diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/2072-0351-5636diaendo-5636Research ArticleСтатьиArticlesИнгибиторы дипептидилпептидазы-4 в лечении сахарного диабета 2 типа. Возможности кардиопротекцииDipeptidylpeptidase-4 inhibitors in the treatment of diabetes mellitus. Possibilities of cardioprotectionТрунинаЕлена НиколаевнаTruninaElena Nikolaevna-ПетунинаНина АлександровнаPetuninaNina Alexandrovna-ЧорбинскаяСветлана АлексеевнаChorbinskayaSvetlana Alekseevnaunc@pmc.ru, unmc@yandex.ruУНМЦ Управления делами Президента РФ, МоскваMedical Centre, Management Department of Presidential Administration, MoscowГОУ ВПО Первый московский государственный медицинский университет им. И.М. Сеченова, МоскваI.M.Sechenov First Moscow State Medical University, Moscow201115062011142№2 (2011)5964Copyright © Трунина Е.Н., Петунина Н.А., Чорбинская С.А., 20112011Трунина Е.Н., Петунина Н.А., Чорбинская С.А.Trunina E.N., Petunina N.A., Chorbinskaya S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/5636

Сахарный диабет 2 типа (СД2) - прогрессирующее заболевание, при котором традиционные методы лечения, такие как изменениеобраза жизни, применение препаратов сульфонилмочевины, метформина, глитазонов в качестве монотерапии, оказываются вто-рично неэффективны в течение относительно короткого времени. Открытие и внедрение новых гипогликемизирующих препаратов,таких как ингибиторы дипептидилпептидазы-4 (ДПП-4), обеспечивают возможность дальнейшего улучшения гликемического кон-троля. В обзоре собраны данные о механизмах действия, эффективности, безопасности применения ингибиторов ДПП-4 (на примереситаглиптина) при лечении СД2, а также данные об их потенциальном влиянии на сердечно-сосудистую систему.

Type 2 diabetes mellitus is a disease in which traditional therapeutic strategies, such as optimization of the lifestyle, intake of metformin and sulfonylureasor glitazone prove secondarily inefficient in the short run. The discovery and use of new hypoglycemic agents, e.g. DPP-4 inhibitors, openup opportunities for the further improvement of glycemic control. This review contains data on mechanisms of action, efficacy and safety of DPP-4inhibitors exemplified by sitagliptin and their possible effects on the cardiovascular system.

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The authors declare that there are no conflicts of interest present.