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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/DM2013417-22</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-3846</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Генетика</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Genetics</subject></subj-group></article-categories><title-group><article-title>Ассоциация полиморфных маркеров rs7903146 гена TCF7L2 и rs1801282 гена PPARG (Pro12Ala) с сахарным диабетом 2 типа в Новосибирской области</article-title><trans-title-group xml:lang="en"><trans-title>Rs7903146 variant of TCF7L2 gene and rs18012824 variant of PPARG2 gene (Pro12Ala) are associated with type 2 diabetes mellitus in Novosibirsk population</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бондарь</surname><given-names>Ирина Аркадьевна</given-names></name><name name-style="western" xml:lang="en"><surname>Bondar'</surname><given-names>Irina Arkad'evna</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>MD, PhD, Professor, Head of Endocrinology Department</p></bio><email xlink:type="simple">bondaria@oblmed.nsk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филипенко</surname><given-names>Максим Леонидович</given-names></name><name name-style="western" xml:lang="en"><surname>Filipenko</surname><given-names>Maksim Leonidovich</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>PhD, Head of Farmacogenomics Laboratory</p></bio><email xlink:type="simple">max@niboch.nsc.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шабельникова</surname><given-names>Олеся Юрьевна</given-names></name><name name-style="western" xml:lang="en"><surname>Shabel'nikova</surname><given-names>Olesya Yur'evna</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, руководитель областного диабетологического центра</p></bio><bio xml:lang="en"><p>MD, PhD, Head of Regional Diabetic Center</p></bio><email xlink:type="simple">odc@oblmed.nsk.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соколова</surname><given-names>Екатерина Александровна</given-names></name><name name-style="western" xml:lang="en"><surname>Sokolova</surname><given-names>Ekaterina Alexandrovna</given-names></name></name-alternatives><bio xml:lang="ru"><p>инженер лабораторнии фармакогеномики</p></bio><bio xml:lang="en"><p>Researcher in Farmacogenomics Laboratory</p></bio><email xlink:type="simple">max@niboch.nsc.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО Новосибирский Государственный медицинский университет, Новосибирск</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University, Novosibirsk</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУН Институт химической биологии и фундаментальной медицины, Новосибирск</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Chemical Biology and Fundamental Medicine, Novosibirsk</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГБУЗ НСО Новосибирская областная клиническая больница, Новосибирск</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Regional Hospital, Novosibirsk</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>18</day><month>12</month><year>2013</year></pub-date><volume>16</volume><issue>4</issue><fpage>17</fpage><lpage>22</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бондарь И.А., Филипенко М.Л., Шабельникова О.Ю., Соколова Е.А., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Бондарь И.А., Филипенко М.Л., Шабельникова О.Ю., Соколова Е.А.</copyright-holder><copyright-holder xml:lang="en">Bondar' I.A., Filipenko M.L., Shabel'nikova O.Y., Sokolova E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/3846">https://www.dia-endojournals.ru/jour/article/view/3846</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>сахарный диабет 2 типа</kwd><kwd>генетика</kwd><kwd>дисфункция бета-клеток: инсулинорезистентность</kwd><kwd>PPARG</kwd><kwd>TCF7L2</kwd></kwd-group><kwd-group xml:lang="en"><kwd>type 2 diabetes mellitus</kwd><kwd>genetics</kwd><kwd>beta-cell dysfunction</kwd><kwd>insulin resistance</kwd><kwd>PPARG2</kwd><kwd>TCF7L2</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Российский Фонд Фундаментальных Исследований (РФФИ), грант № 13-04-00520</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Robertson RP. 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