diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/2072-0351-3751diaendo-3751Research ArticleСтатьиArticlesМелатонин при сахарном диабете: от патофизиологии к перспективам леченияMelatonin and diabetes: from pathophysiology to the treatment perspectivesКоненковВладимир ИосифовичKonenkovVladimir Iosifovich

академик РАМН, д.м.н., проф., директор

akademik RAMN, d.m.n., prof., direktor

-КлимонтовВадим ВалерьевичKlimontovVadim Valerievich

д.м.н., зав. лабораторией эндокринологии

d.m.n., zav. laboratoriey endokrinologii

klimontov@mail.ruМичуринаСветлана ВикторовнаMichurinaSvetlana Viktorovna

д.м.н., профессор, г.н.с. лаборатории функциональной морфологии лимфатической системы

d.m.n., professor, g.n.s. laboratorii funktsional'noy morfologii limfaticheskoy sistemy

-ПрудниковаМарина АлексеевнаPrudnikovaM A

м.н.с. лаборатории эндокринологии

m.n.s. laboratorii endokrinologii

-ИщенкоИрина ЮрьевнаIshenkoI Ju

к.б.н., с.н.с. лаборатории функциональной морфологии лимфатической системы

k.b.n., s.n.s. laboratorii funktsional'noy morfologii limfaticheskoy sistemy

-ФГБУ НИИ клинической и экспериментальной лимфологии, НовосибирскResearch Institute of Clinical and Experimental Lymphology, Novosibirsk201315062013162№2 (2013)1116Copyright © Коненков В.И., Климонтов В.В., Мичурина С.В., Прудникова М.А., Ищенко И.Ю., 20132013Коненков В.И., Климонтов В.В., Мичурина С.В., Прудникова М.А., Ищенко И.Ю.Konenkov V.I., Klimontov V.V., Michurina S.V., Prudnikova M.A., Ishenko I.J.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/3751

Гормон эпифиза мелатонин обеспечивает синхронизацию секреции инсулина и гомеостаза глюкозы с чередованием светлого и темного времени суток. Нарушение альянса между опосредованными мелатонином циркадными ритмами и секрецией инсулина наблюдается при сахарном диабете (СД) 1 и 2 типа (СД1 и СД2). Дефицит инсулина при СД1 сопровождается повышением продукции мелатонина в эпифизе. СД2, напротив, характеризуется снижением секреции мелатонина. В пол- ногеномных исследованиях варианты гена рецептора мелатонина MT2 (rs1387153 и rs10830963) ассоциированы с уровнем гликемии натощак, функцией бета-клеток и СД2. Мелатонин увеличивает пролиферацию и неогенез бета-клеток, улучшает чувствительность к инсулину и уменьшает окислительный стресс в сетчатке и почках в экспериментальных моделях СД. Для оценки терапевтической ценности данного гормона у больных СД необходимы дальнейшие исследования.

Pineal hormone melatonin synchronizes insulin secretion and glucose homeostasis with solar periods. Misalliance between melatonin-mediated circadian rhythms and insulin secretion characterizes diabetes mellitus type 1 (T1DM) and type 2 (T2DM). Insulin deficiency in T1DM is accompanied by increased melatonin production. Conversely, T2DM is characterized by diminished melatonin secretion. In genome-wide association studies the variants of melatonin receptor MT2 gene (rs1387153 and rs10830963) were associated with fasting glucose, beta-cell function and T2DM. In experimental models of diabetes melatonin enhanced beta-cell proliferation and neogenesis, improved insulin resistance and alleviated oxidative stress in retina and kidneys. However, further investigation is required to assess the therapeutic value of melatonin in diabetic patients.

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The authors declare that there are no conflicts of interest present.