<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/2072-0351-5369</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-5369</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Молекулярная генетика сахарного диабета у детей и подростков (по материалам 32-33 конгрессов Международного общества по изучению сахарного диабета у детей и подростков (ISPAD)</article-title><trans-title-group xml:lang="en"><trans-title>Molekulyarnaya genetika sakharnogo diabeta u detey i podrostkov (po materialam 32-33 kongressov Mezhdunarodnogo obshchestva po izucheniyu sakharnogo diabeta u detey i podrostkov (ISPAD)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Меликян</surname><given-names>М А</given-names></name><name name-style="western" xml:lang="en"><surname>Melikyan</surname><given-names>M A</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кураева</surname><given-names>Тамара Леонидовна</given-names></name><name name-style="western" xml:lang="en"><surname>Kuraeva</surname><given-names>Tamara Leonidovna</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дубинина</surname><given-names>И А</given-names></name><name name-style="western" xml:lang="en"><surname>Dubinina</surname><given-names>I A</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГУ Эндокринологический научный центр Росмедтехнологий, Москва</institution></aff><aff xml:lang="en"><institution>Endocrinology Research Centre, Moscow</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>15</day><month>09</month><year>2008</year></pub-date><volume>11</volume><issue>3</issue><issue-title>№3 (2008)</issue-title><fpage>78</fpage><lpage>80</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Меликян М.А., Кураева Т.Л., Дубинина И.А., 2008</copyright-statement><copyright-year>2008</copyright-year><copyright-holder xml:lang="ru">Меликян М.А., Кураева Т.Л., Дубинина И.А.</copyright-holder><copyright-holder xml:lang="en">Melikyan M.A., Kuraeva T.L., Dubinina I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/5369">https://www.dia-endojournals.ru/jour/article/view/5369</self-uri><abstract><p>Работы, представленные на конгрессах, наглядно демонстрируют существенный прогресс в изучении генетических аспектов сахарного диабета. Как справедливо заметил Т.Г. Барретт, еще 15 лет назад сахарный диабет у детей было принято считать диабетом 1 типа, и при наличии осмотических симптомов у ребенка необходимость в дифференциальной диагностике отпадала. Со временем диабет, ассоциированный с внепанкратическими проявлениями, стал характеризоваться как синдром. Были выявлены генетические нарушения, стали возможными диагностические тесты и появилось специфическое лечение?. </p></abstract><kwd-group xml:lang="ru"><kwd>молекулярная генетика</kwd><kwd>сахарный диабет</kwd><kwd>конгресс</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Barrett T. G. Genetic syndromes and diabetes mellitus. Pediatric Diabetes 2006-vol. 7, S3.</mixed-citation><mixed-citation xml:lang="en">Barrett T. G. Genetic syndromes and diabetes mellitus. Pediatric Diabetes 2006-vol. 7, S3.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Carlsson A., Blom L., Forsander G., Ivarsson S-A., Karlsson A-K., Kernell A., Lernmark A., Lindblad B., Ludvigsson J., Marcus C., Nilsson A., Rastkhani H., Zachrisson I. Better Diabetes Diagnosis (BDD): A countrywide registry of incident patients suggests an altered HLA genotype distribution from 1986-87. Pediatric Diabetes 2006-vol. 7, P27.</mixed-citation><mixed-citation xml:lang="en">Carlsson A., Blom L., Forsander G., Ivarsson S-A., Karlsson A-K., Kernell A., Lernmark A., Lindblad B., Ludvigsson J., Marcus C., Nilsson A., Rastkhani H., Zachrisson I. Better Diabetes Diagnosis (BDD): A countrywide registry of incident patients suggests an altered HLA genotype distribution from 1986-87. Pediatric Diabetes 2006-vol. 7, P27.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Galli-Tsinopoulou, Trouva, Klados, Marinou, Sapountzis, Lazidou, Fleva, Daniilidis, Kokaraki, Stylianou, Nousia-Arvanitakis. HLA alleles in children and adolescents with type 1 diabetes mellitus in northern Greece. Pediatric Diabetes 2006-vol. 7, R17.</mixed-citation><mixed-citation xml:lang="en">Galli-Tsinopoulou, Trouva, Klados, Marinou, Sapountzis, Lazidou, Fleva, Daniilidis, Kokaraki, Stylianou, Nousia-Arvanitakis. HLA alleles in children and adolescents with type 1 diabetes mellitus in northern Greece. Pediatric Diabetes 2006-vol. 7, R17.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kantor I. Clinical characteristics of our patient suffering from BETA2/NeuroD1 genetic malformation. Pediatric Diabetes 2006-vol. 7, R19.</mixed-citation><mixed-citation xml:lang="en">Kantor I. Clinical characteristics of our patient suffering from BETA2/NeuroD1 genetic malformation. Pediatric Diabetes 2006-vol. 7, R19.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Mihu M., Mihai C. M., Toringhibel M. Kearns-Sayre Syndrome (KSS). Diagnostic delay in one case. Pediatric Diabetes 2006-vol. 7, R15.</mixed-citation><mixed-citation xml:lang="en">Mihu M., Mihai C. M., Toringhibel M. Kearns-Sayre Syndrome (KSS). Diagnostic delay in one case. Pediatric Diabetes 2006-vol. 7, R15.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Paskova M. Sulfonylurea instead of insulin in PNDM patients with activating mutation in the gene KCNJ11 encoding the Kir6.2 subunit led to significant improvement of DM compensation. Pediatric Diabetes 2006-vol. 7, P34.</mixed-citation><mixed-citation xml:lang="en">Paskova M. Sulfonylurea instead of insulin in PNDM patients with activating mutation in the gene KCNJ11 encoding the Kir6.2 subunit led to significant improvement of DM compensation. Pediatric Diabetes 2006-vol. 7, P34.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Peretz A., Israel S., Herschkovitz E., Loewenthal N., Abu-Rabiah Y., Chechik T., Birk O., Leiberman E. Genetic and immunologic basis of diabetes in an extended consanguineous Bedouin family. Pediatric Diabetes 2006-vol. 7, P29.</mixed-citation><mixed-citation xml:lang="en">Peretz A., Israel S., Herschkovitz E., Loewenthal N., Abu-Rabiah Y., Chechik T., Birk O., Leiberman E. Genetic and immunologic basis of diabetes in an extended consanguineous Bedouin family. Pediatric Diabetes 2006-vol. 7, P29.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Rami B., Bodamer O., Item B., Heitger A., Haas O., Huber W. D., Schober E. Clinical and molecular findings in an atypical case of IPEXSyndrome. Pediatric Diabetes 2006-vol. 7, P28.</mixed-citation><mixed-citation xml:lang="en">Rami B., Bodamer O., Item B., Heitger A., Haas O., Huber W. D., Schober E. Clinical and molecular findings in an atypical case of IPEXSyndrome. Pediatric Diabetes 2006-vol. 7, P28.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Skorka A., Pankowska E., Szypowska A., Choim M., Kostrzewa G., Szalecki M., Korniszewski L., Pioski R. Analysis of genetic factors predisposing to type 1 diabetes in children under 5 years of age. Pediatric Diabetes 2006-vol. 7, P25.</mixed-citation><mixed-citation xml:lang="en">Skorka A., Pankowska E., Szypowska A., Choim M., Kostrzewa G., Szalecki M., Korniszewski L., Pioski R. Analysis of genetic factors predisposing to type 1 diabetes in children under 5 years of age. Pediatric Diabetes 2006-vol. 7, P25.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Slingerland A. S., Nubour R., Hadders-Algra M., Hattersley A. T., Bruining G. J. Kir6.2 impact of mutation and treatment on diabetes and neurology. Pediatric Diabetes 2006-vol. 7, P30.</mixed-citation><mixed-citation xml:lang="en">Slingerland A. S., Nubour R., Hadders-Algra M., Hattersley A. T., Bruining G. J. Kir6.2 impact of mutation and treatment on diabetes and neurology. Pediatric Diabetes 2006-vol. 7, P30.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Datz. N., Nestoris C., Danne T., Driesel A.J. Clinical parameters for molecular testing of maturity onset diabetes in the young (MODY). Pediatric Diabetes 2007-vol. 8, P/WED/52.</mixed-citation><mixed-citation xml:lang="en">Datz. N., Nestoris C., Danne T., Driesel A.J. Clinical parameters for molecular testing of maturity onset diabetes in the young (MODY). Pediatric Diabetes 2007-vol. 8, P/WED/52.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Jesic M., Sajic S., Zdravkovic V., Maringa M. Maturity onset diabetes of the young type 3: a case report of a female child responsive to a low dose of sulfonylurea. Pediatric Diabetes 2007-vol. 8, P/WED/53</mixed-citation><mixed-citation xml:lang="en">Jesic M., Sajic S., Zdravkovic V., Maringa M. Maturity onset diabetes of the young type 3: a case report of a female child responsive to a low dose of sulfonylurea. Pediatric Diabetes 2007-vol. 8, P/WED/53</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Hofer S., Flanagan S., Ellard S., Steichen E. Family report on two siblings affected by transient neonatal diabetes -a novel SUR 1 mutation inherited from the father. Pediatric Diabetes 2007-vol. 8, P/WED/58.</mixed-citation><mixed-citation xml:lang="en">Hofer S., Flanagan S., Ellard S., Steichen E. Family report on two siblings affected by transient neonatal diabetes -a novel SUR 1 mutation inherited from the father. Pediatric Diabetes 2007-vol. 8, P/WED/58.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Lombardo F., Salzano G., Bruno L., Calabro M. P., F. De Luca. Cardiovascular involvement in Wolfram syndrome. Pediatric Diabetes 2007-vol. 8, P/WED/50.</mixed-citation><mixed-citation xml:lang="en">Lombardo F., Salzano G., Bruno L., Calabro M. P., F. De Luca. Cardiovascular involvement in Wolfram syndrome. Pediatric Diabetes 2007-vol. 8, P/WED/50.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Nakavachara P., Pattaragarn A., Likitmaskul S. A boy with Wolfram syndrome presenting with diabetes mellitus and marked polyuria, bilateral hydronephrosis and hydroureter mimicking obstructive uropathy. Pediatric Diabetes 2007-vol. 8, P/WED/51.</mixed-citation><mixed-citation xml:lang="en">Nakavachara P., Pattaragarn A., Likitmaskul S. A boy with Wolfram syndrome presenting with diabetes mellitus and marked polyuria, bilateral hydronephrosis and hydroureter mimicking obstructive uropathy. Pediatric Diabetes 2007-vol. 8, P/WED/51.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Micle I., Marazan M., Marginean O., Pop E., Giurescu R. Permanent neonatal diabetes mellitus - sulphonylureas treatment. Pediatric Diabetes 2007-vol. 8, P/WED/55.</mixed-citation><mixed-citation xml:lang="en">Micle I., Marazan M., Marginean O., Pop E., Giurescu R. Permanent neonatal diabetes mellitus - sulphonylureas treatment. Pediatric Diabetes 2007-vol. 8, P/WED/55.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
