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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/2072-0351-3603</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-3603</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Сахарный диабет 2 типа: время изменить концепцию</article-title><trans-title-group xml:lang="en"><trans-title>Type 2 diabetes mellitus: time to change the concept</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Левит</surname><given-names>Шмюэль</given-names></name><name name-style="western" xml:lang="en"><surname>Levit</surname><given-names>Shmuel</given-names></name></name-alternatives><email xlink:type="simple">shlevit@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филиппов</surname><given-names>Юрий Иванович</given-names></name><name name-style="western" xml:lang="en"><surname>Filippov</surname><given-names>Yury Ivanovich</given-names></name></name-alternatives><email xlink:type="simple">yuriyivanovich@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горелышев</surname><given-names>Александр Сергеевич</given-names></name><name name-style="western" xml:lang="en"><surname>Gorelyshev</surname><given-names>A S</given-names></name></name-alternatives><email xlink:type="simple">sathandi@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт эндокринологии и метаболизма, Медицинский центр Шеба, Тель-Авив</institution></aff><aff xml:lang="en"><institution>Institute of Endocrinology and Metabolism, Sheba medical center, Tel-Aviv</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ Эндокринологический научный центр, Москва</institution></aff><aff xml:lang="en"><institution>Endocrinology Research Centre, Moscow</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>15</day><month>03</month><year>2013</year></pub-date><volume>16</volume><issue>1</issue><issue-title>№1 (2013)</issue-title><fpage>91</fpage><lpage>102</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Левит Ш., Филиппов Ю.И., Горелышев А.С., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Левит Ш., Филиппов Ю.И., Горелышев А.С.</copyright-holder><copyright-holder xml:lang="en">Levit S., Filippov Y.I., Gorelyshev A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/3603">https://www.dia-endojournals.ru/jour/article/view/3603</self-uri><abstract><p>Сахарный диабет ? гетерогенная группа заболеваний, объединяемая многими характерными чертами, но, очевидно, тре- бующая различных терапевтических подходов к лечению. В настоящем обзоре обсуждаются ключевые патогенетические особенности сахарного диабета 2 типа, обусловливающие выбор целей лечения и определяющие формирование оптимальной терапевтической тактики. Сформулирована и патогенетически обоснована новая гравицентрическая? концепция лечения сахарного диабета 2 типа, во многом отличающаяся от принятого в настоящее время подхода.</p></abstract><trans-abstract xml:lang="en"><p>Diabetes mellitus is a heterogeneous group of diseases that, although unified by a number of characteristics, require a differential thera- peutic approach. Current review discusses key pathogenic features of type 2 diabetes mellitus that determine therapy goals and options in management. We further enunciate and pathogenetically substantiate a new "gravicentric" concept for treatment of type 2 diabetes mellitus that differs in many ways from the common contemporary approach.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сахарный диабет 2 типа</kwd><kwd>масса тела</kwd><kwd>ожирение</kwd><kwd>инсулин</kwd><kwd>инкретины</kwd><kwd>бариатрическая хирургия</kwd><kwd>сердечно- сосудистая смертность</kwd><kwd>ремиссия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>type 2 diabetes mellitus</kwd><kwd>body mass</kwd><kwd>obesity</kwd><kwd>insulin</kwd><kwd>incretins</kwd><kwd>bariatric surgery</kwd><kwd>cardiovascular mortality</kwd><kwd>remission</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">IDF Diabetes Atlas, Fifth Edition. 2011.</mixed-citation><mixed-citation xml:lang="en">IDF Diabetes Atlas, Fifth Edition. 2011.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Action to Control Cardiovascular Risk in Diabetes Study Group, Gerstein HC, Miller ME, Byington RP, Goff DC, Jr., Bigger JT, Buse JB, Cushman WC, Genuth S, Ismail-Beigi F, Grimm RH Jr, Probstfield JL, Simons-Morton DG, Friedewald WT. 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