixed-citation xml:lang="en">Bennett S.T., Lucassen A.M., Gough S.C., Powell E.E., Undlien D.E., Pritchard L.E., Merriman M.E., Kawaguchi Y., Dronsfield M.J., Pociot F. Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus // Nat. Genet. - 1995. - 9 (3). - P. 284-292.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Undlien D.E., Bennett S.T., Todd J.A., Akselsen H.E., Ikдheimo I., Reijonen H., Knip M., Thorsby E., Rшnningen K.S. Insulin gene region-encoded susceptibility to IDDM maps upstream of the insulin gene // Diabetes. - 1995. - 44 (6). - P. 620-625.</mixed-citation><mixed-citation xml:lang="en">Undlien D.E., Bennett S.T., Todd J.A., Akselsen H.E., Ikдheimo I., Reijonen H., Knip M., Thorsby E., Rшnningen K.S. Insulin gene region-encoded susceptibility to IDDM maps upstream of the insulin gene // Diabetes. - 1995. - 44 (6). - P. 620-625.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Kristiansen O.P., Larsen Z.M., Pociot F. CTLA-4 in autoimmune diseases-a general susceptibility gene to autoimmunity? // Genes Immun. - 2000. - 1 (3). - P. 170-184.</mixed-citation><mixed-citation xml:lang="en">Kristiansen O.P., Larsen Z.M., Pociot F. CTLA-4 in autoimmune diseases-a general susceptibility gene to autoimmunity? // Genes Immun. - 2000. - 1 (3). - P. 170-184.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ueda H., Howson J.M.M., Esposito L., Heward J., Snook, Chamberlain G., Rainbow D.B., Hunter K.M.D., Smith A.N., Di Genova G., Herr M.H., Dahlman I., Payne F., Smyth D., Lowe C., Twells R.C.J., Howlett S., Healy B., Nutland S., Rance H.E., Everett V., Smink L.J., Lam A.C., Cordell H.J., Walker N.M., Bordin C., Hulme J., Motzo C., Cucca F., Hess J.F., Metzker M.L., Rogers J., Gregory S., Allahabadia A., Nithiyananthan R., Tuomilehto-Wolf E., Tuomilehto J., Bingley P., Gillespie K.M., Undlien D.E., Ronningen K.S., Guja C., Ionescu-Tirgoviste C., Savage D.A., Maxwell A.P., Carson D.J., Patterson C.C., Franklyn J.A., Clayton D.G., Peterson L.B., Wicker L.S., Todd J.A., Gough S.C.L. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease // Nature. - 2003. - 423 (6939). - P. 506-511.</mixed-citation><mixed-citation xml:lang="en">Ueda H., Howson J.M.M., Esposito L., Heward J., Snook, Chamberlain G., Rainbow D.B., Hunter K.M.D., Smith A.N., Di Genova G., Herr M.H., Dahlman I., Payne F., Smyth D., Lowe C., Twells R.C.J., Howlett S., Healy B., Nutland S., Rance H.E., Everett V., Smink L.J., Lam A.C., Cordell H.J., Walker N.M., Bordin C., Hulme J., Motzo C., Cucca F., Hess J.F., Metzker M.L., Rogers J., Gregory S., Allahabadia A., Nithiyananthan R., Tuomilehto-Wolf E., Tuomilehto J., Bingley P., Gillespie K.M., Undlien D.E., Ronningen K.S., Guja C., Ionescu-Tirgoviste C., Savage D.A., Maxwell A.P., Carson D.J., Patterson C.C., Franklyn J.A., Clayton D.G., Peterson L.B., Wicker L.S., Todd J.A., Gough S.C.L. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease // Nature. - 2003. - 423 (6939). - P. 506-511.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Nistico L., Buzzetti R., Pritchard L., Van der Auwera B., Giovannini C., Bosi E., Larrad M., Rios M., Chow C., Cockram C., Jacobs K., Mijovic C., Bain S., Barnett A., Vandewalle C., Schuit F., Gorus F., Tosi R., Pozzilli P., Todd J. The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry // Hum. Mol. Genet. - 1996. - 5 (7). - P. 1075-1080.</mixed-citation><mixed-citation xml:lang="en">Nistico L., Buzzetti R., Pritchard L., Van der Auwera B., Giovannini C., Bosi E., Larrad M., Rios M., Chow C., Cockram C., Jacobs K., Mijovic C., Bain S., Barnett A., Vandewalle C., Schuit F., Gorus F., Tosi R., Pozzilli P., Todd J. The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry // Hum. Mol. Genet. - 1996. - 5 (7). - P. 1075-1080.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Smyth D., Cooper J.D., Collins J.E., Heward J.M., Franklyn J.A., Howson J.M.M., Vella A., Nutland S., Rance H.E., Maier L., Barratt B.J., Guja C., Ionescu-Tоrgoviste C., Savage D.A., Dunger D.B., Widmer B., Strachan D.P., Ring S.M., Walker N., Clayton D.G., Twells R.C.J., Gough S.C.L., Todd J.A. Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus // Diabetes. - 2004. - 53 (11). - P. 3020- 3023.</mixed-citation><mixed-citation xml:lang="en">Smyth D., Cooper J.D., Collins J.E., Heward J.M., Franklyn J.A., Howson J.M.M., Vella A., Nutland S., Rance H.E., Maier L., Barratt B.J., Guja C., Ionescu-Tоrgoviste C., Savage D.A., Dunger D.B., Widmer B., Strachan D.P., Ring S.M., Walker N., Clayton D.G., Twells R.C.J., Gough S.C.L., Todd J.A. Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus // Diabetes. - 2004. - 53 (11). - P. 3020- 3023.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Onengut-Gumuscu S., Ewens K.G., Spielman R.S., Concannon P. A functional polymorphism (1858C//T) in the PTPN22 gene is linked and associated with type I diabetes in multiplex families // Genes Immun. - 2004. - 5 (8). - P. 678-680.</mixed-citation><mixed-citation xml:lang="en">Onengut-Gumuscu S., Ewens K.G., Spielman R.S., Concannon P. A functional polymorphism (1858C//T) in the PTPN22 gene is linked and associated with type I diabetes in multiplex families // Genes Immun. - 2004. - 5 (8). - P. 678-680.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Bottini N., Musumeci L., Alonso A., Rahmouni S., Nika K., RostamkhaniM., MacMurray J., Meloni G.F., Lucarelli P., Pellecchia M., Eisenbarth G.S., Comings D., Mustelin T. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes // Nat. Genet. - 2004. - 36 (4). - P. 337- 338.</mixed-citation><mixed-citation xml:lang="en">Bottini N., Musumeci L., Alonso A., Rahmouni S., Nika K., RostamkhaniM., MacMurray J., Meloni G.F., Lucarelli P., Pellecchia M., Eisenbarth G.S., Comings D., Mustelin T. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes // Nat. Genet. - 2004. - 36 (4). - P. 337- 338.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Qu H., Tessier M., Hudson T.J., Polychronakos C. Confirmation of the association of the R620W polymorphism in the protein tyrosine phosphatase PTPN22 with type 1 diabetes in a family based study // J. Med. Genet. - 2005. - 42 (3). - P. 266-270.</mixed-citation><mixed-citation xml:lang="en">Qu H., Tessier M., Hudson T.J., Polychronakos C. Confirmation of the association of the R620W polymorphism in the protein tyrosine phosphatase PTPN22 with type 1 diabetes in a family based study // J. Med. Genet. - 2005. - 42 (3). - P. 266-270.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Kennedy G.C., German M.S., Rutter W.J. The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription // Nat. Genet. - 1995. - 9 (3). - P. 293-298.</mixed-citation><mixed-citation xml:lang="en">Kennedy G.C., German M.S., Rutter W.J. The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription // Nat. Genet. - 1995. - 9 (3). - P. 293-298.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Vafiadis P., Bennett S.T., Todd J.A., Nadeau J., Grabs R., Goodyer C.G., Wickramasinghe S., Colle E., Polychronakos C. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus //Nat. Genet. - 1997. - 15 (3). - P. 289-292.</mixed-citation><mixed-citation xml:lang="en">Vafiadis P., Bennett S.T., Todd J.A., Nadeau J., Grabs R., Goodyer C.G., Wickramasinghe S., Colle E., Polychronakos C. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus //Nat. Genet. - 1997. - 15 (3). - P. 289-292.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Pugliese A., Zeller M., Fernandez A., Zalcberg L.J., Bartlett R.J., Ricordi C., Pietropaolo M., Eisenbarth G.S., Bennett S.T., Patel D.D. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes //Nat. Genet. - 1997. - 15 (3). - P. 293-297.</mixed-citation><mixed-citation xml:lang="en">Pugliese A., Zeller M., Fernandez A., Zalcberg L.J., Bartlett R.J., Ricordi C., Pietropaolo M., Eisenbarth G.S., Bennett S.T., Patel D.D. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes //Nat. Genet. - 1997. - 15 (3). - P. 293-297.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Le Stunff C., Fallin D., Schork N.J., Bougnиres P. The insulin gene VNTR is associated with fasting insulin levels and development of juvenile obesity // Nat. Genet. - 2000. - 26 (4). - P. 444-446.</mixed-citation><mixed-citation xml:lang="en">Le Stunff C., Fallin D., Schork N.J., Bougnиres P. The insulin gene VNTR is associated with fasting insulin levels and development of juvenile obesity // Nat. Genet. - 2000. - 26 (4). - P. 444-446.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Bell G.I., Selby M.J., Rutter W.J. The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences // Nature. - 1982. - 295 (5844). - P. 31-35.</mixed-citation><mixed-citation xml:lang="en">Bell G.I., Selby M.J., Rutter W.J. The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences // Nature. - 1982. - 295 (5844). - P. 31-35.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Krбlovicovб J., Gaunt T.R., Rodriguez S., Wood P.J., Day I.N.M., Vorechovsky I. Variants in the human insulin gene that affect pre-mRNA splicing: is -23HphI a functional single nucleotide polymorphism at IDDM2? // Diabetes. - 2006. - 55 (1). - P. 260-264.</mixed-citation><mixed-citation xml:lang="en">Krбlovicovб J., Gaunt T.R., Rodriguez S., Wood P.J., Day I.N.M., Vorechovsky I. Variants in the human insulin gene that affect pre-mRNA splicing: is -23HphI a functional single nucleotide polymorphism at IDDM2? // Diabetes. - 2006. - 55 (1). - P. 260-264.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Laub O., Rutter W. Expression of the human insulin gene and cDNA in a heterologous mammalian system // J. Biol. Chem. - 1983. - 258 (10). - P. 6043-6050.</mixed-citation><mixed-citation xml:lang="en">Laub O., Rutter W. Expression of the human insulin gene and cDNA in a heterologous mammalian system // J. Biol. Chem. - 1983. - 258 (10). - P. 6043-6050.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Marchand L., Polychronakos C. Evaluation of polymorphic splicing in the mechanism of the association of the insulin gene with diabetes // Diabetes. - 2007. - 56 (3). - P. 709-713.</mixed-citation><mixed-citation xml:lang="en">Marchand L., Polychronakos C. Evaluation of polymorphic splicing in the mechanism of the association of the insulin gene with diabetes // Diabetes. - 2007. - 56 (3). - P. 709-713.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Johns M.B., Paulus-Thomas J.E. Purification of human genomic DNA from whole blood using sodium perchlorate in place of phenol // Anal. Biochem. - 1989. - 180 (2). - P. 276-278.</mixed-citation><mixed-citation xml:lang="en">Johns M.B., Paulus-Thomas J.E. Purification of human genomic DNA from whole blood using sodium perchlorate in place of phenol // Anal. Biochem. - 1989. - 180 (2). - P. 276-278.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Калькулятор для расчета статистики в исследованиях "случай-конт- роль" [http://test.tapotili.ru/calculator_or.php].</mixed-citation><mixed-citation xml:lang="en">Калькулятор для расчета статистики в исследованиях "случай-конт- роль" [http://test.tapotili.ru/calculator_or.php].</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Kozak M. Leader length and secondary structure modulate mRNA function under conditions of stress // Mol. Cell. Biol. - 1988. - 8 (7). - P. 2737- 2744.</mixed-citation><mixed-citation xml:lang="en">Kozak M. Leader length and secondary structure modulate mRNA function under conditions of stress // Mol. Cell. Biol. - 1988. - 8 (7). - P. 2737- 2744.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Sospedra M., Ferrer-Francesch X., Dominguez O., Juan M., Foz-SalaM., Pujol-Borrell R. Transcription of a broad range of self-antigens in human thymus suggests a role for central mechanisms in tolerance toward peripheral antigens // J. Immunol. - 1998. - 161 (11). - P. 5918-5929.</mixed-citation><mixed-citation xml:lang="en">Sospedra M., Ferrer-Francesch X., Dominguez O., Juan M., Foz-SalaM., Pujol-Borrell R. Transcription of a broad range of self-antigens in human thymus suggests a role for central mechanisms in tolerance toward peripheral antigens // J. Immunol. - 1998. - 161 (11). - P. 5918-5929.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Kent S.C., Chen Y., Bregoli L., Clemmings S.M., Kenyon N.S., Ricordi C., Hering B.J., Hafler D.A. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope // Nature. - 2005. - 435 (7039). - P. 224-228.</mixed-citation><mixed-citation xml:lang="en">Kent S.C., Chen Y., Bregoli L., Clemmings S.M., Kenyon N.S., Ricordi C., Hering B.J., Hafler D.A. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope // Nature. - 2005. - 435 (7039). - P. 224-228.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Hassainya Y., Garcia-Pons F., Kratzer R., Lindo V., Greer F., Lemonnier F.A., Niedermann G., van Endert P.M. Identification of naturally processed HLAA2- restricted proinsulin epitopes by reverse immunology // Diabetes. - 2005. - 54 (7). - P. 2053-2059.</mixed-citation><mixed-citation xml:lang="en">Hassainya Y., Garcia-Pons F., Kratzer R., Lindo V., Greer F., Lemonnier F.A., Niedermann G., van Endert P.M. Identification of naturally processed HLAA2- restricted proinsulin epitopes by reverse immunology // Diabetes. - 2005. - 54 (7). - P. 2053-2059.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Kent S., Hafler D. OR.72. Enhanced Recognition of Insulin a Chain 1-15 By Expanded T-Cell Clones from Human Type 1 Diabetic (T1D) Pancreatic Draining Lymph Nodes // Clinical Immunology. - 2006. - 119 (Supplement 1). - P. S30-S31.</mixed-citation><mixed-citation xml:lang="en">Kent S., Hafler D. OR.72. Enhanced Recognition of Insulin a Chain 1-15 By Expanded T-Cell Clones from Human Type 1 Diabetic (T1D) Pancreatic Draining Lymph Nodes // Clinical Immunology. - 2006. - 119 (Supplement 1). - P. S30-S31.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Pugliese A., Brown D., Garza D., Murchison D., Zeller M., Redondo M.J., Redondo M., Diez J., Eisenbarth G.S., Patel D.D., Ricordi C. Self-antigenpresenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs // J. Clin. Invest. - 2001. - 107 (5). - P. 555-564.</mixed-citation><mixed-citation xml:lang="en">Pugliese A., Brown D., Garza D., Murchison D., Zeller M., Redondo M.J., Redondo M., Diez J., Eisenbarth G.S., Patel D.D., Ricordi C. Self-antigenpresenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs // J. Clin. Invest. - 2001. - 107 (5). - P. 555-564.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Hansen S.K., Gjesing A.P., Rasmussen S.K., Glьmer C., Urhammer S.A., Andersen G., Rose C.S., Drivsholm T., Torekov S.K., Jensen D.P., Ekstrшm C.T., Borch-Johnsen K., Jшrgensen T., McCarthy M.I., Hansen T., Pedersen O. Large-scale studies of the HphI insulin gene variable-numberof- tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release // Diabetologia. - 2004. - 47 (6). - P. 1079-1087.</mixed-citation><mixed-citation xml:lang="en">Hansen S.K., Gjesing A.P., Rasmussen S.K., Glьmer C., Urhammer S.A., Andersen G., Rose C.S., Drivsholm T., Torekov S.K., Jensen D.P., Ekstrшm C.T., Borch-Johnsen K., Jшrgensen T., McCarthy M.I., Hansen T., Pedersen O. Large-scale studies of the HphI insulin gene variable-numberof- tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release // Diabetologia. - 2004. - 47 (6). - P. 1079-1087.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Nakayama M., Abiru N., Moriyama H., Babaya N., Liu E., Miao D., Yu L., Wegmann D.R., Hutton J.C., Elliott J.F., Eisenbarth G.S. Prime role for an insulin epitope in the development of type[thinsp]1 diabetes in NOD mice // Nature. - 2005. - 435 (7039). - P. 220-223.</mixed-citation><mixed-citation xml:lang="en">Nakayama M., Abiru N., Moriyama H., Babaya N., Liu E., Miao D., Yu L., Wegmann D.R., Hutton J.C., Elliott J.F., Eisenbarth G.S. Prime role for an insulin epitope in the development of type[thinsp]1 diabetes in NOD mice // Nature. - 2005. - 435 (7039). - P. 220-223.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Schatz D.A., Bingley P.J. Update on major trials for the prevention of type 1 diabetes mellitus: the American Diabetes Prevention Trial (DPT-1) and the European Nicotinamide Diabetes Intervention Trial (ENDIT) // J. Pediatr. Endocrinol. Metab. - 2001. - 14 Suppl 1. - P. 619-622.</mixed-citation><mixed-citation xml:lang="en">Schatz D.A., Bingley P.J. Update on major trials for the prevention of type 1 diabetes mellitus: the American Diabetes Prevention Trial (DPT-1) and the European Nicotinamide Diabetes Intervention Trial (ENDIT) // J. Pediatr. Endocrinol. Metab. - 2001. - 14 Suppl 1. - P. 619-622.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Skyler J.S., Krischer J.P., Wolfsdorf J., Cowie C., Palmer J.P., Greenbaum C., Cuthbertson D., Rafkin-Mervis L.E., Chase H.P., Leschek E. Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial-Type 1 // Diabetes Care. - 2005. - 28 (5). - P. 1068-1076.</mixed-citation><mixed-citation xml:lang="en">Skyler J.S., Krischer J.P., Wolfsdorf J., Cowie C., Palmer J.P., Greenbaum C., Cuthbertson D., Rafkin-Mervis L.E., Chase H.P., Leschek E. Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial-Type 1 // Diabetes Care. - 2005. - 28 (5). - P. 1068-1076.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Hermann R., Laine A., Veijola R., Vahlberg T., Simell S., Lдhde J., Simell O., Knip M., Ilonen J. The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral beta cell autoimmunity // Diabetologia. - 2005. - 48 (9). - P. 1766-1775.</mixed-citation><mixed-citation xml:lang="en">Hermann R., Laine A., Veijola R., Vahlberg T., Simell S., Lдhde J., Simell O., Knip M., Ilonen J. The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral beta cell autoimmunity // Diabetologia. - 2005. - 48 (9). - P. 1766-1775.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Skyler J.S., Greenbaum C.J., Lachin J.M., Leschek E., Rafkin-Mervis L., Savage P., Spain L. Type 1 Diabetes TrialNet-an international collaborative clinical trials network // Ann. N. Y. Acad. Sci. - 2008. - 1150. - P. 14- 24.</mixed-citation><mixed-citation xml:lang="en">Skyler J.S., Greenbaum C.J., Lachin J.M., Leschek E., Rafkin-Mervis L., Savage P., Spain L. Type 1 Diabetes TrialNet-an international collaborative clinical trials network // Ann. N. Y. Acad. Sci. - 2008. - 1150. - P. 14- 24.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Kyewski B., Derbinski J. Self-representation in the thymus: an extended view // Nat. Rev. Immunol. - 2004. - 4 (9). - P. 688-698.</mixed-citation><mixed-citation xml:lang="en">Kyewski B., Derbinski J. Self-representation in the thymus: an extended view // Nat. Rev. Immunol. - 2004. - 4 (9). - P. 688-698.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Palumbo M.O., Levi D., Chentoufi A.A., Polychronakos C. Isolation and characterization of proinsulin-producing medullary thymic epithelial cell clones // Diabetes. - 2006. - 55 (9). - P. 2595-2601.</mixed-citation><mixed-citation xml:lang="en">Palumbo M.O., Levi D., Chentoufi A.A., Polychronakos C. Isolation and characterization of proinsulin-producing medullary thymic epithelial cell clones // Diabetes. - 2006. - 55 (9). - P. 2595-2601.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
