diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/2072-0351-5543diaendo-5543Research ArticleСтатьиArticlesДиабет, ожирение и онкологическая заболеваемость: риски и антирискиDiabetes, obesity and cancer: risk and anti-risk factorsБерштейнЛев МихайловичBershteynLev Mikhaylovichlevmb@endocrin.spb.ruФГБУ НИИ онкологии им. Н.Н. ПетроваРеюньонN.N.Petrov Research Institute of OncologyRéunion201215122012154№4 (2012)8188Copyright © Берштейн Л.М., 20122012Берштейн Л.М.Bershteyn L.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/5543

Современная эпидемия сахарного диабета и ожирения в качестве одного из своих следствий может приводить к изменению онкологической заболеваемости и смертности. Эта привлекающая все большее внимание проблема рассмотрена с позиций взаимодействия факторов, которые могут разнонаправленно модифицировать характер связи между диабетом и ожирением, с одной стороны, и злокачественными новообразованиями - с другой. Важные примеры таких факторов - гетерогенность и семейность диабета и ожирения, ассоциированные особенности генома, разнообразная антидиабетическая и весоредуцирующая терапия и т.д., на основе учета чего, не исключено, могут выстраиваться и эффективные меры профилактики.

Observable diabetes and obesity epidemics may result in alteration of cancer morbidity and mortality. This increasingly recognized problem is reviewed here from the perspective of interplay between factors that differently modify association of diabetes mellitus with malignant neoplasms. Heterogeneity and familial aspects of diabetes and obesity, genomic traits, anti-diabetic medications and weight-reducing treatment are important examples of such factors. Addressing them might promote development of efficient preventive measures.

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The authors declare that there are no conflicts of interest present.