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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/2072-0351-5545</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-5545</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Сахарный диабет 2 типа: новое показание для скрининга гиперкортицизма?</article-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus type 2: a new indication for hypercortisolism screening?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Волкова</surname><given-names>Наталья Ивановна</given-names></name><name name-style="western" xml:lang="en"><surname>Volkova</surname><given-names>Natalya Ivanovna</given-names></name></name-alternatives><email xlink:type="simple">n_i_volkova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Антоненко</surname><given-names>Мария Игоревна</given-names></name><name name-style="western" xml:lang="en"><surname>Antonenko</surname><given-names>Maria Igorevna</given-names></name></name-alternatives><email xlink:type="simple">n_i_volkova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ганенко</surname><given-names>Лилия Александровна</given-names></name><name name-style="western" xml:lang="en"><surname>Ganenko</surname><given-names>Liliya Alexandrovna</given-names></name></name-alternatives><email xlink:type="simple">n_i_volkova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО Ростовский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Medical State University of Rostov-on-Don</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>15</day><month>12</month><year>2012</year></pub-date><volume>15</volume><issue>4</issue><issue-title>№4 (2012)</issue-title><fpage>95</fpage><lpage>102</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Волкова Н.И., Антоненко М.И., Ганенко Л.А., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Волкова Н.И., Антоненко М.И., Ганенко Л.А.</copyright-holder><copyright-holder xml:lang="en">Volkova N.I., Antonenko M.I., Ganenko L.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/5545">https://www.dia-endojournals.ru/jour/article/view/5545</self-uri><abstract><p>В статье рассмотрены новые данные по частоте встречаемости гиперкортицизма без специфических симптомов в популяции пациентов с сахарным диабетом 2 типа. Подробно освещены трудности в диагностике и ведении данного состояния</p></abstract><trans-abstract xml:lang="en"><p>Current review discusses novel data concerning prevalence of Cushing syndrome without characteristic clinical signs among patients with type 2 diabetes mellitus. We also provide detailed analysis of difficulties in diagnostics and management of this condition</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гиперкортицизм</kwd><kwd>скрининг</kwd><kwd>сахарный диабет 2 типа</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hypercortysolism</kwd><kwd>screening</kwd><kwd>type 2 diabetes mellitus</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Dedov II, Mel'nichenko GA, Fadeev VV. Endokrinologiya, uchebnik dlya VUZov. Moscow; 2008.</mixed-citation><mixed-citation xml:lang="en">Dedov II, Mel'nichenko GA, Fadeev VV. Endokrinologiya, uchebnik dlya VUZov. Moscow; 2008.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Troshina EA, Bel'tsevich DG, Molashenko NV, Gazizova D.O. Diagnosis, differential diagnosis, and treatment of endogenous hypercorticism. Problemy endokrinologii. 2010;(2):53-63.</mixed-citation><mixed-citation xml:lang="en">Troshina EA, Bel'tsevich DG, Molashenko NV, Gazizova D.O. Diagnosis, differential diagnosis, and treatment of endogenous hypercorticism. Problemy endokrinologii. 2010;(2):53-63.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Nieman LK, Biller BM, Findling JW, Newell-Price J, Savage MO, Stewart PM, Montori VM. The Diagnosis of Cushing's Syndrome: An Endocrine Society Clin Pract Guideline. J Clin Endocrinol Metab. 2008 May;93(5):1526-1540. Epub 2008 Mar 11.</mixed-citation><mixed-citation xml:lang="en">Nieman LK, Biller BM, Findling JW, Newell-Price J, Savage MO, Stewart PM, Montori VM. The Diagnosis of Cushing's Syndrome: An Endocrine Society Clin Pract Guideline. J Clin Endocrinol Metab. 2008 May;93(5):1526-1540. Epub 2008 Mar 11.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Gatta B, Chabre O, Cortet C, Martinie M, Corcuff JB, Roger P, Tabarin A. Reevaluation of the combined dexamethasone suppression-corticotropin-releasing hormone test for differentiation of mild Cushing's disease from pseudo-Cushing's syndrome. J Clin Endocrinol Metab. 2007 Nov;92(11):4290-4293. Epub 2007 Jul 17.</mixed-citation><mixed-citation xml:lang="en">Gatta B, Chabre O, Cortet C, Martinie M, Corcuff JB, Roger P, Tabarin A. Reevaluation of the combined dexamethasone suppression-corticotropin-releasing hormone test for differentiation of mild Cushing's disease from pseudo-Cushing's syndrome. J Clin Endocrinol Metab. 2007 Nov;92(11):4290-4293. Epub 2007 Jul 17.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Pecori Giraldi F, Pivonello R, Ambrogio AG, De Martino MC, De Martin M, Scacchi M, Colao A, Toja PM, Lombardi G, Cavagnini F. The dexamethasone-suppressed corticotropin-releasing hormone stimulation test and the desmopressin test to distinguish Cushing's syndrome from pseudo-Cushing's states. Clin Endocrinol (Oxf). 2007 Feb;66(2):251-257.</mixed-citation><mixed-citation xml:lang="en">Pecori Giraldi F, Pivonello R, Ambrogio AG, De Martino MC, De Martin M, Scacchi M, Colao A, Toja PM, Lombardi G, Cavagnini F. The dexamethasone-suppressed corticotropin-releasing hormone stimulation test and the desmopressin test to distinguish Cushing's syndrome from pseudo-Cushing's states. Clin Endocrinol (Oxf). 2007 Feb;66(2):251-257.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ross EJ, Linch DC. Cushing's syndrome- killing disease: discriminatory value of signs and symptoms aiding early diagnosis. Lancet. 1982 Sep 18;2(8299):646-649.</mixed-citation><mixed-citation xml:lang="en">Ross EJ, Linch DC. Cushing's syndrome- killing disease: discriminatory value of signs and symptoms aiding early diagnosis. Lancet. 1982 Sep 18;2(8299):646-649.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Nagai T, Imamura M, Misumi S, Mori M. Subclinical Cushing's disease accompanied by malignant hypertension and diabetes mellitus. Intern Med. 2002 Jul;41(7):566-570.</mixed-citation><mixed-citation xml:lang="en">Nagai T, Imamura M, Misumi S, Mori M. Subclinical Cushing's disease accompanied by malignant hypertension and diabetes mellitus. Intern Med. 2002 Jul;41(7):566-570.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Minami I, Tateno T, Yoshimoto T, Doi M, Izumiyama H, Akashi T, Hirata Y. Subclinical Cushing's disease with amelioration of metabolic comorbidities after removal of pituitary tumor. Intern Med. 2006;45(21):1231-1235. Epub 2006 Dec 1.</mixed-citation><mixed-citation xml:lang="en">Minami I, Tateno T, Yoshimoto T, Doi M, Izumiyama H, Akashi T, Hirata Y. Subclinical Cushing's disease with amelioration of metabolic comorbidities after removal of pituitary tumor. Intern Med. 2006;45(21):1231-1235. Epub 2006 Dec 1.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Catargi B, Rigalleau V, Poussin A, Ronci-Chaix N, Bex V, Vergnot V, Gin H, Roger P, Tabarin A. Occult Cushing's syndrome in type-2 diabetes. J Clin Endocrinol Metab. 2003 Dec;88(12):5808-5813.</mixed-citation><mixed-citation xml:lang="en">Catargi B, Rigalleau V, Poussin A, Ronci-Chaix N, Bex V, Vergnot V, Gin H, Roger P, Tabarin A. Occult Cushing's syndrome in type-2 diabetes. J Clin Endocrinol Metab. 2003 Dec;88(12):5808-5813.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Chiodini I, Torlontano M, Scillitani A, Arosio M, Bacci S, Di Lembo S, Epaminonda P, Augello G, Enrini R, Ambrosi B, Adda G, Trischitta V. Association of subclinical hypercortisolism with type 2 diabetes mellitus: a case- control study in hospitalized patients. Eur J Endocrinol. 2005 Dec;153(6):837-844.</mixed-citation><mixed-citation xml:lang="en">Chiodini I, Torlontano M, Scillitani A, Arosio M, Bacci S, Di Lembo S, Epaminonda P, Augello G, Enrini R, Ambrosi B, Adda G, Trischitta V. Association of subclinical hypercortisolism with type 2 diabetes mellitus: a case- control study in hospitalized patients. Eur J Endocrinol. 2005 Dec;153(6):837-844.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Leibowitz G, Tsur A, Chayen SD, Salameh M, Raz I, Cerasi E, Gross DJ. Preclinical Cushing's syndrome: an unexpected frequent cause of poor glycaemic control in obese diabetic patients. Clin Endocrinol (Oxf). 1996 Jun;44(6):717-722.</mixed-citation><mixed-citation xml:lang="en">Leibowitz G, Tsur A, Chayen SD, Salameh M, Raz I, Cerasi E, Gross DJ. Preclinical Cushing's syndrome: an unexpected frequent cause of poor glycaemic control in obese diabetic patients. Clin Endocrinol (Oxf). 1996 Jun;44(6):717-722.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Reimondo G, Pia A, Allasino B, Tassone F, Bovio S, Borretta G, Angeli A, Terzolo M. Screening of Cushing' syndrome in adult patients with newly diagnosed diabetes mellitus. Clin Endocrinol (Oxf). 2007 Aug;67(2):225-229. Epub 2007 Jun 4.</mixed-citation><mixed-citation xml:lang="en">Reimondo G, Pia A, Allasino B, Tassone F, Bovio S, Borretta G, Angeli A, Terzolo M. Screening of Cushing' syndrome in adult patients with newly diagnosed diabetes mellitus. Clin Endocrinol (Oxf). 2007 Aug;67(2):225-229. Epub 2007 Jun 4.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Liu H, Bravata DM, Cabaccan J, Raff H, Ryzen E. Elevated late-night salivary cortisol levels in elderly male type 2 diabetic veterans. Clin Endocrinol (Oxf). 2005 Dec;63(6):642-649.</mixed-citation><mixed-citation xml:lang="en">Liu H, Bravata DM, Cabaccan J, Raff H, Ryzen E. Elevated late-night salivary cortisol levels in elderly male type 2 diabetic veterans. Clin Endocrinol (Oxf). 2005 Dec;63(6):642-649.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Mullan K, Black N, Thiraviaraj A, Bell PM, Burgess C, Hunter SJ, McCance DR, Leslie H, Sheridan B, Atkinson AB. Is there value in routine screening for Cushing's syndrome in patients with diabetes? J Clin Endocrinol Metab. 2010 May;95(5):2262-2265. Epub 2010 Mar 17.</mixed-citation><mixed-citation xml:lang="en">Mullan K, Black N, Thiraviaraj A, Bell PM, Burgess C, Hunter SJ, McCance DR, Leslie H, Sheridan B, Atkinson AB. Is there value in routine screening for Cushing's syndrome in patients with diabetes? J Clin Endocrinol Metab. 2010 May;95(5):2262-2265. Epub 2010 Mar 17.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Murakami H, Nigawara T, Sakihara S, Kageyama K, Yamashita M, Matsuki K, Tanabe J, Matsui J, Tamasawa N, Suda T. The frequency of type 2 diabetic patients who meet the endocrinological screening criteria of subclinical Cushing's disease. Endocr J. 2010;57(3):267-272. Epub 2010 Jan 19.</mixed-citation><mixed-citation xml:lang="en">Murakami H, Nigawara T, Sakihara S, Kageyama K, Yamashita M, Matsuki K, Tanabe J, Matsui J, Tamasawa N, Suda T. The frequency of type 2 diabetic patients who meet the endocrinological screening criteria of subclinical Cushing's disease. Endocr J. 2010;57(3):267-272. Epub 2010 Jan 19.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Newsome S, Chen K, Hoang J, Wilson JD, Potter JM, Hickman PE. Cushing's syndrome in a clinic population with diabetes. Intern Med J. 2008 Mar;38(3):178-182. Epub 2007 Jul 23.</mixed-citation><mixed-citation xml:lang="en">Newsome S, Chen K, Hoang J, Wilson JD, Potter JM, Hickman PE. Cushing's syndrome in a clinic population with diabetes. Intern Med J. 2008 Mar;38(3):178-182. Epub 2007 Jul 23.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Tabarin A, Perez P. Pros and cons of screening for occult Cushing syndrome. Nat Rev Endocrinol. 2011 Mar 22;7(8):445-455. doi: 10.1038/nrendo.2011.51.</mixed-citation><mixed-citation xml:lang="en">Tabarin A, Perez P. Pros and cons of screening for occult Cushing syndrome. Nat Rev Endocrinol. 2011 Mar 22;7(8):445-455. doi: 10.1038/nrendo.2011.51.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Holland WW, Stewart S, Masseria C. Screening in Europe. European Observatory on Health Systems and Policies. WHO 2008.</mixed-citation><mixed-citation xml:lang="en">Holland WW, Stewart S, Masseria C. Screening in Europe. European Observatory on Health Systems and Policies. WHO 2008.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Terzolo M, Pia A, Reimondo G. Subclinical Cushing's syndrome: definition and management. Clin Endocrinol (Oxf). 2012 Jan;76(1):12-18. doi: 10.1111/j.1365- 2265.2011.04253.x.</mixed-citation><mixed-citation xml:lang="en">Terzolo M, Pia A, Reimondo G. Subclinical Cushing's syndrome: definition and management. Clin Endocrinol (Oxf). 2012 Jan;76(1):12-18. doi: 10.1111/j.1365- 2265.2011.04253.x.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Clayton RN. Mortality in Cushing's disease. Neuroendocrinology. 2010;92 Suppl 1:71-76. Epub 2010 Sep 10.</mixed-citation><mixed-citation xml:lang="en">Clayton RN. Mortality in Cushing's disease. Neuroendocrinology. 2010;92 Suppl 1:71-76. Epub 2010 Sep 10.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Devenport L, Knehans A, Sundstrom A, Thomas T. Corticosterone's dual metabolic actions. Life Sci. 1989;45(15):1389-1396.</mixed-citation><mixed-citation xml:lang="en">Devenport L, Knehans A, Sundstrom A, Thomas T. Corticosterone's dual metabolic actions. Life Sci. 1989;45(15):1389-1396.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Sonino N, Boscaro M, Fallo F, Fava GA. A clinical index for rating severity in Cushing's syndrome. Psychother Psychosom. 2000 Jul-Aug;69(4):216-220.</mixed-citation><mixed-citation xml:lang="en">Sonino N, Boscaro M, Fallo F, Fava GA. A clinical index for rating severity in Cushing's syndrome. Psychother Psychosom. 2000 Jul-Aug;69(4):216-220.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Sarlis NJ, Chanock SJ, Nieman LK. Cortisolemic indices predict severe infections in Cushing's syndrome due to ectopic production of adrenocorticotropin. J Clin Endocrinol Metab. 2000 Jan;85(1):42-47.</mixed-citation><mixed-citation xml:lang="en">Sarlis NJ, Chanock SJ, Nieman LK. Cortisolemic indices predict severe infections in Cushing's syndrome due to ectopic production of adrenocorticotropin. J Clin Endocrinol Metab. 2000 Jan;85(1):42-47.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Sonino N, Fava GA, Raffi AR, Boscaro M, Fallo F. Clinical correlates of major depression in Cushing's disease. Psychopathology. 1998 Nov-Dec;31(6):302-306.</mixed-citation><mixed-citation xml:lang="en">Sonino N, Fava GA, Raffi AR, Boscaro M, Fallo F. Clinical correlates of major depression in Cushing's disease. Psychopathology. 1998 Nov-Dec;31(6):302-306.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Strack AM, Horsley CJ, Sebastian RJ, Akana SF, Dallman MF. Glucocorticoids and insulin: complex interaction on brown adipose tissue. Am J Physiol. 1995 May;268(5 Pt 2):R1209-1216.</mixed-citation><mixed-citation xml:lang="en">Strack AM, Horsley CJ, Sebastian RJ, Akana SF, Dallman MF. Glucocorticoids and insulin: complex interaction on brown adipose tissue. Am J Physiol. 1995 May;268(5 Pt 2):R1209-1216.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Webb SM, Badia X, Barahona MJ, Colao A, Strasburger CJ, Tabarin A, van Aken MO, Pivonello R, Stalla G, Lamberts SW, Glusman JE. Evaluation of health-related quality of life in patients with Cushing's syndrome with a new questionnaire. Eur J Endocrinol. 2008 May;158(5):623- 630.</mixed-citation><mixed-citation xml:lang="en">Webb SM, Badia X, Barahona MJ, Colao A, Strasburger CJ, Tabarin A, van Aken MO, Pivonello R, Stalla G, Lamberts SW, Glusman JE. Evaluation of health-related quality of life in patients with Cushing's syndrome with a new questionnaire. Eur J Endocrinol. 2008 May;158(5):623- 630.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Storr HL, Chan LF, Grossman AB, Savage MO. Paediatric Cushing's syndrome: epidemiology, investigation and therapeutic advances. Trends Endocrinol Metab. 2007 May-Jun;18(4):167-174. Epub 2007 Apr 6.</mixed-citation><mixed-citation xml:lang="en">Storr HL, Chan LF, Grossman AB, Savage MO. Paediatric Cushing's syndrome: epidemiology, investigation and therapeutic advances. Trends Endocrinol Metab. 2007 May-Jun;18(4):167-174. Epub 2007 Apr 6.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Pecori Giraldi F, Moro M, Cavagnini F; Study Group on the Hypothalamo-Pituitary-Adrenal Axis of the Italian Society of Endocrinology. Gender-related differences in the presentation and course of Cushing's disease. J Clin Endocrinol Metab. 2003 Apr;88(4):1554-1558.</mixed-citation><mixed-citation xml:lang="en">Pecori Giraldi F, Moro M, Cavagnini F; Study Group on the Hypothalamo-Pituitary-Adrenal Axis of the Italian Society of Endocrinology. Gender-related differences in the presentation and course of Cushing's disease. J Clin Endocrinol Metab. 2003 Apr;88(4):1554-1558.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Wajngot A, Giacca A, Grill V, Vranic M, Efendic S. The diabetogenic effects of glucocorticoids are more pronounced in low-than in high-insulin responders. Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6035-6039.</mixed-citation><mixed-citation xml:lang="en">Wajngot A, Giacca A, Grill V, Vranic M, Efendic S. The diabetogenic effects of glucocorticoids are more pronounced in low-than in high-insulin responders. Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6035-6039.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">van Rossum EF, Lamberts SW. Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition. Recent Prog Horm Res. 2004;59:333-357.</mixed-citation><mixed-citation xml:lang="en">van Rossum EF, Lamberts SW. Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition. Recent Prog Horm Res. 2004;59:333-357.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Mancini T, Kola B, Mantero F, Boscaro M, Arnaldi G. High cardiovascular risk in patients with Cushing's syndrome according to 1999 WHO/ISH guidelines. Clin Endocrinol (Oxf). 2004 Dec;61(6):768-777.</mixed-citation><mixed-citation xml:lang="en">Mancini T, Kola B, Mantero F, Boscaro M, Arnaldi G. High cardiovascular risk in patients with Cushing's syndrome according to 1999 WHO/ISH guidelines. Clin Endocrinol (Oxf). 2004 Dec;61(6):768-777.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Yanovski JA, Cutler GB Jr, Chrousos GP, Nieman LK. Corticotropin-releasing hormone stimulation following low-dose dexamethasone administration. A new test to distinguish Cushing's syndrome from pseudo-Cushing's states. JAMA. 1993 May 5;269(17):2232-2238.</mixed-citation><mixed-citation xml:lang="en">Yanovski JA, Cutler GB Jr, Chrousos GP, Nieman LK. Corticotropin-releasing hormone stimulation following low-dose dexamethasone administration. A new test to distinguish Cushing's syndrome from pseudo-Cushing's states. JAMA. 1993 May 5;269(17):2232-2238.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Oltmanns KM, Dodt B, Schultes B, Raspe HH, Schweiger U, Born J, Fehm HL, Peters A. Cortisol correlates with metabolic disturbances in a population study of type 2 diabetic patients. Eur J Endocrinol. 2006 Feb;154(2):325- 331.</mixed-citation><mixed-citation xml:lang="en">Oltmanns KM, Dodt B, Schultes B, Raspe HH, Schweiger U, Born J, Fehm HL, Peters A. Cortisol correlates with metabolic disturbances in a population study of type 2 diabetic patients. Eur J Endocrinol. 2006 Feb;154(2):325- 331.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Roy MS, Roy A, Gallucci WT, Collier B, Young K, Kamilaris TC, Chrousos GP. The ovine corticotropin-releasing hormone-stimulation test in type I diabetic patients and controls: suggestion of mild chronic hypercortisolism. Metabolism. 1993 Jun;42(6):696-700.</mixed-citation><mixed-citation xml:lang="en">Roy MS, Roy A, Gallucci WT, Collier B, Young K, Kamilaris TC, Chrousos GP. The ovine corticotropin-releasing hormone-stimulation test in type I diabetic patients and controls: suggestion of mild chronic hypercortisolism. Metabolism. 1993 Jun;42(6):696-700.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Tsigos C, Young RJ, White A. Diabetic neuropathy is associated with increased activity of the hypothalamic- pituitary-adrenal axis. J Clin Endocrinol Metab. 1993 Mar;76(3):554-558.</mixed-citation><mixed-citation xml:lang="en">Tsigos C, Young RJ, White A. Diabetic neuropathy is associated with increased activity of the hypothalamic- pituitary-adrenal axis. J Clin Endocrinol Metab. 1993 Mar;76(3):554-558.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Fagour C, Bardet S, Rohmer V, Arimone Y, Lecomte P, Valli N, Tabarin A. Usefulness of adrenal scintigraphy in the follow-up of adrenocortical incidentalomas: a prospective multicenter study. Eur J Endocrinol. 2009 Feb;160(2):257- 264. Epub 2008 Oct 30.</mixed-citation><mixed-citation xml:lang="en">Fagour C, Bardet S, Rohmer V, Arimone Y, Lecomte P, Valli N, Tabarin A. Usefulness of adrenal scintigraphy in the follow-up of adrenocortical incidentalomas: a prospective multicenter study. Eur J Endocrinol. 2009 Feb;160(2):257- 264. Epub 2008 Oct 30.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Fletcher R, Fletcher S, Vagner E. Klinicheskaya epidemiologiya: Osnovy dokazatel'noy meditsiny. Moscow; 1998.</mixed-citation><mixed-citation xml:lang="en">Fletcher R, Fletcher S, Vagner E. Klinicheskaya epidemiologiya: Osnovy dokazatel'noy meditsiny. Moscow; 1998.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Stewart PM. Is subclinical Cushing's syndrome an entity or a statistical fallout from diagnostic testing? Consensus surrounding the diagnosis is required before optimal treatment can be defined. J Clin Endocrinol Metab. 2010 Jun;95(6):2618-2620.</mixed-citation><mixed-citation xml:lang="en">Stewart PM. Is subclinical Cushing's syndrome an entity or a statistical fallout from diagnostic testing? Consensus surrounding the diagnosis is required before optimal treatment can be defined. J Clin Endocrinol Metab. 2010 Jun;95(6):2618-2620.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Eller-Vainicher C, Morelli V, Salcuni AS, Torlontano M, Coletti F, Iorio L, Cuttitta A, Ambrosio A, Vicentini L, Carnevale V, Beck-Peccoz P, Arosio M, Ambrosi B, Scillitani A, Chiodini I. Post-surgical hypocortisolism after removal of an adrenal incidentaloma: is it predictable by an accurate endocrinological work-up before surgery. Eur J Endocrinol. 2010 Jan;162(1):91-99.</mixed-citation><mixed-citation xml:lang="en">Eller-Vainicher C, Morelli V, Salcuni AS, Torlontano M, Coletti F, Iorio L, Cuttitta A, Ambrosio A, Vicentini L, Carnevale V, Beck-Peccoz P, Arosio M, Ambrosi B, Scillitani A, Chiodini I. Post-surgical hypocortisolism after removal of an adrenal incidentaloma: is it predictable by an accurate endocrinological work-up before surgery. Eur J Endocrinol. 2010 Jan;162(1):91-99.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Gross KL, Cidlowski JA. Tissue-specific glucocorticoid action: a family affair. Trends Endocrinol Metab. 2008 Nov;19(9):331-339.</mixed-citation><mixed-citation xml:lang="en">Gross KL, Cidlowski JA. Tissue-specific glucocorticoid action: a family affair. Trends Endocrinol Metab. 2008 Nov;19(9):331-339.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Chiodini I, Morelli V, Salcuni AS, Eller-Vainicher C, Torlontano M, Coletti F, Iorio L, Cuttitta A, Ambrosio A, Vicentini L, Pellegrini F, Copetti M, Beck-Peccoz P, Arosio M, Ambrosi B, Trischitta V, Scillitani A. Beneficial metabolic effects of prompt surgical treatment in patients with an adrenal incidentaloma causing biochemical hypercortisolism. J Clin Endocrinol Metab. 2010 Jun;95(6):2736-2745.</mixed-citation><mixed-citation xml:lang="en">Chiodini I, Morelli V, Salcuni AS, Eller-Vainicher C, Torlontano M, Coletti F, Iorio L, Cuttitta A, Ambrosio A, Vicentini L, Pellegrini F, Copetti M, Beck-Peccoz P, Arosio M, Ambrosi B, Trischitta V, Scillitani A. Beneficial metabolic effects of prompt surgical treatment in patients with an adrenal incidentaloma causing biochemical hypercortisolism. J Clin Endocrinol Metab. 2010 Jun;95(6):2736-2745.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Guerrieri M, Campagnacci R, Patrizi A, Romiti C, Arnaldi G, Boscaro M. Primary adrenal hypercortisolism: minimally invasive surgical treatment or medical therapy? A retrospective study with long-term follow-up evaluation. Surg Endosc. 2010 Oct;24(10):2542-2546.</mixed-citation><mixed-citation xml:lang="en">Guerrieri M, Campagnacci R, Patrizi A, Romiti C, Arnaldi G, Boscaro M. Primary adrenal hypercortisolism: minimally invasive surgical treatment or medical therapy? A retrospective study with long-term follow-up evaluation. Surg Endosc. 2010 Oct;24(10):2542-2546.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Toniato A, Merante-Boschin I, Opocher G, Pelizzo MR, Schiavi F, Ballotta E. Surgical versus conservative management for subclinical Cushing's syndrome in adrenal incidentalomas: a prospective randomized study. Ann Surg. 2009 Mar;249(3):388-391.</mixed-citation><mixed-citation xml:lang="en">Toniato A, Merante-Boschin I, Opocher G, Pelizzo MR, Schiavi F, Ballotta E. Surgical versus conservative management for subclinical Cushing's syndrome in adrenal incidentalomas: a prospective randomized study. Ann Surg. 2009 Mar;249(3):388-391.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Sereg M, Szappanos A, Toke J, Karlinger K, Feldman K, Kaszper E, Varga I, Gláz E, Rácz K, Tóth M. Atherosclerotic risk factors and complications in patients with non-functioning adrenal adenomas treated with or without adrenalectomy: a long-term follow-up study. Eur J Endocrinol. 2009 Apr;160(4):647-655.</mixed-citation><mixed-citation xml:lang="en">Sereg M, Szappanos A, Toke J, Karlinger K, Feldman K, Kaszper E, Varga I, Gláz E, Rácz K, Tóth M. Atherosclerotic risk factors and complications in patients with non-functioning adrenal adenomas treated with or without adrenalectomy: a long-term follow-up study. Eur J Endocrinol. 2009 Apr;160(4):647-655.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Barahona MJ, Resmini E, Sucunza N, Webb SM. Diagnosis of cure in Cushing's syndrome: lessons from long-term follow-up. Front Horm Res. 2010;38:152-157.</mixed-citation><mixed-citation xml:lang="en">Barahona MJ, Resmini E, Sucunza N, Webb SM. Diagnosis of cure in Cushing's syndrome: lessons from long-term follow-up. Front Horm Res. 2010;38:152-157.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
