References

diaendo

Сахарный диабет

Diabetes mellitus

2072-03512072-0378

Endocrinology research centre

10.14341/2072-0351-5629

diaendo-5629

Research Article

Статьи

Articles

Диагностическая и прогностическая значимость аутоантител при сахарном диабете. Новый маркер аутоиммунного процесса - антитела к ZnT8

Diagnostic and prognostic value of autoantibodies for diabetes mellitus. A novel T1D autoimmunity target - zinc transporter 8 (ZnT8)

Шаповальянц

Ольга Сергеевна

Shapoval'yants

Olga Sergeevna

shapovalyants@yahoo.com

Никонова

Татьяна Васильевна

Nikonova

Tatiana Vasil'evna

ФГУ Эндокринологический научный центр, МоскваEndocrinological Research Centre, Moscow

2011

15062011

142

№2 (2011)

1822

2011

Шаповальянц О.С., Никонова Т.В.

Shapoval'yants O.S., Nikonova T.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.dia-endojournals.ru/jour/article/view/5629

Прогрессирующее снижение массы ?-клеток при диабете 1 типа (СД1) является результатом хронической аутоиммунной атаки, на-правленной против разнообразных молекул, экспрессируемых ?-клетками поджелудочной железы. Изменение клеточного и гуморальногоаутоиммунитета предшествует клиническим проявлением СД1. В настоящее время определены антигены, участвующие в патогенезеСД1, - глутаматдекарбоксилаза (ГДК), фосфотирозинфосфатаза, инсулин, островковые клетки поджелудочной железы. Недавноопределен новый аутоантиген - транспортер цинка 8 (ZnT8; Slc30A8).

The progressive loss of beta cells in Type 1 Diabetes (T1D) is a result of chronic autoimmune attack targeted at diverse molecules expressing in thepancreatic beta cells. The appearance of cellular and humoral autoimmunity precedes the clinical manifestation of T1D. There are several autoantigenswhich are supposed to be involved in pathogenesis of TD1. Zinc transporter 8 (ZnT8; Slc30A8) was identified as a novel T1D autoimmunitytarget.

сахарный диабет 1 типааутоантителаиммунитеттранспортер цинка 8

type 1 mellitus diabetesautoantibodiesimmunnityzinc transporter 8

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The authors declare that there are no conflicts of interest present.