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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/DM13281</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-13281</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Хроническая болезнь почек при сахарном диабете 2 типа: тренды в распространенности, клинические фенотипы, исходы</article-title><trans-title-group xml:lang="en"><trans-title>Chronic kidney disease in type 2 diabetes: trends in prevalence, clinical phenotypes and outcomes</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3502-5892</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корбут</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Korbut</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Корбут Антон Иванович - к.м.н.</p><p>Новосибирск</p><p>Researcher ID R-7923-2017; Scopus Author ID 57151138800</p></bio><bio xml:lang="en"><p>Anton I. Korbut - MD, PhD.</p><p>Novosibirsk</p><p>Researcher ID R-7923-2017; Scopus Author ID 57151138800</p></bio><email xlink:type="simple">korbutai@icgbio.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5407-8722</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Климонтов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Klimontov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Климонтов Вадим Валерьевич - д.м.н., профессор РАН.</p><p>630060, Новосибирск, ул. Тимакова, д. 2</p><p>ResearcherID R-7689-2017; Scopus Author ID 8295977000</p></bio><bio xml:lang="en"><p>Vadim V. Klimontov - MD, PhD, Professor.</p><p>2 Timakov street, Novosibirsk 630060</p><p>ResearcherID R-7689-2017; Scopus Author ID 8295977000</p></bio><email xlink:type="simple">klimontov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт клинической и экспериментальной лимфологии — филиал Федерального государственного бюджетного научного учреждения «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук» (НИИКЭЛ — филиал ИЦиГ СО РАН)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Clinical and Experimental Lymрhology – Branch of the Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences (RICEL - Branch of IC&amp;G SB RAS)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>24</day><month>07</month><year>2025</year></pub-date><volume>28</volume><issue>3</issue><fpage>265</fpage><lpage>273</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Корбут А.И., Климонтов В.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Корбут А.И., Климонтов В.В.</copyright-holder><copyright-holder xml:lang="en">Korbut A.I., Klimontov V.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/13281">https://www.dia-endojournals.ru/jour/article/view/13281</self-uri><abstract><p>Сахарный диабет 2 типа (СД2) является одной из ведущих причин хронической болезни почек (ХБП). В данном обзоре проанализированы результаты исследований, оценивавших распространенность, клинические фенотипы и исходы ХБП при СД2. В последние 20–30 лет наблюдается глобальный тренд на увеличение числа больных СД2 и ХБП. При этом распространенность ХБП среди больных СД2, по-видимому, остается стабильной и составляет в среднем 25–30%. Исследования из разных стран демонстрируют как восходящие, так и нисходящие тренды в распространенности ХБП среди пациентов с СД2. Это может объясняться отличиями в дизайне исследований и полноте скрининга ХБП, а также истинными различиями в распространенности ХБП в разных популяциях. У больных CД2 ХБП гетерогенна по морфологическим и клиническим характеристикам, течению и исходам. Очевидным трендом в эпидемиологии ХБП у больных СД2 является увеличение распространенности снижения почечной функции при отсутствии альбуминурии. Женский пол, пожилой возраст, оптимальный контроль гликемии и артериальной гипертензии, применение блокаторов ренин-ангиотезиновой системы и отсутствие диабетической ретинопатии ассоциированы с неальбуминурической ХБП при СД2. Больные СД2 с альбуминурическим фенотипом ХБП, по-видимому, имеют больший риск развития терминальной ХБП и основных неблагоприятных сердечно-сосудистых событий в сравнении с пациентами с СД2 и неальбуминурической ХБП. Репортируемая заболеваемость терминальной почечной недостаточностью у больных СД2 варьирует в широких пределах, от 0,41 до 6,9 случая на 1000 пациенто-лет. Разнообразие данных может объясняться различиями исходных характеристик больных и разной длительностью наблюдения. Гетерогенность дизайна проведенных к настоящему времени исследований, небольшое число проспективных исследований на больших выборках затрудняют объективную оценку динамики распространенности и заболеваемости ХБП у больных СД2. Крайне необходимы исследования эпидемиологии ХБП у больных СД2 в реальной клинической практике.</p></abstract><trans-abstract xml:lang="en"><p>Type 2 diabetes (T2D) is a leading cause of chronic kidney disease (CKD). This review analyzes the results of studies assessing the prevalence, clinical phenotypes, and outcomes of CKD in T2D. Over the past 20–30 years, there has been a global trend toward an increase in the number of patients with T2D and CKD. At the same time, the prevalence of CKD among patients with T2D appears to remain stable and averages 25–30%. Studies from different countries demonstrate both upward and downward trends in the prevalence of CKD among patients with T2D. This can be explained by differences in study design, CKD screening quality, and real differences in the prevalence of CKD in different populations. In patients with T2D, CKD is heterogeneous in morphological and clinical characteristics, course, and outcomes. An obvious current trend in the epidemiology of CKD in patients with T2D is an increasing prevalence of renal function decline in the absence of albuminuria. Female sex, older age, optimal glycemic and hypertension control, use of renin-angiotensin system blockers, and the absence of diabetic retinopathy are associated with non-albuminuric CKD in T2D. Patients with T2D with the albuminuric phenotype of CKD appear to have a higher risk of developing end-stage renal disease and major adverse cardiovascular events compared with patients with T2D and non-albuminuric CKD. The reported incidence of end-stage renal disease in patients with T2D varies widely, from 0.41 to 6.9 cases per 1000 patient-years. The diversity of data may be explained by differences in baseline patient characteristics and different durations of follow-up. The heterogeneity of the design of studies conducted to date, the small number of prospective studies on large patient samples make it difficult to objectively assess the dynamics of CKD prevalence and incidence in patients with T2D. Further real-world evidence studies are urgently needed to assess the epidemiology of CKD in patients with T2D.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сахарный диабет 2 типа</kwd><kwd>хроническая болезнь почек</kwd><kwd>терминальная почечная недостаточность</kwd><kwd>скорость клубочковой фильтрации</kwd><kwd>альбуминурия</kwd><kwd>распространенность</kwd><kwd>заболеваемость</kwd></kwd-group><kwd-group xml:lang="en"><kwd>type 2 diabetes</kwd><kwd>chronic kidney disease</kwd><kwd>end-stage renal disease</kwd><kwd>glomerular filtration rate</kwd><kwd>albuminuria</kwd><kwd>prevalence</kwd><kwd>incidence</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено за счет средств государственного задания НИИКЭЛ — филиал ИЦиГ СО РАН.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">GBD Chronic Kidney Disease Collaboration. 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