diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM2013411-16diaendo-3847Research ArticleГенетикаGeneticsГенетические основы сахарного диабета 2 типаGenetic framework of type 2 diabetes mellitusБондарьИрина АркадьевнаBondar'Irina Arkad'evna

MD, PhD, Professor, Head of Endocrinology Department

bondaria@oblmed.nsk.ruШабельниковаОлеся ЮрьевнаShabel'nikovaOlesya Yur'evna

MD, PhD, Head of Regional Diabetic Center

odc@oblmed.nsk.ruГБОУ ВПО Новосибирский государственный медицинский университет, НовосибирскРоссияNovosibirsk State Medical University, NovosibirskRussian FederationГБУЗ НСО Новосибирская областная клиническая больница, НовосибирскРоссияNovosibirsk State Regional Hospital, NovosibirskRussian Federation2013181220131641116Copyright © Бондарь И.А., Шабельникова О.Ю., 20132013Бондарь И.А., Шабельникова О.Ю.Bondar' I.A., Shabel'nikova O.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/3847

В настоящее время описано более 100 генов, ассоциированных с риском развития сахарного диабета 2 типа (СД2). В обзоре приведены гены, связанные с развитием СД2, продукты, которые влияют на секрецию инсулина, адипогенез, инсулинорезистентность, однако для большинства генов точные молекулярные механизмы участия в патогенезе СД2 окончательно не установлены.

More than 100 genes associated with the risk of type 2 diabetes mellitus (T2DM) are now established. Most of them affect insulin secretion, adipogenesis and insulin resistance, but the exact molecular mechanisms determining their involvement in the pathogenesis of T2DM are not understood completely.

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The authors declare that there are no conflicts of interest present.