diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/2072-0351-3753diaendo-3753Research ArticleСтатьиArticlesРоль препаратов сульфонилмочевины в развитии сердечно-сосудистых осложнений при сахарном диабете 2 типаSulfonylureas and cardiovascular complications of type 2 diabetes mellitusНедосуговаЛюдмила ВикторовнаNedosugovaLyudmila Viktorovna

д.м.н., проф. кафедры эндокринологии факультета послевузовского профессионального образования врачей

d.m.n., prof. kafedry endokrinologii fakul'teta poslevuzovskogo professional'nogo obrazovaniya vrachey

profmila@rambler.ruГБОУ ВПО Первый Московский государственный медицинский университет им. И.М. Сеченова, МоскваI.M. Sechenov First Moscow State Medical University, Moscow201315062013162№2 (2013)2635Copyright © Недосугова Л.В., 20132013Недосугова Л.В.Nedosugova L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/3753

Статья посвящена обсуждению возможных механизмов развития сердечно-сосудистых осложнений (ССО) при лечении пациентов с сахарным диабетом 2 типа препаратами сульфонилмочевины (ПСМ). Обсуждаются молекулярные аспекты панкреатического и экстрапанкреатического действия препаратов этой группы, оценивается различная активность от- дельных ПСМ в отношении рисков развития гипогликемических состояний как предикторов острых ССО, а также возмож- ность негативного влияния на феномен ишемического прекондиционирования и механизмы антиаритмического эффекта некоторых ПСМ. На основе анализа современных литературных данных обосновывается эффективность и безопасность Амарила в отношении кардиоваскулярных рисков у больных сахарным диабетом 2 типа, страдающих ИБС.

This article addresses possible mechanisms for development of cardiovascular events (CVE) in type 2 diabetes mellitus (T2DM) patients treated with sulfonylurea derivatives (SU). Several problems are highlighted in this review, including molecular aspects of pancreatic and extrapancreatic action of these drugs, their comparative potential to induce hypoglycemic events (as predictors of acute CVE) and impairment of ischemic preconditioning, as well as antiarrhythmic activity of certain SU agents. Finally, efficacy and cardiovascular safety of glimepiride in T2DM patients is substantiated based on a survey of current literature.

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The authors declare that there are no conflicts of interest present.