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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/2072-0351-5389</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-5389</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Цели и задачи исследования ADVANCE. Дизайн исследования. Обоснование применения диабетона МВ</article-title><trans-title-group xml:lang="en"><trans-title>Tasks and objectives of the ADVANCE study. Design of the study. Rationale for the use of diabeton MB</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смирнова</surname><given-names>Ольга Михайловна</given-names></name><name name-style="western" xml:lang="en"><surname>Smirnova</surname><given-names>Olga Mikhailovna</given-names></name></name-alternatives><email xlink:type="simple">dr_smr@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГУ Эндокринологический научный центр Росмедтехнологий, Москва</institution></aff><aff xml:lang="en"><institution>Endocrinology Research Centre, Moscow</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>15</day><month>06</month><year>2009</year></pub-date><volume>12</volume><issue>2</issue><issue-title>№2 (2009)</issue-title><fpage>6</fpage><lpage>9</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Смирнова О.М., 2009</copyright-statement><copyright-year>2009</copyright-year><copyright-holder xml:lang="ru">Смирнова О.М.</copyright-holder><copyright-holder xml:lang="en">Smirnova O.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/5389">https://www.dia-endojournals.ru/jour/article/view/5389</self-uri><abstract><p>Результаты исследования ADVANCE, безусловно, будут иметь огромное значение для реальной клинической практики, поскольку результаты подобных исследований помогают разработать эффективную систему профилактики сахарного диабета и, следовательно, уменьшить последствия грядущего резкого роста распространенности этого заболевания.</p></abstract><kwd-group xml:lang="ru"><kwd>сахарный диабет</kwd><kwd>факторы риска</kwd><kwd>микро- и макрососудистые осложнения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>diabetes mellitus</kwd><kwd>risk factors</kwd><kwd>micro- and microvascular complications</kwd><kwd>arterial hypertension</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Guillasseau PJ, Greb W. 24-hour glycemic profile in type 2 diabetic patients treated with gliclazide modified realease once daily. 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