diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/2072-0351-5536diaendo-5536Research ArticleСтатьиArticlesРоль провоспалительных факторов в оценке прогноза больных прогрессирующей стенокардией в сочетании с сахарным диабетом 2 типаPrognostic significance of proinflammatory factors in patients with progressive angina pectoris and type 2 diabetes mellitusБарбарашОльга ЛеонидовнаBarbarashOlga Leonidovna-СуминАлексей НиколаевичSuminAleksey Nikolaevich-АвраменкоОлеся ЕвгеньевнаAvramenkoOlesya Evgen'evna-ОсокинаАнастасия ВячеславовнаOsokinaAnastasia Vyacheslavovna-ВеремеевАлексей ВладимировичVeremeevAleksey Vladimirovich-ФГБУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний, Кемерово; ГБОУ ВПО Кемеровская государственная медицинская академия, КемеровоResearch Institute for complex issues of cardiovascular diseases, Kemerovo; Kemerovo State Medical Academy, KemerovoФГБУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний, КемеровоResearch Institute for complex issues of cardiovascular diseases, Kemerovo201215122012154№4 (2012)3945Copyright © Барбараш О.Л., Сумин А.Н., Авраменко О.Е., Осокина А.В., Веремеев А.В., 20122012Барбараш О.Л., Сумин А.Н., Авраменко О.Е., Осокина А.В., Веремеев А.В.Barbarash O.L., Sumin A.N., Avramenko O.E., Osokina A.V., Veremeev A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/5536нестабильная стенокардиянеспецифическое воспалениенеблагоприятный прогнозсахарный диабетunstable anginanon-specific inflammationunfavorable prognosisdiabetes mellitusReferencesRydén L, Standl E, Bartnik M, Van den Berghe G, Betteridge J, de Boer MJ, Cosentino F, Jönsson B, Laakso M, Malmberg K, Priori S, Ostergren J, Tuomilehto J, Thrainsdottir I, Vanhorebeek I, Stramba-Badiale M, Lindgren P, Qiao Q, Priori SG, Blanc JJ, Budaj A, Camm J, Dean V, Deckers J, Dickstein K, Lekakis J, McGregor K, Metra M, Morais J, Osterspey A, Tamargo J, Zamorano JL, Deckers JW, Bertrand M, Charbonnel B, Erdmann E, Ferrannini E, Flyvbjerg A, Gohlke H, Juanatey JR, Graham I, Monteiro PF, Parhofer K, Pyörälä K, Raz I, Schernthaner G, Volpe M, Wood D; Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC); European Association for the Study of Diabetes (EASD). Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). Eur Heart J. 2007 Jan;28(1):88- 136.Rydén L, Standl E, Bartnik M, Van den Berghe G, Betteridge J, de Boer MJ, Cosentino F, Jönsson B, Laakso M, Malmberg K, Priori S, Ostergren J, Tuomilehto J, Thrainsdottir I, Vanhorebeek I, Stramba-Badiale M, Lindgren P, Qiao Q, Priori SG, Blanc JJ, Budaj A, Camm J, Dean V, Deckers J, Dickstein K, Lekakis J, McGregor K, Metra M, Morais J, Osterspey A, Tamargo J, Zamorano JL, Deckers JW, Bertrand M, Charbonnel B, Erdmann E, Ferrannini E, Flyvbjerg A, Gohlke H, Juanatey JR, Graham I, Monteiro PF, Parhofer K, Pyörälä K, Raz I, Schernthaner G, Volpe M, Wood D; Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC); European Association for the Study of Diabetes (EASD). Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). Eur Heart J. 2007 Jan;28(1):88- 136.Arenillas JF, Candell-Riera J, Romero-Farina G, Molina CA, Chacón P, Aguadé-Bruix S, Montaner J, de León G, Castell-Conesa J, Alvarez-Sabín J. Silent myocardial ischemia in patients with symptomatic intracranial atherosclerosis: associated factors. Stroke. 2005 Jun;36(6):1201-1206. Epub 2005 May 5.Arenillas JF, Candell-Riera J, Romero-Farina G, Molina CA, Chacón P, Aguadé-Bruix S, Montaner J, de León G, Castell-Conesa J, Alvarez-Sabín J. Silent myocardial ischemia in patients with symptomatic intracranial atherosclerosis: associated factors. Stroke. 2005 Jun;36(6):1201-1206. Epub 2005 May 5.Gerber Y, Tanne D, Medalie JH, Goldbourt U. Serum uric acid and long-term mortality from stroke, coronary heart disease and all causes Eur J Cardiovasc Prev Rehabil. 2006 Apr;13(2):193-198.Gerber Y, Tanne D, Medalie JH, Goldbourt U. Serum uric acid and long-term mortality from stroke, coronary heart disease and all causes Eur J Cardiovasc Prev Rehabil. 2006 Apr;13(2):193-198.Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO 3rd, Criqui M, Fadl YY, Fortmann SP, Hong Y, Myers GL, Rifai N, Smith SC Jr, Taubert K, Tracy RP, Vinicor F; Centers for Disease Control and Prevention; American Heart Association. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003 Jan 28;107(3):499-511.Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO 3rd, Criqui M, Fadl YY, Fortmann SP, Hong Y, Myers GL, Rifai N, Smith SC Jr, Taubert K, Tracy RP, Vinicor F; Centers for Disease Control and Prevention; American Heart Association. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003 Jan 28;107(3):499-511.Rader DJ. Inflammatory markers of coronary risk. N Engl J Med. 2000 Oct 19;343(16):1179-1182.Rader DJ. Inflammatory markers of coronary risk. N Engl J Med. 2000 Oct 19;343(16):1179-1182.Başaran Y, Başaran MM, Babacan KF, Ener B, Okay T, Gök H, Ozdemir M. Serum tumor necrosis factor levels in acute myocardial infarction and unstable angina pectoris. Angiology. 1993 Apr;44(4):332-337.Başaran Y, Başaran MM, Babacan KF, Ener B, Okay T, Gök H, Ozdemir M. Serum tumor necrosis factor levels in acute myocardial infarction and unstable angina pectoris. Angiology. 1993 Apr;44(4):332-337.Berezhnaya NM. Cytokine network regulation in pathology: rapid progress in knowledge and inevitable questions. Cytokines and Inflammation. 2007; 6(2):26-34. [Russian]Berezhnaya NM. Cytokine network regulation in pathology: rapid progress in knowledge and inevitable questions. Cytokines and Inflammation. 2007; 6(2):26-34. [Russian]Zorina VN, Trofimenko NA, Arkhipova SV, Zorina RM, Zorin NA. Alpha-2-macroglobulin complexes with IgG antibodies, plasmin, and their interrelation with other factors of humoral immunity during the development of rheumatoid arthritis. Med. Immunol, 2005;7(5-6):557-562. [Russian]Zorina VN, Trofimenko NA, Arkhipova SV, Zorina RM, Zorin NA. Alpha-2-macroglobulin complexes with IgG antibodies, plasmin, and their interrelation with other factors of humoral immunity during the development of rheumatoid arthritis. Med. Immunol, 2005;7(5-6):557-562. [Russian]Oganov RG, Zakirova NE, Zakirova AN, Salakhova GM, Plotnikova MR. Immuno-inflamatory responses in acute coronary syndrome. Rational Pharmacother. Card. 2007;5:15-19. [Russian]Oganov RG, Zakirova NE, Zakirova AN, Salakhova GM, Plotnikova MR. Immuno-inflamatory responses in acute coronary syndrome. Rational Pharmacother. Card. 2007;5:15-19. [Russian]Apple FS, Wu AH, Mair J, Ravkilde J, Panteghini M, Tate J, Pagani F, Christenson RH, Mockel M, Danne O, Jaffe AS; Committee on Standardization of Markers of Cardiac Damage of the IFCC. Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome. Clin Chem. 2005 May;51(5):810-824. Epub 2005 Mar 17.Apple FS, Wu AH, Mair J, Ravkilde J, Panteghini M, Tate J, Pagani F, Christenson RH, Mockel M, Danne O, Jaffe AS; Committee on Standardization of Markers of Cardiac Damage of the IFCC. Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome. Clin Chem. 2005 May;51(5):810-824. Epub 2005 Mar 17.Shevchenko OD, Mishnev AO, Shevchenko OP. Ishemicheskaya bolezn' serdtsa. Moscow: Reafarm; 2005. 416 p. [Russian]Shevchenko OD, Mishnev AO, Shevchenko OP. Ishemicheskaya bolezn' serdtsa. Moscow: Reafarm; 2005. 416 p. [Russian]Behrendt D, Ganz P. Endothelial function. From vascular biology to clinical applications Am J Cardiol. 2002 Nov 21;90(10C):40L-48L.Behrendt D, Ganz P. Endothelial function. From vascular biology to clinical applications Am J Cardiol. 2002 Nov 21;90(10C):40L-48L.Scandinavian Simvastatin Survival Study Group. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994 Nov 19;344(8934):1383-1389.Scandinavian Simvastatin Survival Study Group. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994 Nov 19;344(8934):1383-1389.Kannel WB, Abbott RD. Incidence and prognosis of unrecognized myocardial infarction: an update on the Framingham study. N Engl J Med. 1984 Nov 1;311(18):1144-1147.Kannel WB, Abbott RD. Incidence and prognosis of unrecognized myocardial infarction: an update on the Framingham study. N Engl J Med. 1984 Nov 1;311(18):1144-1147.Ryabykina GV. Diagnostika ishemii miokarda metodom kholterovskogo monitorirovaniya EKG. Vestnik aritmologii. 2002; (26):5-10. [Russian]Ryabykina GV. Diagnostika ishemii miokarda metodom kholterovskogo monitorirovaniya EKG. Vestnik aritmologii. 2002; (26):5-10. [Russian]Alexandraki K, Piperi C, Kalofoutis C, Singh J, Alaveras A, Kalofoutis A. Inflammatory process in type 2 diabetes: the role of cytokines. Ann N Y Acad Sci. 2006 Nov;1084:89- 117.Alexandraki K, Piperi C, Kalofoutis C, Singh J, Alaveras A, Kalofoutis A. Inflammatory process in type 2 diabetes: the role of cytokines. Ann N Y Acad Sci. 2006 Nov;1084:89- 117.King DE, Mainous AG 3rd, Buchanan TA, Pearson WS. C - reactive protein and glycemic control in adult with diabetes. Diabetes Care. 2003 May;26(5):1535-1539.King DE, Mainous AG 3rd, Buchanan TA, Pearson WS. C - reactive protein and glycemic control in adult with diabetes. Diabetes Care. 2003 May;26(5):1535-1539.Bartnik M, Rydén L, Ferrari R, Malmberg K, Pyörälä K, Simoons M, Standl E, Soler-Soler J, Ohrvik J; Euro Heart Survey Investigators. The prevalence of abnormal glucose regulation in patients with coronary artery disease across Europe. Eur Heart J. 2004 Nov;25(21):1880-1890.Bartnik M, Rydén L, Ferrari R, Malmberg K, Pyörälä K, Simoons M, Standl E, Soler-Soler J, Ohrvik J; Euro Heart Survey Investigators. The prevalence of abnormal glucose regulation in patients with coronary artery disease across Europe. Eur Heart J. 2004 Nov;25(21):1880-1890.Shah PK, Sharifi B. Insights into the molecular mechanisms of plaque rupture and thrombosis. Biochemistry of Atherosclerosis. New York: Springer; 2006. Р. 455-563.Shah PK, Sharifi B. Insights into the molecular mechanisms of plaque rupture and thrombosis. Biochemistry of Atherosclerosis. New York: Springer; 2006. Р. 455-563.Titov VN. Obshchnost' ateroskleroza i vospaleniya: spetsifichnost' ateroskleroza kak vospalitel'nogo protsessa. Rossiyskiy kardiologicheskiy zhurnal. 1999;(5): 48-56.Titov VN. Obshchnost' ateroskleroza i vospaleniya: spetsifichnost' ateroskleroza kak vospalitel'nogo protsessa. Rossiyskiy kardiologicheskiy zhurnal. 1999;(5): 48-56.Barbarash LS, Kashtalap VV, Zykov MV, Usol'tseva EN, Iakubik GG, Karetnikova VN, Kudryavtseva IA, Barbarash OL. Prevalence and clinical value of multifocal atherosclerosis in patients with myocardial infarction and ST segment elevation. Cardiology & cardiovascular surgery. 2010;(5): 31-36. [Russian]Barbarash LS, Kashtalap VV, Zykov MV, Usol'tseva EN, Iakubik GG, Karetnikova VN, Kudryavtseva IA, Barbarash OL. Prevalence and clinical value of multifocal atherosclerosis in patients with myocardial infarction and ST segment elevation. Cardiology & cardiovascular surgery. 2010;(5): 31-36. [Russian]Roitman EV, Azizova OA, Aseichev AV, Morozov YA. Effect of oxidized fibrinogens on blood coagulation. Bulletin of Experimental Biology and Medicine. 2004;(9): 277-279.Roitman EV, Azizova OA, Aseichev AV, Morozov YA. Effect of oxidized fibrinogens on blood coagulation. Bulletin of Experimental Biology and Medicine. 2004;(9): 277-279.Szodoray P, Timar O, Veres K, Der H, Szomjak E, Lakos G, Aleksza M, Nakken B, Szegedi G, Soltesz P. TH1/TH2 imbalance, measured by circulating and intracytoplasmic inflammatory cytokines-immunological alterations in acute coronary syndrome and stable coronary artery disease. Scand J Immunol. 2006 Sep;64(3):336-344.Szodoray P, Timar O, Veres K, Der H, Szomjak E, Lakos G, Aleksza M, Nakken B, Szegedi G, Soltesz P. TH1/TH2 imbalance, measured by circulating and intracytoplasmic inflammatory cytokines-immunological alterations in acute coronary syndrome and stable coronary artery disease. Scand J Immunol. 2006 Sep;64(3):336-344.Bode JG, Fischer R, Häussinger D, Graeve L, Heinrich PC, Schaper F. The inhibitory effect of IL-1 beta on IL-6-induced alpha 2-macroglobulin expression is due to activation of NF-kappa B. J Immunol. 2001 Aug 1;167(3):1469-1481.Bode JG, Fischer R, Häussinger D, Graeve L, Heinrich PC, Schaper F. The inhibitory effect of IL-1 beta on IL-6-induced alpha 2-macroglobulin expression is due to activation of NF-kappa B. J Immunol. 2001 Aug 1;167(3):1469-1481.
The authors declare that there are no conflicts of interest present.