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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/2072-0351-5421</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-5421</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Принципы терапии впервые выявленного сахарного диабета 2 типа. Место Амарила (глимепирида): свойства, эффективность, безопасность</article-title><trans-title-group xml:lang="en"><trans-title>Type 2 diabetes therapy at the time of diagnosis. Glimepiride: property, efficiency, safety</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смирнова</surname><given-names>Ольга Михайловна</given-names></name><name name-style="western" xml:lang="en"><surname>Smirnova</surname><given-names>Olga Mikhailovna</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГУ Эндокринологический научный центр Росмедтехнологий, Москва</institution></aff><aff xml:lang="en"><institution>Endocrinology Research Centre, Moscow</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>15</day><month>03</month><year>2009</year></pub-date><volume>12</volume><issue>1</issue><issue-title>№1 (2009)</issue-title><fpage>43</fpage><lpage>47</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Смирнова О.М., 2009</copyright-statement><copyright-year>2009</copyright-year><copyright-holder xml:lang="ru">Смирнова О.М.</copyright-holder><copyright-holder xml:lang="en">Smirnova O.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/5421">https://www.dia-endojournals.ru/jour/article/view/5421</self-uri><abstract><p>В клинической практике имеется эффективный сахароснижающий препарат Амарил, обеспечивающий хороший контроль гликемии при однократном приеме, способствующий снижению массы тела, не имеющий побочных действий, обладающий экстрапанкреатическим инсулинсберегающим действием, безопасный при назначении лицам с сердечно-сосудистыми заболеваниями с большим диапазоном дозировок. Наличие инсулинсберегающего эффекта отличает Амарил от других производных сульфонилмочевины, поскольку именно это предохраняет пул бета-клеток от апоптоза и способствует более продолжительному сохранению их секреторной функции. Данный препарат может быть препаратом выбора при медикаментозной терапии впервые выявленного СД2.</p></abstract><kwd-group xml:lang="ru"><kwd>сахарный диабет 2 типа</kwd><kwd>производные сульфонилмочевины</kwd><kwd>селективность</kwd><kwd>рецепторы сульфонилмочевины</kwd><kwd>алгоритмы лечения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>type 2 diabetes mellitus</kwd><kwd>sulfonylurea derivatives</kwd><kwd>selectivity</kwd><kwd>sulfonylurea receptors</kwd><kwd>treatment algorithm</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Алгоритмы специализированногй медицинской помощи больным сахарным диабетом. Под ред. И.И. Дедова, М.В. 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